Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Molecular mechanism for the effects of stress hormones on development of drug addiction

2013/08/A/NZ3/00848

Keywords:

addiction glucocorticoids astroglia gene expression deep sequencing

Descriptors:

  • NZ3_5: Molecular neurobiology
  • NZ2_2: Genomics, transcriptomics, epigenomics
  • NZ4_8: Neuroendocrinology

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Instytut Farmakologii PAN

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Ryszard Przewłocki 

Number of co-investigators in the project: 10

Call: MAESTRO 4 - announced on 2012-12-15

Amount awarded: 2 990 000 PLN

Project start date (Y-m-d): 2013-09-26

Project end date (Y-m-d): 2019-09-25

Project duration:: 72 months (the same as in the proposal)

Project status: Project settled

Information in the final report

  • Publication in academic press/journals (12)
  • Articles in post-conference publications (17)
  • Book publications / chapters in book publications (3)
  1. Endogenous opioids regulate glucocorticoid-dependent stress-coping strategies in mice.
    Authors:
    Szklarczyk K, Korostynski M, Golda S, Piechota M, Ficek J, Przewlocki R
    Academic press:
    Neuroscience (rok: 2016, tom: 330, strony: 121-137), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.neuroscience.2016.05.034 - link to the publication
  2. High-throughput gene expression profiling of opioid-induced alterations in discrete brain areas.
    Authors:
    Michal Korostynski , Marcin Piechota , Slawomir Golda , and Ryszard Przewlocki
    Academic press:
    Methods Mol Biol (rok: 2015, tom: 1230, strony: 65-76), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/978-1-4939-1708-2_5 - link to the publication
  3. Mechanizmy uzależnienia od analgetyków opioidowych
    Authors:
    Ryszard Przewłocki
    Academic press:
    Medycyna Paliatywna w Praktyce (rok: 2017, tom: 45598, strony: 55–60), Wydawca: Via Medica
    Status:
    Published
    DOI:
    brak - link to the publication
  4. Astrocytes determine conditioned response to morphine via glucocorticoid receptor-dependent regulation of lactate release.
    Authors:
    Urszula Skupio, Magdalena Tertil, Wiktor Bilecki, Justyna Barut, Michal Korostynski, Slawomir Golda, Lucja Kudla, Lucja Wiktorowska, Joanna E. Sowa, Marcin Siwiec, Bartosz Bobula, Katarzyna Pels, Krzysztof Tokarski, Grzegorz Hess, Blazej Ruszczycki, Grzegorz Wilczynski, Ryszard Przewlocki
    Academic press:
    Neuropsychopharmacology (rok: 2020, tom: 45, strony: 404–415), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1038/s41386-019-0450-4 - link to the publication
  5. Functional characterization of a novel opioid, PZM21, and its influence on behavioural responses to morphine.
    Authors:
    Lucja Kudla, Ryszard Bugno, Urszula Skupio, Lucja Wiktorowska, Wojciech Solecki, Adam Wojtas, Krystyna Golembiowska, Ferenc Zádor, Sándor Benyhe, Szymon Buda, Wioletta Makuch, Barbara Przewlocka, Andrzej J. Bojarski, Ryszard Przewlocki
    Academic press:
    Br J Pharmacol. (rok: 2019, tom: 176, strony: 4434–4445), Wydawca: The British Pharmacological Society
    Status:
    Published
    DOI:
    10.1111/bph.14805 - link to the publication
  6. Noradrenergic and corticosteroid receptors regulate somatic and motivational symptoms of morphine withdrawal.
    Authors:
    Solecki WB, Kus N, Gralec K, Klasa A, Pradel K, Przewłocki R.
    Academic press:
    Behav Brain Res (rok: 2019, tom: 360, strony: 146-157), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bbr.2018.11.041 - link to the publication
