Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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MicroRNA-dependent regulation of adhesion-related molecules in clear cell renal cell carcinoma: the search for markers of invasion and therapeutic molecules using multiple gene expresion assays.

2012/05/B/NZ5/01541

Keywords:

clear cell renal cell carcinoma microRNA cell adhesion cell adhesion molecules (CAMs) extracellular matrix (ECM) invasion

Descriptors:

  • NZ5_1: Etiology of human diseases
  • NZ3_14: Other related subjects
  • NZ2_12: Other related subjects

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Centrum Medyczne Kształcenia Podyplomowego

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Agnieszka Piekiełko-Witkowska 

Number of co-investigators in the project: 5

Call: OPUS 3 - announced on 2012-03-15

Amount awarded: 1 093 494 PLN

Project start date (Y-m-d): 2013-02-20

Project end date (Y-m-d): 2016-02-19

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Wirówka do probówek PCR pojedynczych i w paskach oraz do probówek typu Eppendorf (1,5ml).
  2. Wirówka do płytek do real-time PCR (4 300 PLN)

Information in the final report

  • Publication in academic press/journals (5)
  • Articles in post-conference publications (11)
  1. Induction of type 1 iodothyronine deiodinase expression inhibits proliferation and migration of renal cancer cells
    Authors:
    Piotr Poplawski, Beata Rybicka, Joanna Boguslawska, Katarzyna Rodzik, Theo J. Visser, Alicja Nauman, Agnieszka Piekielko-Witkowska
    Academic press:
    Molecular and Cellular Endocrinology (rok: 2017, tom: 442, strony: 58-67), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.mce.2016.12.004 - link to the publication
  2. Protein kinases that phosphorylate splicing factors: Roles in cancer development, progression and possible therapeutic options
    Authors:
    Alicja Czubatya, Agnieszka Piekiełko-Witkowska
    Academic press:
    International Journal of Biochemistry and Cell Biology (rok: 2017, tom: 91, strony: 102-115), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.biocel.2017.05.024 - link to the publication
  3. TGF-b1 targets a microRNA network that regulates cellular adhesion and migration in renal cancer
    Authors:
    Joanna Bogusławska, Katarzyna Rodzik, Piotr Popławski, Hanna Kędzierska, Beata Rybicka, Elżbieta Sokół, Zbigniew Tański, Agnieszka Piekiełko-Witkowska
    Academic press:
    Cancer Letters (rok: 2018, tom: 412, strony: 155-169), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.019 - link to the publication
  4. Epigenetic Regulation of Thyroid Hormone Receptor Beta in Renal Cancer
    Authors:
    Wojcicka A, Piekielko-Witkowska A, Kedzierska H, Rybicka B, Poplawski P, Boguslawska J, Master A, Nauman A
    Academic press:
    Plos One (rok: 2014, tom: 9, strony: e97624), Wydawca: Plos Media
    Status:
    Published
    DOI:
    10.1371/journal.pone.0097624 - link to the publication
  5. Expression of genes involved in cellular adhesion and extracellular matrix remodeling correlates with poor survival of patients with renal cancer
    Authors:
    Boguslawska J, Kedzierska H, Poplawski P, Rybicka B, Tanski Z, Piekielko-Witkowska A.
    Academic press:
    Journal of Urology (rok: 2016, tom: 195, strony: 45302), Wydawca: ELSEVIER SCIENCE INC 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
    Status:
    Published
    DOI:
    10.1016/j.juro.2015.11.050. - link to the publication
  1. SRSF2 splicing factor significantly contributes to the regulation of apoptosis in clear cell renal cell carcinoma (ccRCC)
    Authors:
    H. Kędzierska, P. Popławski, G. Hoser, B. Rybicka, K. Rodzik, E. Sokół, J. Bogusławska, Z. Tański, A. Piekiełko-Witkowska
    Conference:
    7th International Conference of Contemporary Oncology: Personalized Cancer Medicine and Big Data Analysis, part of the Cancer – a challenge of the 21st century (rok: 2015, ), Wydawca: Termedia
    Data:
    konferencja 25-27 marca 2015
    Status:
    Published
  2. TGF-beta-1-related changes in expression of genes involved in cellular adhesion and ECM remodelling are associated with worse survival rate of renal cancer patients
    Authors:
    Joanna Boguslawska, Hanna Kedzierska, Beata Rybicka, Piotr Poplawski, Zbigniew Tanski, Agnieszka Piekielko-Witkowska
    Conference:
    The 6th EMBO Meeting (rok: 2015, ), Wydawca: EMBO
