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Inducible pluripotent stem cells as a tool in articular cartilage regeneration.

2012/07/E/NZ3/01819

Keywords

Descriptors

  • NZ3_8: Komórki macierzyste

Panel

NZ3 – Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution

Wielkopolskie Centrum Onkologii

Voivodeship: wielkopolskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr Wiktoria Maria Suchorska

Number of co-investigators in the project: 6

Call

SONATA BIS 2 – announced on 2012-09-15

Amount awarded
1 475 850 PLN
Project start date
2013-08-21
Project end date
2019-08-20
Project duration
72 months (the same as in the proposal)
Project status
Project settled

Equipment purchased [PL]

  1. Komora z laminarnym przepływem powietrza. Cost: 55 000 PLN
  2. System regałów klatkowych (12 pcs). Cost: 5 400 PLN
  3. Zestaw kaset do analizy RNA w aparacie Agilent Bioanalizer (5 pcs). Cost: 24 000 PLN
  4. Zestaw pipet automatycznych. (5 pcs). Cost: 10 000 PLN

Information in the final report

Publication in academic press/journals (21)

  1. Comparison of four protocols to generate chondrocyte-like cells from human induced pluripotent stem cells (hiPSCs)

    Authors:
    Augustyniak E, Suchorska WM, Richter M, Trzeciak T,
    Academic press:
    Stem Cell Rev (year: 2017, volume: 13, pages: 299-308), Publisher: Springer
    Status:
    Published
    DOI:
    10.1007/s12015-016-9708-y – link to the publication

  2. Bioimaging: An Useful Tool to Monitor Differentiation of Human Embryonic Stem Cells into Chondrocytes.

    Authors:
    Suchorska WM, Lach MS, Richter M, Kaczmarczyk J, Trzeciak T
    Academic press:
    Ann Biomed Eng. (year: 2016, volume: 44(5), pages: 1845-59), Publisher: Springer Link
    Status:
    Published
    DOI:
    10.1007/s10439-015-1443-z – link to the publication

  3. Gene expression profile in human induced pluripotent stem cells: Chondrogenic differentiation in vitro, part A.

    Authors:
    Suchorska WM, Augustyniak E, Richter M, Trzeciak T.
    Academic press:
    Mol Med Rep. (year: 2017, volume: May;15(5), pages: 2387-2401.), Publisher: Spandidos Publications
    Status:
    Published
    DOI:
    10.3892/mmr.2017.6334. – link to the publication

  4. Correlations between serum adipocytokine concentrations, disease stage, radiological status and total body fat content in the patients with primary knee osteoarthritis

    Authors:
    Magdalena Richter, Tomasz Trzeciak, Jakub Dalibor Rybka, Wiktoria Suchorska, Ewelina Augustyniak, Michał Lach, Małgorzata Kaczmarek, Jacek Kaczmarczyk
    Academic press:
    International Orthopaedics (year: 2017, volume: 41, pages: 983-989), Publisher: Springer
    Status:
    Published
    DOI:
    10.1007/s00264-016-3370-5 – link to the publication

  5. Actual strategies in human induced pluripotent stem cells (hiPSCs) differentiation – perspectives and challenges

    Authors:
    Ewelina Augustyniak, Katarzyna Kulcenty, Michał Lach, Igor Piotrowski , Wiktoria Maria Suchorska
    Academic press:
    Diagn Lab. Journal of Laboratory Diagnostics (year: 2016, volume: 52 (2), pages: 123-136), Publisher: Fundacja Rozwoju Diagnostyki Laboratoryjnej
    Status:
    Published
    DOI:
    link to the publication

  6. Directed differentiation of induced pluripotent stem cells into chondrogenic lineages for articular cartilage treatment

    Authors:
    Lach M., Trzeciak T., Richter M., Pawlicz J., Suchorska W.
    Academic press:
    Journal of Tissue Engineering (year: 2014, volume: vol. 5, pages: 46031), Publisher: SAGE
    Status:
    Published
    DOI:
    10.1177/2041731414552701 – link to the publication

  7. The role of growth factors in stem cell-directed chondrogenesis: a real hope for damaged cartilage regeneration

    Authors:
    Ewelina Augustyniak & Tomasz Trzeciak & Magdalena Richter & Jacek Kaczmarczyk & Wiktoria Suchorska
    Academic press:
    International Orthopaedics (SICOT) (year: 2015, volume: 39(5), pages: 995-1003), Publisher: Springer Link
    Status:
    Published
    DOI:
    10.1007/s00264-014-2619-0 – link to the publication

  8. Application of cell and biomaterial-based tissue engineering methods in the treatment of cartilage, menisci and ligament injuries.