  7. BEHAVIORAL AND MOLECULAR ALTERATIONS IN MICE RESULTING FROM CHRONIC TREATMENT WITH DEXAMETHASONE: RELEVANCE TO DEPRESSION
    Authors:
    U. SKUPIO, M. TERTIL, M. SIKORA, S. GOLDA, A. WAWRZCZAK-BARGIELA AND R. PRZEWLOCKI
    Academic press:
    Neuroscience (rok: 2015, tom: 286, strony: 141–150), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.neuroscience.2014.11.035. - link to the publication
  8. Glucocorticoid receptor signaling in astrocytes is required for aversive memory formation.
    Authors:
    Tertil M, Skupio U, Barut J, Dubovyk V, Wawrzczak-Bargiela A, Soltys Z, Golda S, Kudla L, Wiktorowska L, Szklarczyk K, Korostynski M, Przewlocki R, Slezak M.
    Academic press:
    Transl Psychiatry (rok: 2018, tom: 8(1):255, strony: 45302), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1038/s41398-018-0300-x - link to the publication
  9. Knockdown of the astrocytic glucocorticoid receptor in the central nucleus of the amygdala diminishes conditioned fear expression and anxiety
    Authors:
    Lucja Wiktorowska, Wiktor Bilecki, Magdalena Tertil, Lucja Kudla, Lukasz Szumiec, Marzena Mackowiak, Ryszard Przewlocki
    Academic press:
    Behavioural Brain Research (rok: 2021, tom: 402, strony: 113095), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bbr.2020.113095 - link to the publication
  10. Astroglial Knockout of Glucocorticoid Receptor Attenuates Morphine Withdrawal Symptoms, but Not Antinociception and Tolerance in Mice.
    Authors:
    Magdalena Tertil, Urszula Skupio, Lucja Kudla, Lucja Wiktorowska, Ryszard Przewlocki
    Academic press:
    Cellular and Molecular Neurobiology (rok: 2021, tom: -, strony: Online ahead of print), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s10571-021-01086-3 - link to the publication
  11. Behavioral and transcriptional patterns of protracted opioid self-administration in mice.
    Authors:
    Skupio U, Sikora M, Korostynski M, Wawrzczak-Bargiela A, Piechota M, Ficek J, Przewlocki R
    Academic press:
    Addiction Biology (rok: 2017, tom: 22(6), strony: 1802-1816), Wydawca: Society for the Study of Addiction
    Status:
    Published
    DOI:
    10.1111/adb.12449 - link to the publication
  12. TEMPORAL AND ANATOMIC PATTERNS OF IMMEDIATE-EARLY GENE EXPRESSION IN THE FOREBRAIN OF C57BL/6 AND DBA/2 MICE AFTER MORPHINE ADMINISTRATION
    Authors:
    Ziółkowska B, Gieryk A, Solecki W, Przewłocki R
    Academic press:
    Neuroscience (rok: 2015, tom: 284, strony: 107-124), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.neuroscience.2014.09.069. - link to the publication
  1. Astrocytic glucocorticoid receptor in central amygdala modulates stress-related behaviour in mice
    Authors:
    Łucja Wiktorowska, Wiktor Bilecki, Magdalena Tertil, Łucja Kudła, Łukasz Szumiec, Marzena Mackowiak, Ryszard Przewłocki
    Conference:
    NEURONUS 2020 IBRO Neuroscience Forum, online (rok: 2020, ), Wydawca: STUDENT NEUROSCIENCE SOCIETY 'NEURONUS' Institute of Zoology and Biomedical Research, Jagiellonian University
    Data:
    konferencja 8-11.12.2020
    Status:
    Published
  2. Cell type-specific transcriptional responses of neurons and astrocytes in vivo
    Authors:
    Magdalena Tertil, Sławomir Gołda, Marcin Piechota, Michał Korostyński, Agnieszka Wawrzczak-Bargieła, Urszula Skupio, Ryszard Przewłocki
    Conference:
    BIO 2014 1st Congress of Polish Biochemistry, Cell Biology, Biophysics and Bioinformatics (rok: 2014, ), Wydawca: Acta Biochimica Polonica, The Journal of the Polish Biochemical Society and of the Committee of Biochemistry and Biophysics Polish Academy of Sciences
    Data:
    konferencja 09-12 wrzesień 2014
