Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Identification of triple negative breast cancer with inactive DNA damage repair pathway by homologous recombination based on RT-PCR arrays and computerized analysis of protein expression.

2012/05/D/NZ5/01846

Keywords:

breast cancer PARP BRCA1 triple-negative subtype targeted therapy homologous recombination

Descriptors:

  • NZ5_3: Pathogenesis of human diseases
  • NZ5_7: Human disease treatment
  • NZ5_9: Other related subjects

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Pomorski Uniwersytet Medyczny w Szczecinie, Wydział Lekarski z Oddziałem Nauczania w Języku Angielskim

woj. zachodniopomorskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Paweł Domagała 

Number of co-investigators in the project: 2

Call: SONATA 3 - announced on 2012-03-15

Amount awarded: 487 500 PLN

Project start date (Y-m-d): 2013-02-20

Project end date (Y-m-d): 2016-02-19

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Stacja robocza do komputerowej analizy ekspresji białek (25 000 PLN)
  2. Mikrotom rotacyjny SRM200.
  3. Spektrofotometr NanoDrop 2000 wraz z oprogramowaniem (60 000 PLN)

Information in the final report

  • Publication in academic press/journals (3)
  • Articles in post-conference publications (3)
  1. Pathological complete response after cisplatin neoadjuvant therapy is associated with the downregulation of DNA repair genes in BRCA1-associated triple-negative breast cancers
    Authors:
    Paweł Domagała, Jolanta Hybiak, Janusz Ryś, Tomasz Byrski, Cezary Cybulski, Jan Lubiński
    Academic press:
    Oncotarget (rok: 2016, tom: 7, strony: 68662-68673), Wydawca: Impact Journals
    Status:
    Published
    DOI:
    10.18632/oncotarget.11900 - link to the publication
  2. Prevalence of Germline Mutations in Genes Engaged in DNA Damage Repair by Homologous Recombination in Patients with Triple-Negative and Hereditary Non- Triple-Negative Breast Cancers
    Authors:
    Paweł Domagała, Anna Jakubowska, Katarzyna Jaworska-Bieniek, Katarzyna Kaczmarek, Katarzyna Durda, Agnieszka Kurlapska, Cezary Cybulski, Jan Lubiński
    Academic press:
    PloS One (rok: 2015, tom: 10(6), strony: e0130393), Wydawca: Public Library of Science
    Status:
    Published
    DOI:
    10.1371/journal.pone.0130393 - link to the publication
  3. BRCA1/2-negative hereditary triple-negative breast cancers exhibit BRCAness
    Authors:
    Pawel Domagala, Jolanta Hybiak, Cezary Cybulski, Jan Lubinski
    Academic press:
    International Journal of Cancer (rok: 2017, tom: 140, strony: 1545–1550), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/ijc.30570 - link to the publication
  1. DNA repair pathway in BRCAX and BRCA1/2-associated hereditary triple-negative breast cancers.
    Authors:
    Paweł Domagała, Jolanta Hybiak, Cezary Cybulski
    Conference:
    Pathology - breaking barriers in medicine. 27th European Congress of Pathology, Belgrade, Serbia (rok: 2015, ), Wydawca: Springer
    Data:
    konferencja 5 - 9 September 2015
    Status:
    Published
  2. Pathological complete response after cisplatin neoadjuvant therapy is associated with the downregulation of DNA repair genes in BRCA1-associated triple-negative breast cancers
    Authors:
    Pawel Domagala, Jolanta Hybiak, Janusz Rys, Tomasz Byrski, Cezary Cybulski, Jan Lubinski
    Conference:
    28th Congress of the European Society of Pathology, Cologne, Germany. (rok: 2016, ), Wydawca: Springer
    Data:
    konferencja 25-29 wrzesień 2016
    Status:
    Published
  3. Prevalence of germline mutations in genes engaged in DNA damage repair by homologous recombination in patients with triple-negative and herediatry non-triple-negative breast cancers.
    Authors:
    Paweł Domagała, Anna Jakubowska, Katarzyna Jaworska-Bieniek, Katarzyna Kaczmarek, Katarzyna Durda, Agnieszka Kurlapska, Cezary Cybulski, Jan Lubiński.
    Conference:
    Pathology - breaking barriers in medicine. 27th European Congress of Pathology, Belgrade, Serbia. (rok: 2015, ), Wydawca: Springer
    Data:
    konferencja 5 - 9 September 2015
    Status:
    Published

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