The role of the 5' non-coding regions of p53 mRNA transcripts, which are synthesized from various transcription promoters and use alternative initiation sites in generating p53 protein isoforms
2013/09/B/NZ1/01884
Keywords
Descriptors
- NZ1_1: Biologia molekularna
- NZ1_2: Biochemia
- NZ1_4: Biologia strukturalna
Panel
NZ1 – Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology
Host institution
Instytut Chemii Bioorganicznej PAN
Voivodeship: wielkopolskie
Principal investigator (from the host institution)
Number of co-investigators in the project: 7
Call
OPUS 5 – announced on 2013-03-15
- Amount awarded
- 798 000 PLN
- Project start date
- 2014-02-13
- Project end date
- 2017-08-12
- Project duration
- 42 months (the same as in the proposal)
- Project status
- Project settled
Equipment purchased [PL]
- Komputer z drukarką. Cost: 6 000 PLN
- Wielofunkcyjny czytnik luminescencji, fluorescencji i absorbancji. Cost: 90 000 PLN
Information in the final report
Publication in academic press/journals (4)
-
Variants of the 5′-terminal region of p53 mRNA influence the ribosomal scanning and translation efficiency
- Authors:
- Paulina Zydowicz-Machtel, Agata Swiatkowska, Łukasz Popenda, Agnieszka Gorska & Jerzy Ciesiołka
- Academic press:
- Scientific Reports (year: 2018, volume: 8, pages: 1533), Publisher: NATURE PUBLISHING GROUP, MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
- Status:
- Published
- DOI:
- 10.1038/s41598-018-20010-2 – link to the publication
-
The role of the 5' terminal region of p53 mRNA in the p53 gene expression.
- Authors:
- A. Świątkowska, P. Żydowicz, J. Sroka, J. Ciesiołka.
- Academic press:
- Acta Biochimica Polonica (year: 2016, volume: 63(4), pages: 645-651), Publisher: Polskie Towarzystwo Biochemiczne, PAN: Komitet Biologii Molekularnej Komórki
- Status:
- Published
- DOI:
- 10.18388/abp.2016_1342 – link to the publication
-
The Role of Structural Elements of the 5'-Terminal Region of p53 mRNA in Translation under Stress Conditions Assayed by the Antisense Oligonucleotide Approach.
- Authors:
- A. Świątkowska, P. Żydowicz, A. Górska, J. Suchacka, M. Dutkiewicz, J. Ciesiołka
- Academic press:
- PLoS ONE (year: 2015, volume: 10(10), pages: e0141676), Publisher: San Francisco, California, and Cambridge, United Kingdom
- Status:
- Published
- DOI:
- 10.1371/journal.pone.0141676 – link to the publication
-
Length and secondary structure of the 5′ non-coding regions of mouse p53 mRNA transcripts - mouse as a model organism for p53 gene expression studies
- Authors:
- Joanna Szpotkowska, Agata Swiatkowska and Jerzy Ciesiołka
- Academic press:
- RNA Biology (year: 2019, volume: 16(1), pages: 25-41), Publisher: Taylor & Francis, Informa UK Limited, 5 Howick Place, London, SW1P 1WG
- Status:
- Published
- DOI:
- 10.1080/15476286.2018.1556084 – link to the publication
Articles in post-conference publications (7)
-
REGION NIEKODUJACY 5' mRNA GENU TP53 - STRUKTURA ORAZ ROLA W PROCESIE TRANSLACJI
- Authors:
- Jerzv Ciesiołka, Agata Swiątkowska, Paulina Żydowicz-Machtel, Joanna Sroka, Łukasz Popenda, Agnieszka Górska
- Conference:
- 60. Zjazd Naukowy Polskiego Towarzystwa Chemicznego (year: 2017, pages: 246), Publisher: Polskie Towarzystwo Chemiczne
- Date:
- conference 17 - 21 wrzesień
- Status:
- Published
-
Length of the 5' terminal region and structural context of the AUG1 start codon influence the ribosomal scanning and translation initiation of p53 mRNA.
- Authors:
- Paulina Żydowicz, Agata Świątkowska, Agnieszka Górska, Łukasz Popenda, Jerzy Ciesiołka
- Conference:
- EMBO Conference: Protein Synthesis and Translational Control (year: 2015, pages: p. 326), Publisher: EMBO
- Date:
- conference September 9-13
- Status:
- Published
-
Length and secondary structure of the 5' non-coding regions of p53 mRNA transcripts influence the translation of p53 protein and its Δ41p53 isoform in mouse
- Authors:
- Joanna Sroka, Agnieszka Górska, Aleksandra Kasprowicz, Jerzy Ciesiołka
- Conference:
- The Complex life of mRNA (year: 2016, pages: p. 291), Publisher: EMBO
- Date:
- conference October 5-8
- Status:
- Published
-
Identification and secondary structure characterization of the 5' non-coding regions of p53 mRNA transcripts in mouse
- Authors:
- Joanna Sroka, Agnieszka Górska, Aleksandra Kasprowicz, Jerzy Ciesiołka
- Conference:
- 2nd Congress BIO2016 Expanding beyond the limits (year: 2016, pages: p. 140), Publisher: Polskie Towarzystwo Biochemiczne, PAN: Komitet Biologii Molekularnej Komórki
- Date:
- conference September 13-16
- Status:
- Published
-
Variants of the S'-terminal region of p53 mRNA influence the ribosomal scanning and translation efficiency
- Authors:
- Zvdowicz-Machtel P, Swiatkowska A, Popenda L, G6rska A, Ciesiolka J
- Conference:
- RNAtion: Computational and Experimental RNA Biology Conference for Young Scientists (year: 2017, pages: 40), Publisher: Adam Mickiewicz University in Poznań, Poland
- Date:
- conference 18 - 19 September
- Status:
- Published
-
The role of structural elements of the 5'-terminal region of p53 mRNA in translation under stress conditions assayed by the antisense oligonucleotide approach.
- Authors:
- Agata Świątkowska, Paulina Żydowicz, Agnieszka Górska, Julia Suchacka, Mariola Dutkiewicz, Jerzy Ciesiołka
- Conference:
- RNA 2015: The Twentieth Annual Meeting of the RNA Society (year: 2015, pages: P 587), Publisher: The RNA Society
- Date:
- conference May 26–31
- Status:
- Published
-
Length of 5'UTR and structural context of AUG1 codon influence translation initiation of p53 mRNA.
- Authors:
- Paulina Żydowicz, Agata Świątkowska, Agnieszka Górska, Łukasz Popenda, Jerzy Ciesiołka
- Conference:
- EMBO Young Scientists' Forum (year: 2015, pages: p. 218), Publisher: EMBO
- Date:
- conference July 1-3
- Status:
- Published