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Identification of breast cancer cells death and senescence mechanisms induction resulting from telomerase silencing with the use of lentiviral system.

2011/03/B/NZ7/00512

Keywords

Descriptors

  • NZ7_14: Farmacja, farmakoterapia, farmakologia
  • NZ1_1: Biologia molekularna
  • NZ3_1: Biologia komórki

Panel

NZ7 – Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu, Wydział Farmaceutyczny

Voivodeship: wielkopolskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr hab. Błażej Rubiś

Number of co-investigators in the project: 5

Call

OPUS 2 – announced on 2011-09-15

Amount awarded
400 000 PLN
Project start date
2012-08-22
Project end date
2016-02-21
Project duration
42 months (the same as in the proposal)
Project status
Project settled

Equipment purchased [PL]

  1. Licencja PPT Drawing Toolkits Bundle- Biology.
  2. Zestaw do obserwacji we fluorescencji do mikroskopu.
  3. aparat do przeprowadzania analizy Westen Blot. Cost: 5 000 PLN
  4. doposazenie mikroskopu.
  5. komputer z systemem antyprzepieciowym. Cost: 9 000 PLN
  6. waga analityczna. Cost: 12 000 PLN
  7. wirówka laboratoryjna. Cost: 17 000 PLN
  8. zamrażarka. Cost: 4 000 PLN
  9. łaźnia wodna. Cost: 4 000 PLN

Information in the final report

Publication in academic press/journals (9)

  1. Telomeraza jako cel terapii przeciwnowotworowej

    Authors:
    Marta Kowalska, Natalia Lipińska, Aleksandra Romaniuk, Błażej Rubiś
    Academic press:
    Journal of Laboratory Diagnostics (year: 2014, volume: 50, pages: 159-167), Publisher: Diagn Lab
    Status:
    Published
    DOI:
    link to the publication

  2. Telomerase as a useful target in cancer fighting-the breast cancer case.

    Authors:
    Holysz H, Lipinska N, Paszel-Jaworska A, Rubis B.
    Academic press:
    Tumour Biol. (year: 2013, volume: 34, pages: 1371-1380), Publisher: Springer
    Status:
    Published
    DOI:
    10.1007/s13277-013-0757-4 – link to the publication

  3. Telomerase modulation in therapeutic approach

    Authors:
    Romaniuk A, Kopczynski P, Ksiazek K, Rubis B.
    Academic press:
    Current Pharmaceutical Design (year: 2014, volume: 20, pages: 6438-6451), Publisher: Bentham Science
    Status:
    Published
    DOI:
    link to the publication

  4. Doksorubicyna - nowe oblicze starego leku

    Authors:
    Natalia Lipińska, Przemysław Kopczyński, Hanna Hołysz, Błażej Rubiś
    Academic press:
    Postepy Biologii Komórki (year: 2013, volume: 40, pages: 633-644), Publisher: Polskie Towarzystwo Anatomiczne, Polskie Towarzystwo Biologii Komórki, Fundacja Biologii Komórki i Biologii Molekularnej
    Status:
    Published

  5. Telomere length assessment in leukocytes presents potential diagnostic value in patients with breast cancer.

    Authors:
    Barczak W, Rozwadowska N, Romaniuk A, Lipińska N, Lisiak N, Grodecka-Gazdecka S, Książek K, Rubiś B.
    Academic press:
    Oncology Letters (year: 2016, volume: 11, pages: 2305-2309), Publisher: Spandidos
    Status:
    Published
    DOI:
    10.3892/ol.2016.4188 – link to the publication

  6. Telomerase and drug resistance in cancer

    Authors:
    Natalia Lipinska, Aleksandra Romaniuk, Anna Paszel-Jaworska, Ewa Toton, Przemyslaw Kopczynski, Blazej Rubis
    Academic press:
    Cellular and Molecular Life Sciences (year: 2017, volume: w trakcie, pages: w trakcie paginacji), Publisher: Springer
    Status:
    Published
    DOI:
    10.1007/s00018-017-2573-2 – link to the publication

  7. Telomerase as a target in diagnosis and treatment of cancer in postmenopausal women

    Authors:
    Natalia Lipińska, Błażej Rubiś
    Academic press:
    Menopause Review (year: 2013, volume: 17, pages: 478-483), Publisher: terMedia
    Status:
    Published
    DOI:
    10.5114/pm.2013.39812 – link to the publication

  8. Telomerase downregulation induces proapoptotic genes expression and initializes breast cancer cells apoptosis followed by DNA fragmentation in a cell type dependent manner.

