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Impact of endocrine disrupting chemicals - 4,para nonylphenol - on toxic effects mediated by xenobiotic receptors PXR and CAR during neurodevelopment in vitro and in vivo.

2011/01/N/NZ4/04950

Keywords

Descriptors

  • NZ4_8: Neuroendokrynologia
  • NZ4_6: Endokrynologia eksperymentalna
  • NZ3_3: Apoptoza

Panel

NZ4 – Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution

Instytut Farmakologii PAN

Voivodeship: małopolskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

Ewa Joanna Litwa

Number of co-investigators in the project: 3

Call

PRELUDIUM 1 – announced on 2011-03-15

Amount awarded
235 560 PLN
Project start date
2011-12-15
Project end date
2014-12-14
Project duration
36 months (the same as in the proposal)
Project status
Project settled

Information in the final report

Publication in academic press/journals (5)

  1. Behavioral effects of prenatal exposure to 4-para nonylphenol: studies on female and male mice subjected to the Novel Object Recognition Test

    Authors:
    Malgorzata Kajta, Wladyslaw Lason, Ewa Litwa, Joanna Rzemieniec - autor prezentujący Ewa Litwa
    Academic press:
    International Journal of Psychiatry in Clinical Practice (year: 2012, volume: 16/ S1, pages: P49), Publisher: informa health care
    Status:
    Published
    DOI:
    10.3109/2F13651501.2012.736163 – link to the publication

  2. Apoptotic and neurotoxic actions of 4-para-nonylphenol are accompanied by activation of retinoid X receptor and impairment of classical estrogen receptor signaling

    Authors:
    Litwa E*, Rzemieniec J*, Lason W*, Krzeptowski W$, Kajta M*
    Academic press:
    The Journal of Steroid Biochemistry and Molecular Biology (year: 2014, volume: 144, pages: 334-347), Publisher: Elservier
    Status:
    Published
    DOI:
    10.1016/j.jsbmb.2014.07.014. – link to the publication

  3. Prenatal exposure to 4-para-nonylphenol disrupts estrogen receptor α but not estrogen receptor β and retinoid X receptor signaling in mouse embryonic neuronal cells.

    Authors:
    Litwa E., Rzemieniec J., Wnuk A., Lason W., Kajta M.
    Academic press:
    Folia Neuropathologica (year: 2014, volume: 52 (3), pages: 344), Publisher: Polish Association of Neuropathologists and M. Mossakowski Medical Research Centre of the Polish Academy of Sciences/ Termedia
    Status:
    Published
    DOI:
    10.5114/fn.2014.45656 – link to the publication

  4. Classical estrogen receptor signaling is not involved in apoptotic actions of nonylphenol in mouse embryonic neuronal cells

    Authors:
    Ewa Litwa, Joanna Rzemieniec, Agnieszka Wnuk, Malgorzata Kajta
    Academic press:
    Folia Neuropathologica (year: 2013, volume: 51 (4), pages: 392), Publisher: Polish Association of Neuropathologists and M. Mossakowski Medical Research Centre of the Polish Academy of Sciences/ Termedia
    Status:
    Published
    DOI:
    10.5114/fn.2013.39820 – link to the publication

  5. RXRα, PXR and CAR xenobiotic receptors mediate the apoptotic and neurotoxic actions of nonylphenol in mouse hippocampal cells

    Authors:
    Litwa E., Rzemieniec J., Wnuk A., Lason W., Krzeptowski W., Kajta M.
    Academic press:
    J Steroid Biochem Mol Biol (year: 2016, volume: 156, pages: 43-52), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jsbmb.2015.11.018. – link to the publication

Articles in post-conference publications (3)

  1. Neurodevelopmental effects of nonylphenol

    Authors:
    Litwa E., Rzemieniec J., Wnuk A., Lasoń W., Kajta M.
    Conference:
    XIX International Congress of the Polish Pharmacological Society (year: 2015, pages: 9–10), Publisher: Elsevier, Pharmacol. Rep., 2015, 67, Suppl. 1
    Date:
    conference 17–19. IX
    Status:
    Published
    DOI:
    link to the publication

  2. Xenobiotic receptors RXR, PXR and CAR mediate neurotoxic effects of 4-para nonylphenol in mouse brain tissue.

    Authors:
    LITWA E., Rzemieniec J., Wnuk A., Kajta M.:
    Conference:
    9th FENS Forum of Neuroscience, Milan, Italy (year: 2014, pages: C 126, book of abstracts), Publisher: FENS
    Date:
    conference 05-09 lipca
    Status:
    Published
    DOI:
    link to the publication

  3. Pro-apoptotic and toxic effects of 4-para nonylphenol in mouse embryonic neuronal cells: a role of estrogen and retinoid receptor

    Authors:
    Litwa E., Rzemieniec., Lason W., Kajta M.
    Conference:
    7th International Meeting STEROIDS ANS NERVOUS SYSTEM (year: 2013, pages: str. 172), Publisher: Neuroscience Institute Cavalieri Ottelenghi
    Date:
    conference 16-20 luty
    Status:
    Published

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Graphic design and implementation: Jakub Piotrowski