    Authors:
    Trzeciak T, Richter M, Suchorska W, Augustyniak E, Lach M, Kaczmarek M, Kaczmarczyk J
    Academic press:
    Int Orthop. (year: 2016, volume: 40(3), pages: 615-24), Publisher: Springer Links
    Status:
    Published
    DOI:
    10.1007/s00264-015-3099-6. – link to the publication

  9. The role of exosomes in tumor progression and metastasis

    Authors:
    WM Suchorska, M Lach
    Academic press:
    Oncology Reports (year: 2016, volume: 35(3), pages: 1237-1244), Publisher: Spandidos
    Status:
    Published
    DOI:
    10.3892/or.2015.4507 – link to the publication

  10. Genetic stability of pluripotent stem cells during anti-cancer therapies

    Authors:
    Suchorska WM, Augustyniak E, Łukjanow M.
    Academic press:
    Exp Ther Med. (year: 2016, volume: 11(3), pages: 695–702), Publisher: Spandidos
    Status:
    Published
    DOI:
    10.3892/etm.2016.2993 – link to the publication

  11. Expression of Pluripotency Genes in Chondrocyte-Like Cells Differentiated from Human Induced Pluripotent Stem Cells.

    Authors:
    Stelcer E, Kulcenty K, Rucinski M, Jopek K, Trzeciak T, Richter M, Wroblewska JP, Suchorska WM.
    Academic press:
    Int J Mol Sci. (year: 2018, volume: Feb 12;19(2)., pages: piiE550), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms19020550. – link to the publication

  12. Chondrogenic differentiation in vitro of hiPSCs activates pathways engaged in limb development.

    Authors:
    Stelcer E, Kulcenty K, Rucinski M, Jopek K, Richter M, Trzeciak T, Suchorska WM.
    Academic press:
    Stem Cell Res. (year: 2018, volume: 30, pages: 53-60), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.scr.2018.05.006 – link to the publication

  13. Forced differentiation in vitro leads to stress-induced activation of DNA damage response in hiPSC-derived chondrocyte-like cells.

    Authors:
    Stelcer E, Kulcenty K, Rucinski M, Jopek K, Richter M, Trzeciak T, Suchorska WM.
    Academic press:
    Plos One (year: 2018, volume: 13(6), pages: 46040), Publisher: PLOS
    Status:
    Published
    DOI:
    10.1371/journal.pone.0198079 – link to the publication

  14. Chondrogenic Differentiation of Pluripotent Stem Cells under Controllable Serum-Free Conditions.

    Authors:
    Lach MS, Wroblewska J, Kulcenty K, Richter M, Trzeciak T, Suchorska WM.
    Academic press:
    Int J Mol Sci. (year: 2019, volume: Jun 2;20(11), pages: pii: E2711), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms20112711 – link to the publication

  15. Liquid Biopsy in Oligometastatic Prostate Cancer-A Biologist's Point of View.

    Authors:
    Stelcer E, Konkol M, Głȩboka A, Suchorska WM.
    Academic press:
    Front Oncol. (year: 2019, volume: Aug 14;9:775, pages: 46041), Publisher: Frontiers
    Status:
    Published
    DOI:
    10.3389/fonc.2019.00775 – link to the publication

  16. The Role of MicroRNAs in Early Chondrogenesis of Human Induced Pluripotent Stem Cells (hiPSCs).

    Authors:
    Stelcer E, Kulcenty K, Rucinski M, Jopek K, Richter M, Trzeciak T, Suchorska WM.
    Academic press:
    Int J Mol Sci (year: 2019, volume: sep 5;20(18), pages: pii: E4371), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms20184371 – link to the publication

  17. Gene expression profile in human induced pluripotent stem cells: Chondrogenic differentiation in vitro, part B.

    Authors:
    Augustyniak E, Suchorska WM, Trzeciak T, Richter M.
    Academic press:
    Mol Med Rep. (year: 2017, volume: May;15(5), pages: 2402-2414.), Publisher: Spandidos Publication
    Status:
    Published
    DOI:
    10.3892/mmr.2017.6335 – link to the publication

  18. Modified methods for efficiently differentiating human embryonic stem cells into chondrocyte-like cells

    Authors:
    Suchorska WM, Augustyniak E, Filas V, Richter M, Łukjanow M, Kaczmarczyk J
    Academic press:
    Post MeD i Hig Dośw (year: 2017, volume: Jun 19;71(0), pages: 500-509), Publisher: Instytut Immunologii i Terapii Doświadczalnej PAN
    Status:
    Published
    DOI:
    link to the publication

  19. A feeder- and xeno-free human induced pluripotent stem cell line obtained from primary human dermal fibroblasts with epigenetic repression of reprogramming factors expression: GPCCi001-A.

    Authors:
    Lach MS, Wroblewska JP, Augustyniak E, Kulcenty K, Suchorska WM.
    Academic press:
    Stem Cell Research (year: 2017, volume: Apr;20, pages: 34-37), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.scr.2017.02.004 – link to the publication

  20. Effect of cellular mass on chondrogenic differentiation during embryoid body formation.

    Authors:
    Lach MS, Kulcenty K, Jankowska K, Trzeciak T, Richter M, Suchorska WM.
    Academic press:
    Mol Med Rep. (year: 2018, volume: Sep;18(3), pages: 2705-2714), Publisher: Spandidos Publications
    Status:
    Published
    DOI:
    10.3892/mmr.2018.9272 – link to the publication

  21. Chondrocytes differentiated from human induced pluripotent stem cells: Response to ionizing radiation.

    Authors:
    Stelcer E, Kulcenty K, Suchorska WM.
    Academic press:
    PLoS One. 2018 Oct 23;13(10):e0205691 (year: 2018, volume: 13(10), pages: 46037), Publisher: PLOS
    Status:
    Published
    DOI:
    10.1371/journal.pone.0205691 – link to the publication

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Graphic design and implementation: Jakub Piotrowski