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The role of Parkin in exogenous Alpha-synuclein-induced cell death. Implications for pathogenesis of Parkinson's disease and other synucleinopathies.

2012/05/B/NZ3/02047

Keywords

Descriptors

  • NZ3_5: Neurobiologia molekularna
  • NZ3_7: Przekaźnictwo sygnału

Panel

NZ3 – Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

Voivodeship: mazowieckie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr hab. Agata Adamczyk

Number of co-investigators in the project: 6

Call

OPUS 3 – announced on 2012-03-15

Amount awarded
450 200 PLN
Project start date
2013-02-11
Project end date
2016-02-10
Project duration
36 months (the same as in the proposal)
Project status
Project settled

Equipment purchased [PL]

  1. Komputer z oprogramowaniem GraphPad. Cost: 7 000 PLN
  2. System do transfekcji (elektroporacji);. Cost: 35 000 PLN

Information in the final report

Publication in academic press/journals (3)

  1. Extracellular alpha-synuclein induces calpain-dependent overactivation of cyclin-dependent kinase 5 in vitro.

    Authors:
    Czapski GA, Gąssowska M, Wilkaniec A, Cieślik M, Adamczyk A.
    Academic press:
    FEBS Lett. (year: 2013, volume: 587(18), pages: 3135-3141), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.febslet.2013.07.053. – link to the publication

  2. Potent effects of alkaloid- rich extract from Huperzia selago against sodium nitroprusside-evoked PC 12 cells damage via attenuation of oxidative stress and apoptosis.

    Authors:
    Anna Lenkiewicz, Grzegorz Czapski, Henryk Jęśko, Anna Wilkaniec, Wojciech Szypuła, Agnieszka Pietrosiuk, Agata Adamczyk
    Academic press:
    Folia Neuropathol. (year: 2016, volume: 54(2), pages: 156-166), Publisher: Termedia
    Status:
    Published
    DOI:
    10.5114/fn.2016.60361 – link to the publication

  3. Extracellular α-synuclein leads to microtubule destabilization via GSK-3β-dependent Tau phosphorylation in PC12 cells

    Authors:
    Gąssowska M, Czapski GA, Pająk B, Cieślik M, Lenkiewicz AM, Adamczyk A.
    Academic press:
    PLoS One. (year: 2014, volume: 9(4), pages: e94259), Publisher: Public Library Science
    Status:
    Published
    DOI:
    10.1371/journal.pone.0094259 – link to the publication

Articles in post-conference publications (13)

  1. Parkinson's disease related nitrosative stress affects the expression of Parkin and PC12 cell viability.

    Authors:
    Anna M. Lenkiewicz, Anna Wilkaniec, Agata Adamczyk
    Conference:
    Neurochemical Conference 2013 Emerging topics in neurological diseases: molecular mechanisms, diagnosis and therapy. (year: 2013, pages: 392), Publisher: Termedia/Folia Neurophatol. 2013, 51, 4, 392.
    Date:
    conference Oct. 24-25, 2013,
    Status:
    Published
    DOI:
    link to the publication

  2. Extracellular oligomers of alpha-Synuclein induces Parkin modifications and dopaminergic PC12 cells death

    Authors:
    Anna M. Lenkiewicz, Anna Wilkaniec and Agata Adamczyk
    Conference:
    27th ECNP Congress (year: 2014, pages: P.5.a.007), Publisher: ECNP
    Date:
    conference 18-21.10.2014
    Status:
    Published

  3. Alkaloids from Huperziaselago protect dopaminergic PC12 cells against sodium nitroprusside-evoked oxidative stress, mitochondrial dysfunction and apoptosis..

    Authors:
    •Anna M. Lenkiewicz, Grzegorz A. Czapski, Anna Wilkaniec, Wojciech Szypuła and Agata Adamczyk
    Conference:
    Neurochemical conference 2015 Neuropsychoimmunological mechanisms in the pathology of neurodegenerative diseases. From biomarkers to therapeutics Warsaw, Poland. (year: 2015, pages: p.424,B25.), Publisher: TERMEDIA PUBLISHING HOUSE LTD, Folia Neuropathol. 2015,53,4,p.424,B25.
    Date:
    conference 22-23 October 2015,
    Status:
    Published
    DOI:
    link to the publication

  4. Extracellular alpha-synuclein-evoked parkin deregulation promotes Tau phosphorylation and dopaminergic PC12 cells death.

