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Information on the principal investigator and host institution

Information of the project and the call

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Impact of endocrine disrupting chemicals - 4,para nonylphenol - on toxic effects mediated by xenobiotic receptors PXR and CAR during neurodevelopment in vitro and in vivo.

2011/01/N/NZ4/04950

Keywords:

endocrine disrupters EDCs neurogenesis neurodevelopment xenoestrogen xenobiotic receptors PXR CAR estrogen receptors ER.

Descriptors:

  • NZ4_8: Neuroendocrinology
  • NZ4_6: Endocrinology
  • NZ3_3: Apoptosis

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Instytut Farmakologii Polskiej Akademii Nauk

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Ewa Litwa 

Number of co-investigators in the project: 3

Call: PRELUDIUM 1 - announced on 2011-03-15

Amount awarded: 235 560 PLN

Project start date (Y-m-d): 2011-12-15

Project end date (Y-m-d): 2014-12-14

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Information in the final report

  • Publication in academic press/journals (5)
  • Articles in post-conference publications (3)
  1. Classical estrogen receptor signaling is not involved in apoptotic actions of nonylphenol in mouse embryonic neuronal cells
    Authors:
    Ewa Litwa, Joanna Rzemieniec, Agnieszka Wnuk, Malgorzata Kajta
    Academic press:
    Folia Neuropathologica (rok: 2013, tom: 51 (4), strony: 392), Wydawca: Polish Association of Neuropathologists and M. Mossakowski Medical Research Centre of the Polish Academy of Sciences/ Termedia
    Status:
    Published
    DOI:
    10.5114/fn.2013.39820 - link to the publication
  2. Prenatal exposure to 4-para-nonylphenol disrupts estrogen receptor α but not estrogen receptor β and retinoid X receptor signaling in mouse embryonic neuronal cells.
    Authors:
    Litwa E., Rzemieniec J., Wnuk A., Lason W., Kajta M.
    Academic press:
    Folia Neuropathologica (rok: 2014, tom: 52 (3), strony: 344), Wydawca: Polish Association of Neuropathologists and M. Mossakowski Medical Research Centre of the Polish Academy of Sciences/ Termedia
    Status:
    Published
    DOI:
    10.5114/fn.2014.45656 - link to the publication
  3. RXRα, PXR and CAR xenobiotic receptors mediate the apoptotic and neurotoxic actions of nonylphenol in mouse hippocampal cells
    Authors:
    Litwa E., Rzemieniec J., Wnuk A., Lason W., Krzeptowski W., Kajta M.
    Academic press:
    J Steroid Biochem Mol Biol (rok: 2016, tom: 156, strony: 43-52), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jsbmb.2015.11.018. - link to the publication
  4. Apoptotic and neurotoxic actions of 4-para-nonylphenol are accompanied by activation of retinoid X receptor and impairment of classical estrogen receptor signaling
    Authors:
    Litwa E*, Rzemieniec J*, Lason W*, Krzeptowski W$, Kajta M*
    Academic press:
    The Journal of Steroid Biochemistry and Molecular Biology (rok: 2014, tom: 144, strony: 334-347), Wydawca: Elservier
    Status:
    Published
    DOI:
    10.1016/j.jsbmb.2014.07.014. - link to the publication
  5. Behavioral effects of prenatal exposure to 4-para nonylphenol: studies on female and male mice subjected to the Novel Object Recognition Test
    Authors:
    Malgorzata Kajta, Wladyslaw Lason, Ewa Litwa, Joanna Rzemieniec - autor prezentujący Ewa Litwa
    Academic press:
    International Journal of Psychiatry in Clinical Practice (rok: 2012, tom: 16/ S1, strony: P49), Wydawca: informa health care
    Status:
    Published
    DOI:
    10.3109/2F13651501.2012.736163 - link to the publication
  1. Neurodevelopmental effects of nonylphenol
    Authors:
    Litwa E., Rzemieniec J., Wnuk A., Lasoń W., Kajta M.
    Conference:
    XIX International Congress of the Polish Pharmacological Society (rok: 2015, ), Wydawca: Elsevier, Pharmacol. Rep., 2015, 67, Suppl. 1
    Data:
    konferencja 17–19. IX
    Status:
    Published
    DOI:
    link to the publication
  2. Xenobiotic receptors RXR, PXR and CAR mediate neurotoxic effects of 4-para nonylphenol in mouse brain tissue.
    Authors:
    LITWA E., Rzemieniec J., Wnuk A., Kajta M.:
    Conference:
    9th FENS Forum of Neuroscience, Milan, Italy (rok: 2014, ), Wydawca: FENS
    Data:
    konferencja 05-09 lipca
    Status:
    Published
    DOI:
    link to the publication
  3. Pro-apoptotic and toxic effects of 4-para nonylphenol in mouse embryonic neuronal cells: a role of estrogen and retinoid receptor
    Authors:
    Litwa E., Rzemieniec., Lason W., Kajta M.
    Conference:
    7th International Meeting STEROIDS ANS NERVOUS SYSTEM (rok: 2013, ), Wydawca: Neuroscience Institute Cavalieri Ottelenghi
    Data:
    konferencja 16-20 luty
    Status:
    Published

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