Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

Delete all

Host immune response to respiratory virus infections associated with asthma exacerbations - role for parainfluenza virus.

2011/02/A/NZ5/00341

Keywords:

bronchial asthma asthma exacerbations respiratory virus infection immune response to virus infection parainfluenza virus microRNA

Descriptors:

  • NZ5_3: Pathogenesis of human diseases

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Uniwersytet Medyczny w Łodzi, Wydział Lekarski

woj. łódzkie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Marek Kowalski 

Number of co-investigators in the project: 13

Call: MAESTRO 1 - announced on 2011-06-15

Amount awarded: 2 710 000 PLN

Project start date (Y-m-d): 2012-05-11

Project end date (Y-m-d): 2017-05-11

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Izolator DNA (50 000 PLN)
  2. Maszyna do lodu (21 000 PLN)
  3. Odwrócony mikroskop z fluorescencją (150 000 PLN)
  4. Aparat do pomiaru poziomu tlenku azotu w powietrzu wydychanym.
  5. Luminex system (190 000 PLN)
  6. Ultrawirówka (10 000 PLN)
  7. Szafa laminarna.
  8. Cieplarka z CO2 (53 000 PLN)
  9. Drobny sprzęt laboratoryjny ( pipety automatyczne).
  10. System do monitorowania wzrostu komórek w czasie rzeczywistym.
  11. Amplifikator PCR (53 000 PLN)
  12. EBC Collector (TurboDecs09) (51 000 PLN)
  13. Zamrażarka - 75 0C.

Information in the final report

  • Publication in academic press/journals (10)
  1. Human parainfluenza virus type 3 (HPIV3) induces production of RANTES and IFNgamma in human nasal epithelial cells (HNECs)
    Authors:
    A. Lewandowska-Polak,M. Brauncajs, E. Paradowska, M. Jarzębska, M. Kurowski, S. Moskwa, Z.J. Leśnikowski, M.L. Kowalski
    Academic press:
    Journal of Inflammation (rok: 2015, tom: 12, strony: 45298), Wydawca: BioMed Central Ltd
    Status:
    Published
    DOI:
    10.1186/s12950-015-0054-7 - link to the publication
  2. Impaired virus replication and decreased innate immune responses to viral infections in nasal epithelial cells from patients with allergic rhinitis
    Authors:
    Głobińska A., Pawełczyk M., Piechota-Polańczyk A., Olszewska-Ziąber A., Moskwa S., Mikołajczyk A., Jabłońska A., Brauncajs M., Jarzębska M., Taka S, Papadopoulos N.G., Kowalski M.L.
    Academic press:
    Clinical and Experimental Immunology (rok: 2017, tom: 187, strony: 100-112), Wydawca: SPRINGER-VERLAG ITALIA SRL
    Status:
    Published
    DOI:
    10.1111/cei.12869 - link to the publication
  3. The role of human parainfluenza virus infections in the immunopathology of the respiratory tract
    Authors:
    Pawełczyk Malgorzata, Kowalski Marek Leszek
    Academic press:
    Current Allergy Asthma Reports (rok: 2017, tom: 17, strony: 45301), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s11882-017-0685-2 - link to the publication
  4. Cytomegalovirus DNA is highly prevalent in the blood of patients with asthma and is associated with age and asthma traits
    Authors:
    Kowalski ML, Wardzynska A, Studzinska M, Pawelczyk M, Lesnikowski ZJ, Paradowska E
    Academic press:
    Allergy (rok: 2017, tom: 72, strony: 2035-2038), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1111/all.13233 - link to the publication
  5. Circulating microRNAs and T-cells cytokine expression are associated with characteristics of asthma exacerbation
    Authors:
    Wardzyńska A, Pawełczyk M, Rywaniak J, Kurowski M, Makowska JS, Kowalski ML
    Academic press:
    Allergy, Asthma and Immunology Research (rok: 2019, tom: -, strony: -), Wydawca: Korean Academy of Asthma, Allergy and Clinical Immunology
    Status:
    Submitted
    DOI:
    - - link to the publication
  6. MicroRNAs and the immune response to respiratory virus infections
    Authors:
    Anna Głobińska, Małgorzata Pawełczyk, Marek L. Kowalski
    Academic press:
    Expert Review of Clinical Immunology (rok: 2014, tom: 10, strony: 963-971), Wydawca: Expert Review Ltd
    Status:
    Published
    DOI:
    10.1586/1744666X.2014.913482 - link to the publication
  7. Innate immune response to viral infections in primary bronchial epithelial cells is modified by atopic status of asthma patients.
    Authors:
    Sylwia Moskwa, Wojciech Piotrowski, Jerzy Marczak, Małgorzata Pawełczyk, Anna Lewandowska-Polak, Marzanna Jarzębska, Małgorzata Brauncajs, Anna Głobińska, Paweł Górski, Nikolaos G. Papadopoulos, Michael R. Edwards, Sebastian L. Johnston, Marek L. Kowalski
    Academic press:
    Allergy, Asthma and Immunology Research (rok: 2018, tom: 10, strony: 144-154), Wydawca: The Korean Academy of Asthma, Allergy and Clinical Immunology • The Korean Academy of Pediatric Allergy and Respiratory Disease
    Status:
    Published
    DOI:
    10.2.144. - link to the publication
  8. Parainfluenza virus infection enhances NSAIDs-induced inhibition of PGE2 generation and COX-2 expression in human airway epithelial cells.
    Authors:
    Anna Lewandowska-Polak, Małgorzata Brauncajs, Marzanna Jarzębska, Małgorzata Pawełczyk, Marcin Kurowski, Joanna Makowska, Marek L. Kowalski
    Academic press:
    Advances in Medical Sciences (rok: 2019, tom: 64, strony: 338-343), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.advms.2019.04.004. - link to the publication
  9. Periostin in Exhaled Breath Condensate and in Serum of Asthmatic Patients: Relationship to Upper and Lower Airway Disease
    Authors:
    Aleksandra Wardzyńska, Joanna S. Makowska, Małgorzata Pawełczyk, Aleksandra Piechota-Polańczyk, Marcin Kurowski, Marek L. Kowalski
    Academic press:
    Allergy, Asthma and Immunology Research (rok: 2017, tom: 9, strony: 126-132), Wydawca: The Korean Academy of Asthma, Allergy and Clinical Immunology • The Korean Academy of Pediatric Allergy and Respiratory Disease
    Status:
    Published
    DOI:
    10.4168/aair.2017.9.2.126 - link to the publication
  10. Zakażenie wirusem paragrypy typu 3 (PIV-3) pierwotnych komórek nabłonka oskrzeli hodowanych in vitro jako model doświadczalny zaostrzenia astmy oskrzelowej.
    Authors:
    Moskwa S., Piotrowski W., Marczak J., Lewandowska-Polak A., Jarzębska M., Brauncajs M., Globinska A., Piechota-Polańczyk A., Górski P., Kowalski M.L.
    Academic press:
    Alergia, Astma, Immunologia (rok: 2015, tom: 20, strony: 264-268), Wydawca: Mediton
    Status:
    Published
    DOI:
    brak - link to the publication

O Narodowym Centrum Nauki

Finansowanie nauki

Współpraca zagraniczna

Centrum prasowe

Deklaracja dostępności
Przetwarzanie danych osobowych
Polityka cookies

Partnerzy