    Authors:
    Adamczyk A, Lenkiewicz A, Wilkaniec A, Gąssowska M
    Conference:
    The 12th International Congress on Alzheimer's & Parkinson's Diseases Mechanisms, clinical strategies and promising treatments of neurodegenerative diseases Nice, France. (year: 2015, pages: p.1164,ADPD5-1213.), Publisher: Karger, Neurodegener Dis 2015,15 (Suppl 1),352-1969.
    Date:
    conference 18-22 Mar, 2015
    Status:
    Published

  5. S-nitrosylation of Parkin as a novel regulator of extracellular alpha-synuclein evoked dopaminergic cell death

    Authors:
    Anna M. Lenkiewicz1, Anna Wilkaniec1, Kristina Friedland2 and Agata Adamczyk1
    Conference:
    The 12th International Congress on Alzheimer's & Parkinson's Diseases Mechanisms, clinical strategies and promising treatments of neurodegenerative diseases, Nice, France. (year: 2015, pages: 1252), Publisher: Karger, Neurodegener Dis 2015;15:(suppl 1): 352-1969,1252
    Date:
    conference 18-22 Mar, 2015
    Status:
    Published

  6. The involvement of purinergic signaling in mitochondria dysfunction induced by alpha-synuclein.

    Authors:
    Anna M. Lenkiewicz, Anna Wilkaniec, Agata Adamczyk
    Conference:
    12th International Congress of the Polish Neuroscience Society, Gdańsk, Poland (year: 2015, pages: S99,P.14.3), Publisher: Nencki Inst. Experimental Biol.,Acta Neurobiol. Exp.75,2015 Suppl. S99,P.14.3
    Date:
    conference 6-8 Sep. 2015
    Status:
    Published
    DOI:
    link to the publication

  7. Alkaloids of Huperziaselago protect PC12 cells against alpha-synuclein-induced cell damage: involvement of anti-oxidant and anti-apoptotic properties

    Authors:
    Lenkiewicz A, Adamczyk A, Wilkaniec A
    Conference:
    EMBO/EMBL Symposium Mechanisms of neurodegeneration Heidelberg, Germany (year: 2015, pages: p.195,157), Publisher: EMBO/EMBL
    Date:
    conference 14-17 June 2015
    Status:
    Published

  8. Oxidative/nitrosative stress evoked by α-Synuclein oligomers lead to post-translational Parkin modification in PC12 cells.

    Authors:
    Anna M. Lenkiewicz, Anna Wilkaniec and Agata Adamczyk.
    Conference:
    10th Warsaw Intl Medical Congress (year: 2014, pages: 10,2, suppl.1,p.64.91.), Publisher: Arch. Med. Sci
    Date:
    conference 15-18.05.2014
    Status:
    Published

  9. The role of glycogen synthase kinase-3 beta in alpha-synuclein-evoked tau phosphorylation.

    Authors:
    Magdalena Gąssowska, Grzegorz A. Czapski, Agata Adamczyk
    Conference:
    11th International Congress, Polish Neuroscience Society (year: 2013, pages: P6.5), Publisher: Acta Neurobiol.Exp.73,P6.5,Suppl.
    Date:
    conference September 15-17, 2013 , Poznań
    Status:
    Published

  10. The role of purinergic receptors in alpha synuclein mediated mitochondrial dysfunction and dopaminergic cell death.

    Authors:
    Anna Wilkaniec, Grzegorz A. Czapski, Agata Adamczyk
    Conference:
    7th International Symposium on Experimental and Clinical Neurobiology (year: 2013, pages: 117), Publisher: Slovak Academy of Sciences
    Date:
    conference June 23-27,2013 Kosice, Slovakia.
    Status:
    Published

  11. Extracellular α-synuclein and its role in nitrosative stress, mitochondrial dysfunction and neurodegeneration

    Authors:
    Anna Wilkaniec, Agata Adamczyk, Joanna B. Strosznajder.
    Conference:
    Neurochemical Conference 2013 Emerging topics in neurological diseases: molecular mechanisms, diagnosis and therapy. (year: 2013, pages: 379), Publisher: Termedia/Folia Neurophatol. 2013, 51, 4, 379
    Date:
    conference Oct. 24-25, 2013, Warszawa
    Status:
    Published
    DOI:
    link to the publication

  12. Extracellular alpha-synuclein induces calpain-dependent overactivation of Cyclin-dependent kinase 5 in PC12 cells.

    Authors:
    Adamczyk Agata, Gąssowska Magdalena, Wilkaniec Anna, Cieślik Magdalena, Czapski Grzegorz A
    Conference:
    11th International Congress, Polish Neuroscience Society, (year: 2013, pages: P1.1), Publisher: Acta Neurobiol. Exp. 2013,73, P1.1 Suppl
    Date:
    conference September 15-17, 2013 , Poznań
    Status:
    Published

  13. Effect of α-synuclein oligomers on Parkin expression in PC12 cells. Relevance to Parkinson's disease.

    Authors:
    Anna M. Lenkiewicz, Anna Wilkaniec and Agata Adamczyk
    Conference:
    8th Intl Symposium on Neuroprotection Neurorepair (year: 2014, pages: 41643), Publisher: książka abstraktów
    Date:
    conference 8-12.04.2014
    Status:
    Published

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