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Conserved RNA structural motifs in influenza virus: toward revealing viral RNA functions

2013/08/M/NZ1/01062

Keywords:

secondary structure RNA secondary structure prediction structure-function relationship in RNA RNA function influenza virus microarrays modified oligonucleotides

Descriptors:

  • NZ1_4: Structural biology
  • NZ1_1: Molecular biology
  • NZ1_2: Biochemistry

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Instytut Chemii Bioorganicznej PAN

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Elżbieta Kierzek 

Number of co-investigators in the project: 11

Call: HARMONIA 4 - announced on 2012-12-15

Amount awarded: 912 600 PLN

Project start date (Y-m-d): 2013-08-28

Project end date (Y-m-d): 2017-05-27

Project duration:: 45 months (the same as in the proposal)

Project status: Project settled

Information in the final report

  • Publication in academic press/journals (12)
  1. Microarrays for identifying binding sites and probing structure of RNAs
    Authors:
    R. Kierzek, D.H. Turner, E. Kierzek
    Academic press:
    NUCLEIC ACIDS RESEARCH (rok: 2015, tom: 43, strony: 45303), Wydawca: Oxford University Press
    Status:
    Published
    DOI:
    10.1093/nar/gku1303 - link to the publication
  2. Secondary Structure of a Conserved Domain in an Intron of Influenza A M1 mRNA
    Authors:
    T. Jiang, S.D. Kennedy, W.N. Moss, E. Kierzek, D.H. Turner
    Academic press:
    Biochemistry (rok: 2014, tom: 53, strony: 5236-5248), Wydawca: ACS Publications
    Status:
    Published
    DOI:
    10.1021/bi500611j - link to the publication
  3. TMV mutants with poly(A) tracts of different lengths demonstrate structural variations in 3 ' UTR affecting viral RNAs accumulation and symptom expression
    Authors:
    S. Guo, E. Kierzek, G. Chen, Y. Zhou & S. Wong
    Academic press:
    SCIENTIFIC REPORTS (rok: 2015, tom: 5, strony: 18412), Wydawca: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/srep18412 - link to the publication
  4. A Conserved Secondary Structural Element in the Coding Region of the Influenza A Virus Nucleoprotein (NP) mRNA Is Important for the Regulation of Viral Proliferation
    Authors:
    M. Soszynska-Jozwiak, P. Michalak, W.N. Moss, R. Kierzek, E. Kierzek
    Academic press:
    PLOS ONE (rok: 2015, tom: 10, strony: e0141132), Wydawca: Public Library of Science
    Status:
    Published
    DOI:
    10.1371/journal.pone.0141132 - link to the publication
  5. Structural determinants for alternative splicing regulation of the MAPT pre-mRNA
    Authors:
    J. Lisowiec, D. Magner; E. Kierzek, E. Lenartowicz, R. Kierzek
    Academic press:
    RNA BIOLOGY (rok: 2015, tom: 12, strony: 330-342), Wydawca: Landes Bioscience
    Status:
    Published
    DOI:
    10.1080/15476286.2015.1017214 - link to the publication
  6. The contribution of pseudouridine to stabilities and structure of RNAs
    Authors:
    E. Kierzek, M. Malgowska, J. Lisowiec, D. H. Turner, Z. Gdaniec and R. Kierzek
    Academic press:
    Nucleic Acids Research (rok: 2014, tom: 42, strony: 3492-3501), Wydawca: Oxford University Press
    Status:
    Published
    DOI:
    10.1093/nar/gkt1330 - link to the publication
  7. A Tandem Oligonucleotide Approach for SNP-Selective RNA Degradation Using Modified Antisense Oligonucleotides
    Authors:
    D. Magner, E. Biala, J. Lisowiec-Wachnicka, E. Kierzek, R. Kierzek
    Academic press:
    PLOS ONE (rok: 2015, tom: 10, strony: e0142139), Wydawca: Public Library of Science
    Status:
    Published
    DOI:
    10.1371/journal.pone.0142139 - link to the publication
  8. Antisense Oligonucleotides Targeting Influenza A Segment 8 Genomic RNA Inhibit Viral Replication
    Authors:
    E. Lenartowicz, A. Nogales, E. Kierzek, R. Kierzek, L. Martinez-Sobrido, D.H. Turner
    Academic press:
    Nucleic Acid Therapeutics (rok: 2016, tom: 26, strony: 277–285), Wydawca: Mary Ann Liebert, Inc.
    Status:
    Published
    DOI:
    10.1089/nat.2016.0619 - link to the publication
  9. Interplay of LNA and 2′‑O‑Methyl RNA in the Structure and Thermodynamics of RNA Hybrid Systems: A Molecular Dynamics Study Using the Revised AMBER Force Field and Comparison with Experimental Results
    Authors:
    I. Yildirim, E. Kierzek, R. Kierzek, and G. C. Schatz
    Academic press:
    The Journal of Physical Chemistry B (rok: 2014, tom: 118, strony: 14177-14187), Wydawca: ACS Publications
    Status:
    Published
    DOI:
    10.1021/jp506703g - link to the publication
  10. Self-Folding of Naked Segment 8 Genomic RNA of Influenza A Virus
    Authors:
    E. Lenartowicz, J. Kesy, A. Ruszkowska, M. Soszynska-Jozwiak, P. Michalak, W.N. Moss, D.H. Turner, DH, R. Kierzek, E. Kierzek
    Academic press:
    PloS One (rok: 2016, tom: 11, strony: e0148281), Wydawca: Public Library of Science
    Status:
    Published
    DOI:
    10.1371/journal.pone.0148281 - link to the publication
  11. Structural Aspects of the Antiparallel and Parallel Duplexes Formed by DNA, 2 '-O-Methyl RNA and RNA Oligonucleotides
    Authors:
    M. Szabat, T. Pedzinski, T. Czapik, E. Kierzek, R. Kierzek
    Academic press:
    PLOS ONE (rok: 2015, tom: 10, strony: e0143354), Wydawca: Public Library of Science
    Status:
    Published
    DOI:
    10.1371/journal.pone.0143354 - link to the publication
  12. Secondary structure model of the naked segment 7 influenza A virus genomic RNA
    Authors:
    A. Ruszkowska, E. Lenartowicz, W. N. Moss, R. Kierzek and E. Kierzek
    Academic press:
    Biochemical Journal (rok: 2016, tom: 473, strony: 4327-4348), Wydawca: Portland Press
    Status:
    Published
    DOI:
    10.1042/BCJ20160651 - link to the publication

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