    Data:
    konferencja 5-8 września 2015
    Status:
    Published
  3. microRNA-dependent regulation of expression of splicing factors in renal cell carcinoma (RCC)
    Authors:
    Joanna Bogusławska, Elżbieta Sokół, Beata Rybicka, Katarzyna Rodzik, Piotr Popławski, Alicja Czubaty, Hanna Kędzierska, Zbigniew Tański, Agnieszka Piekiełko-Witkowska
    Conference:
    Rak nerki, Rak prostaty 2015 - nowe wyzwania (rok: 2015, ), Wydawca: Fundacja Onkologii Doświadczalnej i Klinicznej
    Data:
    konferencja 23-24.10.2015
    Status:
    Published
  4. MicroRNA and alternative splicing regulate the expression of SRSF2 in renal cancer
    Authors:
    Sokol E, Boguslawska J, Kedzierska H, Poplawski P, Rodzik K, Rybicka B, Tanski Z, Piekielko-Witkowska A
    Conference:
    40th Congress of The Federation of European Biochemical Societies (FEBS) (rok: 2015, ), Wydawca: Wiley Blackwell/Federation of European Biochemical Societies
    Data:
    konferencja 4-9 lipca 2015
    Status:
    Published
  5. Re-introduction of type 1 iodothyronine deiodinase in renal cancer cells affects their migration and expression of adhesion-related genes.
    Authors:
    P. Popławski, J. Bogusławska, H. Kędzierska, B. Rybicka, Z. Tański, T.J. Visser, A. Nauman, A. Piekiełko-Witkowska
    Conference:
    17th European Congress of Endocrinology (rok: 2015, ), Wydawca: Bioscientifica
    Data:
    konferencja 16-20 maja 2015
    Status:
    Published
    DOI:
    link to the publication
  6. A panel of 20 genes involved in cellular adhesion and ECM remodelling distinguishes renal cancer and control samples.
    Authors:
    Joanna Boguslawska, Hanna Kędzierska, Beata Rybicka, Piotr Poplawski, Zbigniew Tanski, Alicja Nauman, Agnieszka Piekielko-Witkowska
    Conference:
    23rd Biennial Congress of the European Association for Cancer Research EACR-23: From Basic Research to Personalised Cancer Treatment (rok: 2014, ), Wydawca: Elsevier, The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, UK
    Data:
    konferencja 5-8 lipca 2014
    Status:
    Published
    DOI:
    link to the publication
  7. Disturbed expression of molecules involved in cell adhesion in renal cancer-derived cell lines
    Authors:
    Rodzik K, Boguslawska J, Sokol E, Piekielko-Witkowska A
    Conference:
    18th Symposium for Biology Students in Europe (rok: 2015, ), Wydawca: SymBioSE
    Data:
    konferencja 23-32 lipca 2015
    Status:
    Published
  8. MicroRNAs-mediated regulation of cell adhesion in renal cell cancer
    Authors:
    Joanna Bogusławska, Piotr Popławski, Beata Rybicka, Katarzyna Rodzik, Zbigniew Tański, Agnieszka Piekiełko-Witkowska
    Conference:
    Gliwice Scientific Meetings (rok: 2015, ), Wydawca: Association for the Support of Cancer Research
    Data:
    konferencja 20-21 listopada 2015
    Status:
    Published
  9. Re-expression of type 1 iodothyronine deiodinase reduces proliferation in renal cancer cells
    Authors:
    Piotr Popławski, Agnieszka Piekiełko-Witkowska
    Conference:
    38th Annual Meeting of the European Thyroid Association (rok: 2014, ), Wydawca: Karger
    Data:
    konferencja 6-10.09.2014
    Status:
    Published
    DOI:
    link to the publication
  10. SRSF2 splicing factor contributes to regulation of apoptosis in clear cell renal cell carcinoma (ccRCC)
    Authors:
    H. Kędzierska, P. Popławski, B. Rybicka, J.Bogusławska, Z. Tański, A. Piekiełko-Witkowska
    Conference:
    BIO2014: 1st Congress of the Polish Biochemistry, Cell Biology, Biophysics and Bioinformatics (rok: 2014, ), Wydawca: Polish Biochemical Society and the Committee of Biochemistry and Biophysics Polish Academy of Sciences
    Data:
    konferencja 9-12 września 2014
    Status:
    Published
    DOI:
    link to the publication
  11. miR-25-3p contributes to deregulated levels of ITGA5 and COL5A1 in renal cancer, possibly influencing cancerous adhesion
    Authors:
    Joanna Bogusławska, Katarzyna Rodzik, Piotr Popławski, Hanna Kędzierska, Beata Rybicka, Zbigniew Tański, Elżbieta Sokół, Agnieszka Piekiełko-Witkowska
    Conference:
    40th Congress of The Federation of European Biochemical Societies (FEBS) (rok: 2015, ), Wydawca: Wiley Blackwell/Federation of European Biochemical Societies
    Data:
    konferencja 4-9 lipca 2015
    Status:
    Published

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