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The role of polymorphisms and expressions of the receptors from the CD94/NKG2 family and the HLA-E molecule in etiopathogenesis of the rheumatoid arthritis.

2012/05/N/NZ5/02607

Keywords:

CD94/NKG2 HLA-E rheumatoid arthritis

Descriptors:

  • NZ5_1: Etiology of human diseases
  • NZ5_3: Pathogenesis of human diseases

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Instytut Immunologii i Terapii Doświadczalnej im. Ludwika Hirszfelda PAN

woj. dolnośląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Milena Iwaszko 

Number of co-investigators in the project: 2

Call: PRELUDIUM 3 - announced on 2012-03-15

Amount awarded: 149 700 PLN

Project start date (Y-m-d): 2013-02-21

Project end date (Y-m-d): 2016-08-20

Project duration:: 42 months (the same as in the proposal)

Project status: Project settled

Information in the final report

  • Publication in academic press/journals (5)
  • Articles in post-conference publications (7)
  1. Influence of NKG2D genetic variants on response to anti-TNF agents in patients with rheumatoid arthritis.
    Authors:
    Iwaszko M, Świerkot J, Kolossa K, Jeka S, Wiland P, Bogunia-Kubik K
    Academic press:
    Genes (Basel) (rok: 2018, tom: 9, strony: 64), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/genes9020064 - link to the publication
  2. Association of MICA-129Met/Val polymorphism with clinical outcome of anti-TNF therapy and MICA serum levels in patients with rheumatoid arthritis
    Authors:
    Iwaszko M, Świerkot J, Dratwa M, Wysoczańska B, Korman L, Bugaj B, Kolossa K, Jeka S, Wiland P, Bogunia-Kubik K.
    Academic press:
    The Pharmacogenomics Journal (tom: -, strony: -), Wydawca: Nature Publishing Group
    Status:
    Submitted
    DOI:
    brak - link to the publication
  3. Polymorphisms within the human leucocyte antigen-E gene and their associations with susceptibility to rheumatoid arthritis as well as clinical outcome of anti-tumour necrosis factor therapy.
    Authors:
    Iwaszko M, Świerkot J, Kolossa K, Jeka S, Wiland P, Bogunia-Kubik K.
    Academic press:
    Clin Exp Immunol. (rok: 2015, tom: 182, strony: 270-277), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1111/cei.12696. - link to the publication
  4. Significance of association of HLA-C and HLA-E with psoriatic arthritis.
    Authors:
    Sokolik R, Gębura K, Iwaszko M, Świerkot J, Korman L, Wiland P, Bogunia-Kubik K
    Academic press:
    Human Immunology (rok: 2014, tom: 75, strony: 1188–1191), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.005. - link to the publication
  5. Influence of CD94 and NKG2A variants on susceptibility to rheumatoid arthritis and efficacy of anti-TNF treatment.
    Authors:
    Iwaszko M, Świerkot J, Kolossa K, Jeka S, Wiland P, Bogunia-Kubik K.
    Academic press:
    Joint Bone Spine (rok: 2016, tom: 83, strony: 75-79), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10. - link to the publication
  1. Association of the HLA-E and NKG2A genes polymorphisms with rheumatoid arthritis and a response to therapy with TNF inhibitors.
    Authors:
    Iwaszko M., Świerkot J., Nowak B., Białowąs K., Wiland P., Bogunia-Kubik K.
    Conference:
    XV Zjazd Polskiego Towarzystwa Immunologii Klinicznej i Doświadczalnej (rok: 2014, ), Wydawca: Termedia Publishing House
    Data:
    konferencja 26-28.06
    Status:
    Published
  2. Association of the MICA polymorphism with clinical response to anti-TNF therapy in rheumatoid arthritis patients.
    Authors:
    Iwaszko M, Świerkot J, Kolossa K, Jeka S, Wiland P, Bogunia-Kubik K
    Conference:
    31st European Immunogenetics and Histocompatibility Conference (rok: 2017, ), Wydawca: Wiley
    Data:
    konferencja 30.05- 02.06
    Status:
    Published
    DOI:
    link to the publication
  3. HLA-E AND NKG2A GENE POLYMORPHISMS, DISEASE SUSCEPTIBILITY AND RESPONSE TO ANTI-TNF TREATEMENT IN POLISH PATIENTS WITH RHEUMATOID ARTHRITIS
    Authors:
    Iwaszko M, Świerkot J, Nowak B, Białowąs K, Wiland P, Bogunia-Kubik K
    Conference:
    9th International Congress on Autoimmunity (rok: 2014, ), Wydawca: -
    Data:
    konferencja 26-30.03.
    Status:
    Published
  4. HLA-E gene polymorphisms in rheumatoid arthritis and psoriatic arthritis.
    Authors:
    Iwaszko M, Świerkot J, Sokolik R, Nowak B, Gębura K, Korman L, Wiland P, Bogunia-Kubik K
    Conference:
    28th European Immunogenetics and Histocompatibility Conference (rok: 2014, ), Wydawca: Wiley
    Data:
    konferencja 25-28.06.
    Status:
    Published
    DOI:
    link to the publication
  5. Impact of the NKG2D genetic variants on clinical response to anti-TNF therapy in rheumatoid arthritis patients.
    Authors:
    Iwaszko M, Świerkot J, Kolossa K, Jeka S, Wiland P, Bogunia-Kubik K.
    Conference:
    10th East-West Immunogenetics Conference (rok: 2016, ), Wydawca: Springer
    Data:
    konferencja 21-23.04
    Status:
    Published
    DOI:
    link to the publication
  6. TNF-ALPHA, TNF RECEPTOR , HLA-E AND NKG2A GENE POLYMORPHISMS AND RESPONSE TO ANTI-TNF- ALPHA TREATEMENT IN RHEUMATOID ARTHRITIS
    Authors:
    Jerzy Swierkot, Milena Iwaszko, Katarzyna Gebura, Beata Nowak, Lucyna Korman, Katarzyna Kolossa, Slawomir Jeka, Piotr Wiland, Katarzyna Bogunia-Kubik
    Conference:
    European League Against Rheumatism (EULAR) Congress 2014 (rok: 2014, ), Wydawca: BMJ Publishing Group Limited
    Data:
    konferencja 11-14.06
    Status:
    Published
    DOI:
    link to the publication
  7. Association of the HLA-E gene polymorphisms with the efficacy of anti-TNF treatment in female patients with rheumatoid arthritis (RA).
    Authors:
    Milena Iwaszko, Jerzy Świerkot, Katarzyna Kolossa, Sławomir Jeka, Piotr Wiland, Katarzyna Bogunia-Kubik
    Conference:
    29th European Immunogenetics and Histocompatibility Conference (rok: 2015, ), Wydawca: Wiley
    Data:
    konferencja 26-29.04
    Status:
    Published
    DOI:
    link to the publication

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