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Information on the principal investigator and host institution

Information of the project and the call

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The role of the 5' non-coding regions of p53 mRNA transcripts, which are synthesized from various transcription promoters and use alternative initiation sites in generating p53 protein isoforms

2013/09/B/NZ1/01884

Keywords:

p53 protein isoforms mRNA non-coding region transcription translation regulation of expression

Descriptors:

  • NZ1_1: Molecular biology
  • NZ1_2: Biochemistry
  • NZ1_4: Structural biology

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Instytut Chemii Bioorganicznej PAN

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Jerzy Ciesiołka 

Number of co-investigators in the project: 7

Call: OPUS 5 - announced on 2013-03-15

Amount awarded: 798 000 PLN

Project start date (Y-m-d): 2014-02-13

Project end date (Y-m-d): 2017-08-12

Project duration:: 42 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Wielofunkcyjny czytnik luminescencji, fluorescencji i absorbancji (90 000 PLN)
  2. Komputer z drukarką (6 000 PLN)

Information in the final report

  • Publication in academic press/journals (4)
  • Articles in post-conference publications (7)
  1. Length and secondary structure of the 5′ non-coding regions of mouse p53 mRNA transcripts - mouse as a model organism for p53 gene expression studies
    Authors:
    Joanna Szpotkowska, Agata Swiatkowska and Jerzy Ciesiołka
    Academic press:
    RNA Biology (rok: 2019, tom: 16(1), strony: 25-41), Wydawca: Taylor & Francis, Informa UK Limited, 5 Howick Place, London, SW1P 1WG
    Status:
    Published
    DOI:
    10.1080/15476286.2018.1556084 - link to the publication
  2. The Role of Structural Elements of the 5'-Terminal Region of p53 mRNA in Translation under Stress Conditions Assayed by the Antisense Oligonucleotide Approach.
    Authors:
    A. Świątkowska, P. Żydowicz, A. Górska, J. Suchacka, M. Dutkiewicz, J. Ciesiołka
    Academic press:
    PLoS ONE (rok: 2015, tom: 10(10), strony: e0141676), Wydawca: San Francisco, California, and Cambridge, United Kingdom
    Status:
    Published
    DOI:
    10.1371/journal.pone.0141676 - link to the publication
  3. The role of the 5' terminal region of p53 mRNA in the p53 gene expression.
    Authors:
    A. Świątkowska, P. Żydowicz, J. Sroka, J. Ciesiołka.
    Academic press:
    Acta Biochimica Polonica (rok: 2016, tom: 63(4), strony: 645-651), Wydawca: Polskie Towarzystwo Biochemiczne, PAN: Komitet Biologii Molekularnej Komórki
    Status:
    Published
    DOI:
    10.18388/abp.2016_1342 - link to the publication
  4. Variants of the 5′-terminal region of p53 mRNA influence the ribosomal scanning and translation efficiency
    Authors:
    Paulina Zydowicz-Machtel, Agata Swiatkowska, Łukasz Popenda, Agnieszka Gorska & Jerzy Ciesiołka
    Academic press:
    Scientific Reports (rok: 2018, tom: 8, strony: 1533), Wydawca: NATURE PUBLISHING GROUP, MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
    Status:
    Published
    DOI:
    10.1038/s41598-018-20010-2 - link to the publication
  1. Length and secondary structure of the 5' non-coding regions of p53 mRNA transcripts influence the translation of p53 protein and its Δ41p53 isoform in mouse
    Authors:
    Joanna Sroka, Agnieszka Górska, Aleksandra Kasprowicz, Jerzy Ciesiołka
    Conference:
    The Complex life of mRNA (rok: 2016, ), Wydawca: EMBO
    Data:
    konferencja October 5-8
    Status:
    Published
  2. Identification and secondary structure characterization of the 5' non-coding regions of p53 mRNA transcripts in mouse
    Authors:
    Joanna Sroka, Agnieszka Górska, Aleksandra Kasprowicz, Jerzy Ciesiołka
    Conference:
    2nd Congress BIO2016 "Expanding beyond the limits" (rok: 2016, ), Wydawca: Polskie Towarzystwo Biochemiczne, PAN: Komitet Biologii Molekularnej Komórki
    Data:
    konferencja September 13-16
    Status:
    Published
  3. Length of 5'UTR and structural context of AUG1 codon influence translation initiation of p53 mRNA.
    Authors:
    Paulina Żydowicz, Agata Świątkowska, Agnieszka Górska, Łukasz Popenda, Jerzy Ciesiołka
    Conference:
    EMBO Young Scientists' Forum (rok: 2015, ), Wydawca: EMBO
    Data:
    konferencja July 1-3
    Status:
    Published
  4. Length of the 5' terminal region and structural context of the AUG1 start codon influence the ribosomal scanning and translation initiation of p53 mRNA.
    Authors:
    Paulina Żydowicz, Agata Świątkowska, Agnieszka Górska, Łukasz Popenda, Jerzy Ciesiołka
    Conference:
    EMBO Conference: Protein Synthesis and Translational Control (rok: 2015, ), Wydawca: EMBO
    Data:
    konferencja September 9-13
    Status:
    Published
  5. REGION NIEKODUJACY 5' mRNA GENU TP53 - STRUKTURA ORAZ ROLA W PROCESIE TRANSLACJI
    Authors:
    Jerzv Ciesiołka, Agata Swiątkowska, Paulina Żydowicz-Machtel, Joanna Sroka, Łukasz Popenda, Agnieszka Górska
    Conference:
    60. Zjazd Naukowy Polskiego Towarzystwa Chemicznego (rok: 2017, ), Wydawca: Polskie Towarzystwo Chemiczne
    Data:
    konferencja 17 - 21 wrzesień
    Status:
    Published
  6. Variants of the S'-terminal region of p53 mRNA influence the ribosomal scanning and translation efficiency
    Authors:
    Zvdowicz-Machtel P, Swiatkowska A, Popenda L, G6rska A, Ciesiolka J
    Conference:
    RNAtion: Computational and Experimental RNA Biology Conference for Young Scientists (rok: 2017, ), Wydawca: Adam Mickiewicz University in Poznań, Poland
    Data:
    konferencja 18 - 19 September
    Status:
    Published
  7. The role of structural elements of the 5'-terminal region of p53 mRNA in translation under stress conditions assayed by the antisense oligonucleotide approach.
    Authors:
    Agata Świątkowska, Paulina Żydowicz, Agnieszka Górska, Julia Suchacka, Mariola Dutkiewicz, Jerzy Ciesiołka
    Conference:
    RNA 2015: The Twentieth Annual Meeting of the RNA Society (rok: 2015, ), Wydawca: The RNA Society
    Data:
    konferencja May 26–31
    Status:
    Published

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