    Authors:
    Rubis B, Holysz H, Gladych M, Toton E, Paszel A, Lisiak N, Kaczmarek M, Hofmann J, Rybczynska M.
    Academic press:
    Mol Biol Rep. (year: 2013, volume: 40, pages: 4995-5004), Publisher: Springer
    Status:
    Published
    DOI:
    10.1007/s11033-013-2600-9 – link to the publication

  9. Telomere Shortening in Down Syndrome Patients— When Does It Start?

    Authors:
    Aleksandra Gruszecka, Przemys1aw Kopczynski, Dorota Cudzilo, Natalia Lipinska, Aleksandra Romaniuk, Wojciech Barczak, Natalia Rozwadowska, Ewa Toton and Blazej Rubis
    Status:
    Accepted for publication

Articles in post-conference publications (8)

  1. Telomerase inhibition provokes broad spectrum of morphological and physiological changes in cancer cells.

    Authors:
    Hanna Hołysz, Aleksandra Romaniuk, Anita Lipińska, Błażej Rubiś
    Conference:
    48th Congress of the Polish Biochemical Society (year: 2013, pages: 92), Publisher: Acta Bioch. Pol.
    Date:
    conference Wrzesień 2-5
    Status:
    Published
    DOI:
    link to the publication

  2. Telomerase inhibition leads to death of breast cancer cells and increases sensitivity to doxorubicin.

    Authors:
    Romaniuk Aleksandra, Lipińska Natalia, Rubiś Błażej
    Conference:
    EMBO Young Scientists Forum. Warsaw, Poland, 2-3 July 2015. Book of Abstracts. (year: 2015, pages: 170), Publisher: EMBO
    Date:
    conference 2-3 lipca 2015
    Status:
    Published
    DOI:
    link to the publication

  3. Telomeraza - nowy molekularny punkt uchwytu leków przeciwnowotworowych

    Authors:
    Aleksandra Romaniuk, Natalia Lipińska, Marta Gładych, Błażej Rubiś
    Conference:
    XXII Naukowy Zjazd Polskiego Towarzystwa Farmaceutycznego Farmacja - Nauka - Społeczeństwo. (year: 2013, pages: 83), Publisher: B. m., 2013
    Date:
    conference 18-21 IX
    Status:
    Published

  4. Anticancer mechanisms of TMPyP4 in breast cancer cell lines MCF7 and MDA-MB-231

    Authors:
    Lipinska N, Holysz H, Romaniuk A, Kaczmarek M, Rubis B
    Conference:
    Telomere, Telomerase and Disease (year: 2014, pages: 701-702), Publisher: EMBO
    Date:
    conference 30.04 – 04.05
    Status:
    Published
    DOI:
    link to the publication

  5. G-Quadruplex as a target for drug design

    Authors:
    A. Głuszyńska, E. Rajczak, B. Rubiś, B. Juskowiak
    Conference:
    XXI International Round Table of Nucleosides, Nucleotides and Nucleic Acids (year: 2014, pages: 108), Publisher: bokiz.pl
    Date:
    conference 24-28.08.2014
    Status:
    Published

  6. Interaction of new carbazole ligand containing imidazole moiety with different forms of nucleic acids - spectroscopic study and bioactivity

    Authors:
    A. Głuszyńska, A. Kowal, B. Juskowiak, B. Rubiś, N. Lipińska, M. Rybczyńska
    Conference:
    5th International Meeting on G-Quadruplex Nucleic Acids, Bordeaux (year: 2015, pages: 1), Publisher: http://www.u-bordeaux.fr/
    Date:
    conference 26-28.05.2015
    Status:
    Published
    DOI:
    link to the publication

  7. Wpływ inhibitora telomerazy TMPyP4 na procesy adhezji i migracji w komórkach raka piersi MCF7 i MDA-MB-231

    Authors:
    Lipińska N, Romaniuk A, Rubiś B.
    Conference:
    I Ogólnopolska Konferencja Studentów Medycyny Laboratoryjnej Młodzi Diagności w Łodzi (year: 2014, pages: 20), Publisher: Łódzki Uniwersytet Medyczny
    Date:
    conference 15,11
    Status:
    Published

  8. Mechanizmy działania inhibitorów telomerazy, a ich potencjalne wykorzystanie w terapii raka piersi

    Authors:
    Lipińska N, Romaniuk A, Hołysz H, Rubiś B
    Conference:
    V Wykłady Otwarte z cyklu Spotkania Młodych z Nauką w Poznaniu (year: 2014, pages: 42), Publisher: Uniwersytet Medyczny w Poznaniu
    Date:
    conference 12,04
    Status:
    Published

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