    Status:
    Published
    DOI:
    link to the publication
  3. Comparison of gene transcription and depressive-like symptoms following chronic morphine and dexamethasone administration in mice
    Authors:
    Barut J., Skupio U., Marut L., Przewlocki P.
    Conference:
    Joint Conference The 13th International Symposium MOLECULAR BASIS OF PATHOLOGY AND THERAPY IN NEUROLOGICAL DISORDERS The 4th International Conference STEM CELLS: THERAPEUTIC OUTLOOK FOR CENTRAL NERVOUS SYSTEM DISORDERS (rok: 2016, ), Wydawca: Folia Neuropathologica 2016; 54/3
    Data:
    konferencja 17-18.11.2016
    Status:
    Published
  4. GLUCOCORTICOID RECEPTOR IN BEHAVIORAL EFFECTS OF OPIOIDS
    Authors:
    Łucja Kudła, Urszula Skupio, Łucja Marut, Magdalena Tertil, Agnieszka Wawrzczak‑Bargieła, Ryszard Przewłocki
    Conference:
    13th International Congress of Polish Neuroscience Society (rok: 2017, ), Wydawca: Nencki Institute of Experimental Biology i Polish Neuroscience Society
    Data:
    konferencja 28-30.08.2017
    Status:
    Published
  5. Glucocorticoid receptor regulates rewarding properties of morphine
    Authors:
    L.Marut, U.Skupio, R.Przewłocki
    Conference:
    30th ECNP Congress (rok: 2017, ), Wydawca: Elsevier
    Data:
    konferencja 2-5 wrzesień 2017
    Status:
    Published
    DOI:
    link to the publication
  6. Glucocorticoid receptor signaling in astrocytes mediates the acquisition and extinction of contextual aversive memory.
    Authors:
    Skupio U., Tertil M., Kudła Ł., Szklarczyk-Smolana K., Korostyński M., Ślęzak M., Przewłocki R.
    Conference:
    NEURONUS 2016. IBRO & IRUN Neuroscience Forum (rok: 2016, ), Wydawca: neuronusforum.pl
    Data:
    konferencja 22-24.04.2016
    Status:
    Published
  7. Glucocorticoid receptor-dependent signalling in astrocytes as target of opioid action
    Authors:
    Barut J, Skupio U, Tertil M, Golda S, Korostynski M, Piechota M, Marut L, Kudla L, Przewlocki R
    Conference:
    30th ECNP Congress, Paris (rok: 2017, ), Wydawca: European Neuropsychopharmacology
    Data:
    konferencja 2-5 września 2017
    Status:
    Published
  8. Opioid alterations of the reward circuit transcriptome involve glucocorticoid pathways within astrocytes.
    Authors:
    Przewłocki R., Gołda S., Piechota M., Skupio U., Korostyński M., Barut J., Tertil M.
    Conference:
    Neuroscience 2016 (rok: 2016, ), Wydawca: Society for Neuroscience
    Data:
    konferencja 12-16.11.2016
    Status:
    Published
  9. Astrocyte-specific transcriptional response to glucocorticoid receptor stimulation-metabolic implications
    Authors:
    M Tertil, S Golda, A Wawrzczak-Bargiela, M Korostynski, M Piechota, M Slezak, R Przewlocki
    Conference:
    GLIA MEETING BILBAO 2015 (rok: 2015, ), Wydawca: Wiley Periodicals, Inc.
    Data:
    konferencja 15-18.07.2015
    Status:
    Published
  10. Knockout of the glucocorticoid receptor in astrocytes alters contextual aversive memory in mice
    Authors:
    U.Skupio, L.Kudla, L.Marut, M.Tertil, J.Barut, S.Golda, M.Korostynski, M.Slezak, R.Przewlocki
    Conference:
    30th ECNP Congress (rok: 2017, ), Wydawca: Elsevier
    Data:
    konferencja 2-5 wrzesień 2017
    Status:
    Published
    DOI:
    link to the publication
  11. ANALYSIS OF MORPHINE-INDUCED GENE EXPRESSION IN THE MOUSE HIPPOCAMPUS
    Authors:
    Justyna Barut, Urszula Skupio, Łucja Marut, Magdalena Tertil, Sławomir Gołda, Ryszard Przewłocki
    Conference:
    13th International Congress of Polish Neuroscience Society (rok: 2017, ), Wydawca: Nencki Institute of Experimental Biology i Polish Neuroscience Society
