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The examination of isothiocyanates influence on cytotoxic and cytostatic effects of 5-fluorouracil in cancer cell lines in vitro.

2012/05/N/NZ5/02634

Keywords

Descriptors

  • NZ5_7: Leczenie chorób człowieka
  • NZ3_3: Apoptoza

Panel

NZ5 – Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution

Narodowy Instytut Leków

Voivodeship: mazowieckie

Other projects carried out by the institution »

Principal investigator (from the host institution)

Małgorzata Milczarek

Number of co-investigators in the project: 3

Call

PRELUDIUM 3 – announced on 2012-03-15

Amount awarded
100 000 PLN
Project start date
2013-03-27
Project end date
2015-03-26
Project duration
24 months (the same as in the proposal)
Project status
Project settled

Information in the final report

Publication in academic press/journals (2)

  1. Autophagic cell death and premature senescence: New mechanism of 5-fluorouracil and sulforaphane synergistic anticancer effect in MDA-MB-231 triple negative breast cancer cell line

    Authors:
    Małgorzata Milczarek, Katarzyna Wiktorska, Lidia Mielczarek, Mirosława Koronkiewicz, Aleksandra Dąbrowska, Katarzyna Lubelska, Dariusz Matosiuk, Zdzisław Chilmonczyk
    Status:
    Accepted for publication

  2. THE COMPARISON OF INDIRECT AND DIRECT TOXICITY TESTS IN THE ASSESSMENT OF DRUG INTERACTIONS

    Authors:
    Lidia Śliwka; Katarzyna Wiktorska, Piotr Suchocki, Szymon Mielczarek, Małgorzata Milczarek, Katarzyna Lubelska, Tomasz Cierpiał, Piotr Kiełbasiński, Anna Jaromin, Anna Flis, Zdzisław Chilmonczyk
    Status:
    Accepted for publication

Articles in post-conference publications (11)

  1. The mechanism of synergic interaction between sulforaphane and 5-fluorouracil in the breast cell line MDA-MB-231

    Authors:
    M.Milczarek, K. Wiktorska, L. Śliwka, K. Lubelska, D. Matosiuk, Z. Chilmonczyk
    Conference:
    The Ninth Multidisciplinary Conference on Drug Research (year: 2017, pages: 41), Publisher: Instytut Farmaceutytczny
    Date:
    conference 15-19.05.2017
    Status:
    Published

  2. 9.Autofagiczna śmierć komórki i starzenie przyspieszone –mechanizmy synergistycznego oddziaływania 5-fluorouracylu i sulforafanu w linii komórkowej raka sutka MDA-MB-231

    Authors:
    M. Milczarek, K. Wiktorska, L. Mielczarek, A. Dąbrowska, K. Lubelska, D. Matosiuk, Z. Chilmonczyk
    Conference:
    XXIII Naukowy Zjazd PTFarm (year: 2017, pages: 360), Publisher: PTFarm
    Date:
    conference 19-22.09.2017
    Status:
    Published

  3. Potęgowanie aktywności przeciwnowotworowej 5-fluorouracylu przez sulforafan w komórkach raka jelita grubego i raka sutka

    Authors:
    M. Milczarek, K. Wiktorska, K. Lubelska, L. Śliwka, D. Matosiuk, Z. Chilmonczyk
    Conference:
    III Ogólnopolska Konferencja Doktorantów i Młodych Naukowców Per scientiam ad salutem aegroti (year: 2014, pages: 12), Publisher: Samorząd Doktorantów
    Date:
    conference 9-10.05.2014
    Status:
    Published

  4. Sulforaphane analogues - new perspectives in cancer treatment ?

    Authors:
    19.K. Wiktorska, K. Lubelska, L. Śliwka, M.Milczarek, P. Krug, T. Cierpiał, P. Kiełbasiński, P.Suchocki, M.Mazur, Z. Chilmonczyk
    Conference:
    The Ninth Multidisciplinary Conference on Drug Research (year: 2016, pages: 46148), Publisher: Instytut Farmaceutyczny
    Date:
    conference 15-19.05.2016
    Status:
    Published

