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Information of the project and the call

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Studies on the desulfuration of 2-thiouridines in relation to tRNA damage in oxidative stress conditions

2011/03/B/ST5/02669

Keywords:

2-thiouridine desulfuration tRNA oxidative stress tRNA damage in oxidative stress

Descriptors:

  • ST5_16:
  • ST5_23:

Panel:

ST5 - Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering

Host institution :

Centrum Badań Molekularnych i Makromolekularnych PAN

woj. łódzkie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Barbara Nawrot 

Number of co-investigators in the project: 10

Call: OPUS 2 - announced on 2011-09-15

Amount awarded: 842 100 PLN

Project start date (Y-m-d): 2012-09-05

Project end date (Y-m-d): 2015-09-04

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Pompa olejowa.
  2. Pompa próżniowa (8 000 PLN)
  3. Miernik ph (4 000 PLN)
  4. SciFinder (5 000 PLN)
  5. Wirówka do odparowań (15 000 PLN)
  6. Wyparka rotacyjna (15 000 PLN)
  7. Zestaw HPLC (240 000 PLN)

Information in the final report

  • Publication in academic press/journals (7)
  • Articles in post-conference publications (2)
  1. An efficient approach for conversion of 5-substituted 2-thiouridines built in RNA oligomers into corresponding desulfured 4-pyrimidinone products
    Authors:
    Anna Chwialkowska, Ewelina Wielgus, Grazyna Leszczynska, Milena Sobczak, Barbara Mikolajczyk, Elzbieta Sochacka, Barbara Nawrot
    Academic press:
    Bioorganic & Medicinal Chemistry Letters (rok: 2015, tom: 25, strony: 3100-3104), Wydawca: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.bmcl.2015.06.019. - link to the publication
  2. Guanosine in a single stranded region of anticodon stem-loop tRNA models is prone to oxidative damage resulting in dehydroguanidinohydantoin and spiroiminodihydantoin lesions
    Authors:
    Agnieszka Tomaszewska-Antczak, Piotr Guga, Barbara Nawrot, Geneviève Pratviel
    Academic press:
    Chemistry - A European Journal (rok: 2015, tom: 21, strony: 6381-5.), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/chem.201406409 - link to the publication
  3. Desulfuration of 2-thiouridine with hydrogen peroxide in the physiological pH range 6.6-7.6 is pH-dependent and results in two distinct products
    Authors:
    E. Sochacka, P. Bartos , K. Kraszewska, B. Nawrot
    Academic press:
    Bioorg. Med. Chem. Lett. (rok: 2013, tom: 23, strony: 5803-5805), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bmcl.2013.08.114. - link to the publication
  4. The influence of the C5 substituent on the 2-thiouridine desulfuration pathway and the conformational analysis of the resulting 4-pyrimidinone products
    Authors:
    Bartos P, Ebenryter-Olbinska K, Sochacka E, Nawrot B.
    Academic press:
    Bioorg Med Chem (rok: 2015, tom: 23, strony: 5587-94), Wydawca: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.bmc.2015.07.030 - link to the publication
  5. Nucleoside modifications in the regulation of gene expression: focus on tRNA
    Authors:
    Markus Duechler, Grazyna Leszczynska, Elzbieta Sochacka, Barbara Nawrot
    Academic press:
    Cellular and Molecular Life Sciences (CMLS) , Wydawca: SPRINGER
    Status:
    Submitted
    DOI:
    CMLS-S-15-01191 - link to the publication
  6. Transformation of a wobble 2-thiouridine to 2-selenouridine via S-geranyl-2-thiouridine as a possible cellular pathway
    Authors:
    Paulina Bartos, Anna Maciaszek, Anna Rosinska, Elzbieta Sochacka, Barbara Nawrot
    Academic press:
    Bioorganic Chemistry (rok: 2014, tom: 56, strony: 49-53), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bioorg.2014.05.012 - link to the publication
  7. 2-Thiouracil deprived of thiocarbonyl function preferentially base pairs with guanine rather than adenine in RNA and DNA duplexes
    Authors:
    E. Sochacka, R. H. Szczepanowski, M. Cypryk, M. Sobczak, M. Janicka, K. Kraszewska, P. Bartos, A. Chwialkowska, B. Nawrot
    Academic press:
    Nucleic Acids Research (rok: 2015, tom: 43, strony: 2499-2512), Wydawca: Oxford Journals
    Status:
    Published
    DOI:
    10.1093/nar/gkv109 - link to the publication
  1. The possible pathway of oxone-mediated desulfuration of 2-thiouridine
    Authors:
    Paulina Bartos L. Piotrowski, B. Nawrot, G. Pratviel, E. Sochacka
    Conference:
    XVI Symposium on Chemistry on Nucleic Acid Components, Cesky Krumlov, (rok: 2014, ), Wydawca: Institute of Organic Chemsitry and Biochemistry, Academy of Sciences of the Czech Republic
    Data:
    konferencja 8-13.06.2014
    Status:
    Published
  2. CHEMICAL TRANSFORMATION OF 2-THIOURIDINE INTO 2-SELENO-URIDINE VIA NEWLY DISCOVERED S-GERANYL-2-THIOURIDINE
    Authors:
    Anna ROSINSKA, Anna MACIASZEK, Paulina BARTOS, Elzbieta SOCHACKA, Barbara NAWROT
    Conference:
    XVI Symposium on Chemistry on Nucleic Acid Components, Cesky Krumlov, (rok: 2014, ), Wydawca: Institute of organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic
    Data:
    konferencja 8-13.06.2014
    Status:
    Published

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