    Data:
    konferencja 28-30.08.2017
    Status:
    Published
  12. MOLECULAR BIOMARKERS OF ADDICTION IN A MODEL OF LONG‑TERM MORPHINE SELF‑ADMINISTRATION IN MICE
    Authors:
    Urszula Skupio, Magdalena Sikora, Michał Korostyński, Agnieszka Wawrzczak‑Bargieła, Marcin Piechota, Ryszard Przewłocki
    Conference:
    13th International Congress of Polish Neuroscience Society (rok: 2017, ), Wydawca: Nencki Institute of Experimental Biology i Polish Neuroscience Society
    Data:
    konferencja 28-30.08.2017
    Status:
    Published
  13. Expression regulation of opioid propeptides and dopamine receptors in the mesostriatal system by chronic intake of palatable foods
    Authors:
    Ziolkowska B., Gieryk A., Martín-García E., Burokas A., Maldonado R., McDonald J., Dierssen M., Przewlocki R.
    Conference:
    Joint Conference The 13th International Symposium MOLECULAR BASIS OF PATHOLOGY AND THERAPY IN NEUROLOGICAL DISORDERS The 4th International Conference STEM CELLS: THERAPEUTIC OUTLOOK FOR CENTRAL NERVOUS SYSTEM DISORDERS (rok: 2016, ), Wydawca: Folia Neuropathologica 2016; 54/3
    Data:
    konferencja 17-18.11.2016
    Status:
    Published
  14. Molecular basis of astrocytic response to glucocorticoids: lentiviral vector-mediated RNA interference study
    Authors:
    Magdalena Tertil, Urszula Skupio, Agnieszka Wawrzczak-Bargieła, Sławomir Gołda, Michał Ślęzak, Ryszard Przewłocki
    Conference:
    Glia in Health & Disease (rok: 2014, ), Wydawca: Cold Spring Harbor Laboratory Meetings & Courses
    Data:
    konferencja 17-21 lipiec 2014
    Status:
    Published
  15. Morphine-induced gene expression changes in the mouse brain – focus on glucocorticoid receptor-dependent alterations
    Authors:
    J.Barut, U.Skupio, M.Tertil, S.Golda, R.Przewlocki
    Conference:
    30th ECNP Congress (rok: 2017, ), Wydawca: Elsevier
    Data:
    konferencja 2-5 wrzesień 2017
    Status:
    Published
    DOI:
    link to the publication
  16. GLUCOCORTICOID RECEPTOR STIMULATION MODULATES MORPHINE ADDICTION-LIKE SYMPTOMS
    Authors:
    Łucja Marut, Urszula Skupio, Ryszard Przewłocki
    Conference:
    13th International Congress of Polish Neuroscience Society (rok: 2017, ), Wydawca: Nencki Institute of Experimental Biology i Polish Neuroscience Society
    Data:
    konferencja 28-30.08.2017
    Status:
    Published
  17. The role of astrocytic glucocorticoid receptor in morphine withdrawal and conditioned place aversion
    Authors:
    L.Kudla, U.Skupio, L.Marut, M.Tertil, J.Barut, A.Wawrzczak-Bargiela, R.Przewlocki
    Conference:
    30th ECNP Congress (rok: 2017, ), Wydawca: Elsevier
    Data:
    konferencja 2-5 wrzesień 2017
    Status:
    Published
    DOI:
    link to the publication
  1. Stress and Opioid Systems.
    Authors:
    PRZEWŁOCKI R., Almeida O.F.X.
    Book:
    Hormones, Brain and Behavior. 3rd edition (rok: 2017, tom: Vol 1, strony: 225–260), Wydawca: Academic Press - Elsevier Inc.
    Status:
    Published
  2. Transcriptional effects of heroin and methamphetamine in the striatum.
    Authors:
    PRZEWŁOCKI R., KOROSTYŃSKI M., PIECHOTA M.
    Book:
    Neuropathology of Drug Addictions and Substance Misuse. (rok: 2016, tom: Vol. 1, strony: 933-943), Wydawca: Academic Press – Elsevier
    Status:
    Published
  3. Uzależnienia lekowe – epidemia uzależnień od opioidów
    Authors:
    RYSZARD PRZEWŁOCKI
    Book:
    Przyroda. Działalność człowieka. STUDIUM GENERALE (rok: 2019, tom: XXII, strony: 183-198), Wydawca: ATUT
    Status:
    Published

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