Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Lipid-signaling in regulation of pancreatic islet development: novel function od stearoyl-CoA desaturase and monoacylglycerol lipase

2013/10/E/NZ3/00670

Keywords:

pancreas organogenesis lipid mediators stearoyl-CoA desaturase monoacylglycerol lipase insulin glucagon

Descriptors:

  • NZ3_2: Cell physiology
  • NZ3_13: Developmental biology in animals

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Instytut Biologii Doświadczalnej im. M. Nenckiego PAN

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Agnieszka Dobrzyń 

Number of co-investigators in the project: 5

Call: SONATA BIS 3 - announced on 2013-06-14

Amount awarded: 1 500 000 PLN

Project start date (Y-m-d): 2014-06-10

Project end date (Y-m-d): 2020-02-09

Project duration:: 68 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Inkubator CO2 (30 000 PLN)
  2. Mikroskop stereoskopowy (20 000 PLN)
  3. Wtrząsarka laboratoryjne.

Information in the final report

  • Publication in academic press/journals (10)
  • Articles in post-conference publications (10)
  • Book publications / chapters in book publications (1)
  1. Fat and sugar - a dangerous duet. A comparative review on metabolic remodeling in rodent models of nonalcoholic fatty liver disease
    Authors:
    I.C.M. Simoes, J. Janikiewicz, J. Bauer, A. Karkucinska-Wieckowska, P. Kalinowski, A. Dobrzyń, A. Wolski, M. Pronicki, K. Zieniewicz, P. Dobrzyń, M. Krawczyk, H. Zischka, M.R. Wieckowski, Y. Potes
    Academic press:
    Nutrients (rok: 2019, tom: 11, strony: 2871), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/nu11122871 - link to the publication
  2. Interaction of mitochondria with the endoplasmic reticulum and plasma membrane in calcium homeostasis, lipid trafficking and mitochondrial structure
    Authors:
    J. Szymanski, J. Janikiewicz, B. Michalska, P. Patalas-Krawczyk, M. Perrone, W. Ziolkowski, J. Duszynski, P. Pinton, A. Dobrzyn, M.R. Wieckowski
    Academic press:
    Int J Mol Sci (rok: 2017, tom: 18, strony: 1576), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms18071576 - link to the publication
  3. Mitochondria-associated membranes in aging and senescence: structure, function, and dynamics
    Authors:
    J. Janikiewicz, J. Szymański, D. Malinska, P. Patalas-Krawczyk, B. Michalska, J. Duszyński, C. Giorgi, M. Bonora, A. Dobrzyn, M.R. Wieckowski
    Academic press:
    Cell Death Dis (rok: 2018, tom: 9, strony: 332), Wydawca: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/s41419-017-0105-5 - link to the publication
  4. Oleic acid increases the transcriptional activity of FoxO1 by promoting its nuclear translocation and β-catenin binding in pancreatic β-cells
    Authors:
    M. Jazurek-Ciesiolka, J. Janikiewicz, P. Dobrzyn, A. Dziewulska, K. Kozinski, A. Dobrzyn
    Academic press:
    Biochim Biophys Acta Mol Basis Dis (rok: 2019, tom: 1865, strony: 2753-2764), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bbadis.2019.06.018 - link to the publication
  5. Spotlight on epigenetics as a missing link between obesity and type 2 diabetes
    Authors:
    A.M. Dobosz, A. Dziewulska, A. Dobrzyń
    Academic press:
    Postepy Biochem (rok: 2018, tom: 64, strony: 157-165), Wydawca: Polskie Towarzystwo Biochemiczne
    Status:
    Published
    DOI:
    10.18388/pb.2018_126 - link to the publication
  6. The Good, the Bad, and the Ugly - role of the pancreas, endothelium, and adipose tissue axis in the management of pancreatic β-cell failure in obesity-related type 2 diabetes
    Authors:
    J. Janikiewicz, P. Pawelec, P. Kucharczyk, A. Dobrzyń
    Academic press:
    Postepy Biochem (rok: 2018, tom: 64, strony: 166-174), Wydawca: Polskie Towarzystwo Biochemiczne
    Status:
    Published
    DOI:
    10.18388/pb.2018_127 - link to the publication
  7. Fetal endocannabinoids orchestrate the organization of pancreatic islet microarchitecture
    Authors:
    K. Maleńczyk, E. Keimpema, F. Piscitelli, D. Calvigioni, P. Bjorklund, K. Mackie, V Di Marzo, TG Hokfelt, A. Dobrzyń, T. Harkany
    Academic press:
    Proc Natl Acad Sci USA (rok: 2015, tom: 112, strony: E6185-6194), Wydawca: The National Academy of Sciences of the United States of America
    Status:
    Published
    DOI:
    10.1073/pnas.1519040112 - link to the publication
  8. Stearoyl-CoA desaturase 1 activity determines the maintenance of DNMT1-mediated DNA methylation patterns in pancreatic β-cells
    Authors:
    A.M. Dobosz, J. Janikiewicz, A.M. Borkowska, A. Dziewulska, E. Lipiec, P. Dobrzyn, W.M. Kwiatek, A. Dobrzyn
    Academic press:
    Int J Mol Sci (rok: 2020, tom: 21, strony: 6844), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21186844 - link to the publication
  9. Adipose- and muscle derived Wnts trigger pancreatic beta-cell adaptation to systemic insulin resistance