  5. p-21 mediated synergic cytostatic effects of combined treatment with 5-fluorouracil and sulforaphane

    Authors:
    M.Milczarek, K. Wiktorska, K. Lubelska, L. Śliwka, D. Matosiuk, Z. Chilmonczyk
    Conference:
    VII Konwersatorium Chemii Medycznej (year: 2015, pages: 67), Publisher: PTBI,PTCM
    Date:
    conference 17-19.09.2015
    Status:
    Published

  6. The mechanism of synergism between 5-fluorouracil and 2-oxohexyl isothiocyanate in the colon cancer cell line HT-29

    Authors:
    M. Milczarek, K. Wiktorska, K. Lubelska, L. Śliwka, D. Matosiuk, Z. Chilmonczyk
    Conference:
    Ninth International Conference of Anticancer Research (year: 2014, pages: 6060), Publisher: International Institute of Anticancer Research
    Date:
    conference 06-10.10. 2014
    Status:
    Published

  7. Synergic and additive types of interaction between 5-fluorouracil and 2-oxohexyl isothiocyanate in concurrent treatment in breast cancer cells and not in colon cancer cells

    Authors:
    M. Milczarek, K. Wiktorska, K. Lubelska, L. Śliwka, D. Matosiuk, Z. Chilmonczyk
    Conference:
    1st Congress of the Polish Biochemistry, Cell Biology, Biophysics and Bioinformatics (year: 2014, pages: 58), Publisher: Acta Biochemica Polonica
    Date:
    conference 09-12.09.2014
    Status:
    Published
    DOI:
    link to the publication

  8. Comparison of combined effects of 5-fluorouracil and allysin after concurrent treatment in colon and breast cancer cells lines.

    Authors:
    Milczarek M., Wiktorska K., Lubelska K., Śliwka L., Matosiuk D., Chilmonczyk Z.
    Conference:
    The Ninth Multidisciplinary Conference on Drug Research (year: 2014, pages: 49), Publisher: brak
    Date:
    conference 12-14.05.2014
    Status:
    Published
    DOI:
    link to the publication

  9. Wpływ nowej pochodnej sulforafanu - izotiocyjanianu 2-oksoheptylu na aktywność przeciwnowotworową 5-fluorouracylu w komórkach raka sutka i jelita grubego

    Authors:
    Milczarek M., Wiktorska K., Lubelska K., Śliwka L., Matosiuk D., Chilmonczyk Z.
    Conference:
    II Studencka Konferencja Biologii Medycznej: Biofuzje. (year: 2014, pages: 67), Publisher: -
    Date:
    conference 23-25.05.2014
    Status:
    Published

  10. SELECTIVE, SYNERGIC AND ADDITIVE INTERACTION TYPES BETWEEN 5-FLUOROURACIL AND 2-OXOHEXYL ISOTHIOCYANATE AFTER SEQUENTIAL TREATMENT IN COLON CANCER CELL LINES

    Authors:
    Milczarek M., Wiktorska K., Lubelska K., Śliwka L., Matosiuk D., Chilmonczyk Z.
    Conference:
    ESMO 16th World Congress on Gastrointestinal Cancer (year: 2014, pages: ii70), Publisher: Annals of Oncology
    Date:
    conference 25-28.06.2014
    Status:
    Published
    DOI:
    link to the publication

  11. Potęgowanie cytotoksyczności 5-fluorouracylu przez sulforafan w komórkach nowotworowych

    Authors:
    M. Milczarek, K. Wiktorska, K. Lubelska, L. Śliwka, D. Matosiuk, Z. Chilmonczyk
    Conference:
    V Lubelskie Sympozjum Doktorantów Nauk Farmaceutycznych (year: 2014, pages: 28), Publisher: LTWNF
    Date:
    conference 13.06.2014
    Status:
    Published
    DOI:
    link to the publication

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