    Authors:
    K. Koziński, M. Jazurek, P. Dobrzyń, J. Janikiewicz, K. Kolczynska, A. Gajda, A. Dobrzyń
    Academic press:
    Sci Rep (rok: 2016, tom: 6, strony: 31553), Wydawca: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/srep31553 - link to the publication
  10. High-throughput approaches onto uncover (epi)genomic architecture of type 2 diabetes
    Authors:
    A. Dziewulska, A.M. Dobosz, A. Dobrzyn
    Academic press:
    Genes (rok: 2018, tom: 9, strony: 374), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/genes9080374 - link to the publication
  1. Role of stearoyl-CoA desaturase in regulation of pancreatic islets organogenesis
    Authors:
    A. Dobosz, A. Dziewulska, B. Krupa, J. Janikiewicz, A. Dobrzyn
    Conference:
    International Conference on the Bioscience of Lipids (rok: 2017, ), Wydawca: ICBL
    Data:
    konferencja 10 - 14 wrzesień
    Status:
    Published
  2. Pancreatic beta-cells plasticity - the role of stearoyl-CoA desaturase 1
    Authors:
    A. Dobosz, J. Janikiewicz, A. Dziewulska, A. Dobrzyn
    Conference:
    42nd FEBS Congress (rok: 2017, ), Wydawca: Federation of European Biochemical Societes
    Data:
    konferencja 10 - 14 wrzesień
    Status:
    Published
  3. Compromised identity of pancreatic islet cells – role of stearoyl-CoA desaturase 1 in epigenetic control of gene expression
    Authors:
    A.M. Dobosz, J. Janikiewicz, A. Dziewulska, A. Dobrzyn
    Conference:
    3rd Central European Biomedical Congress (rok: 2018, ), Wydawca: CBEC
    Data:
    konferencja 15 - 18 wrzesień
    Status:
    Published
  4. Stearoyl-CoA desaturase 1 regulates DNA methylation and histone acetylation patterns in pancreatic islets
    Authors:
    A. Dobosz, A. Dziewulska, B. Krupa, A. Dobrzyń
    Conference:
    FEBS Workshop on Chromatin Proteomics (rok: 2016, ), Wydawca: Federation of European Biochemical Societes
    Data:
    konferencja 3 - 8 październik
    Status:
    Published
  5. DNA methylation level is regulated by stearoyl-CoA desaturase 1 in pancreatic beta-cells but not in alpha-cells
    Authors:
    A. Dobosz, A. Dziewulska, B. Krupa, A. Dobrzyń
    Conference:
    Game of Epigenomics Conference (rok: 2016, ), Wydawca: Ruder Boskovic Institute
    Data:
    konferencja 24 - 28 kwiecień
    Status:
    Published
  6. Role of stearoyl-CoA desaturase 1 in epigenetic control of pancreatic islet cells identity
    Authors:
    A. Dobosz, J. Janikiewicz, A. Borkowska, A. Dziewulska, W.M. Kwiatek, A. Dobrzyn
    Conference:
    The 43rd FEBS Congress (rok: 2018, ), Wydawca: Federation of European Biochemical Societes
    Data:
    konferencja 7 - 12 lipiec
    Status:
    Published
  7. Inhibition of stearoyl-CoA desaturase 1 affects palmitate-derived autophagy and lipid droplet homeostasis in pancreatic beta cells
    Authors:
    J. Janikiewicz, K. Hanzelka, A. Dziewulska, K. Koziński, P. Dobrzyń, T. Bernaś, A. Dobrzyń
    Conference:
    6th European Workshop on Lipid Mediators (rok: 2016, ), Wydawca: Goethe University in Frankfurt
    Data:
    konferencja 27 - 30 wrzesień
    Status:
    Published
  8. Lipid-derived loss of pancreatic b-cell identity – the role of stearoyl-CoA desaturase 1
    Authors:
    A.M. Dobosz, J. Janikiewicz, A. Dziewulska, A. Dobrzyń
    Conference:
    44th FEBS Congress (rok: 2019, ), Wydawca: Wiley
    Data:
    konferencja 6 - 11 lipiec
    Status:
    Published
  9. Role of stearoyl-CoA desaturase 1 in epigenetic regulation of gene expression in pancreatic islets
    Authors:
    A. Dobosz, A. Dziewulska, B. Krupa, A. Dobrzyn
    Conference:
    FEBS Advanced Lecture Course on Nuclear Receptors and Epigenomic Mechanisms in Human Disease and Aging (rok: 2017, ), Wydawca: FEBS
    Data:
    konferencja 27 sierpień - 1 wrzesień
    Status:
    Published
  10. Stearoyl-CoA desaturase 1 – a novel player in regulation of pancreatic b-cell identity
    Authors:
    A.M. Dobosz, J. Janikiewicz, A. Dziewulska, K. Kolczynska, A. Dobrzyń
    Conference:
    60th International Conference on the Bioscience of Lipids (rok: 2019, ), Wydawca: ICBL
    Data:
    konferencja 17 - 21 czerwiec
    Status:
    Published
  1. Mitochondria and reactive oxygen species in aging and age-related diseases
    Authors:
    C. Giorgi, S. Marchi, I.C.M. Simoes, Z. Ren, G. Morciano, M. Perrone, P. Patalas-Krawczyk, S. Borchard, P. Jędrak, K. Pierzynowska, J. Szymański, D.Q. Wang, P. Portincasa, G. Węgrzyn, H. Zischka, P. Dobrzyn, M. Bonora, J. Duszynski, A. Rimessi, A. Karkucinska-Wieckowska, A. Dobrzyn, G. Szabadkai, B. Zavan, P.J. Oliveira, V.A. Sardao, P. Pinton, M.R. Wieckowski
    Book:
    Int Rev Cell Mol Biol (rok: 2018, tom: 340, strony: 209-344), Wydawca: Elsevier
    Status:
    Published
    DOI:
    link to the publication

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