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Information of the project and the call

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Effect of various types of acute exercise and exercise trening on NO/sGC/cGMP pathway and death of dopaminergic neurons in an animal model of Parkinson's disease

2011/01/B/NZ5/01397

Keywords:

endurance training exercise animals model of Parkinson's disease isoforms of NOS cGMP concentration dopamine and its metabolites concentration dopaminergic neurons death

Descriptors:

  • NZ5_9: Other related subjects
  • NZ5_7: Human disease treatment
  • NZ5_3: Pathogenesis of human diseases

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Małgorzata Chalimoniuk 

Number of co-investigators in the project: 5

Call: OPUS 1 - announced on 2011-03-15

Amount awarded: 300 000 PLN

Project start date (Y-m-d): 2011-12-01

Project end date (Y-m-d): 2014-05-31

Project duration:: 30 months (the same as in the proposal)

Project status: Project settled

Information in the final report

  • Publication in academic press/journals (2)
  • Articles in post-conference publications (6)
  1. Endurence training upregulates the nitric oxide/soluble guanylyl cyclase/cyclic guanosine 3' 5'-monophosphate pathway in the striatum, midbrain and cerebellum of male rats
    Authors:
    Chalimoniuk M., Chrapusta S.J., Lukacova N., Langfort J.,
    Academic press:
    Brain Research (rok: 2015, tom: 1618, strony: 29-40), Wydawca: ELSEVIR
    Status:
    Published
    DOI:
    10.1016/j.brainres.2015.05.020. - link to the publication
  2. Diversity of endurance training effects on antioxidant system and oxidative damage in different brain regions of adolescent rats
    Authors:
    Chalimoniuk M., Jagsz S., Sadowska-Krepa E., Chrapusta S.J., Kłapcinska B., Langfort J.,
    Academic press:
    Journal of Physiology and Pharmacology (rok: 2015, tom: 66, strony: 539-547), Wydawca: POLISH PHYSIOLOGICAL SOC, JAGIELLONIAN UNIV SCHOOL MED, INST PHYSIOLOGY, 31-531 KRAKOW, 16 GRZEGORZECKA, POLAND
    Status:
    Published
    DOI:
    brak - link to the publication
  1. Wpływ trening wytrzymałościowy na syntezę i metabolizm dopaminy w systemie nigrostriatalnym w doświadczalnym modelu parkinsonizmu
    Authors:
    Chalimoniuk M., Kania D., Langfort J.,
    Conference:
    IX Dni Fizjoterapii pt." postępy w rehabilitacji –od badań naukowych do praktyki klinicznej (rok: 2015, ), Wydawca: Akademia Wychowania Fizycznego we Wrocławiu
    Data:
    konferencja 12-13 czerwiec
    Status:
    Published
  2. Endurance training counteracts MPTP treatment-related changes in midbrain contents of dopamine and dopamine metabolites, and in parvalbumin expression
    Authors:
    Langfort J, Chalimoniuk M, Kania D, Lukacova N, Chrapusta SJ
    Conference:
    The XX World Congress on Parkinson's Disease and Related Disorders (rok: 2013, ), Wydawca: XX World Congress on Parkinson's Disease and Related Disorders
    Data:
    konferencja 8-11 December, 2013
    Status:
    Published
  3. Endurance training differently affects the activity of the NOS/GC/cGMP pathway in the nigrostriatal system in healthy and 'parkinsonian' (MPTP-treated) Wistar rats
    Authors:
    Chalimoniuk M, Lukacova N, Chrapusta SJ, Langfort J
    Conference:
    The XX World Congress on Parkinson's Disease and Related Disorders (rok: 2013, ), Wydawca: XX World Congress on Parkinson's Disease and Related Disorders
    Data:
    konferencja 8-11 December, 2013
    Status:
    Published
  4. Expression and activity of human type IIA secretory phospholipoase A2 in serum patients with idiopathic parkinsopn's disease
    Authors:
    Cieslik M., Brodacki B., Langfort J., Stepien A., Chalimoniuk M
    Conference:
    Fourth European Workshop on Lipid Mediators, Pasteur Institute, September 27-28, 2012 Paris, France. (rok: 2012, ), Wydawca: Pasteur Institute
    Data:
    konferencja September 27-28, 2012
    Status:
    Published
  5. Endurance training enhances the activity of the NOS/GC/cGMP pathway in the striatum, midbrain and cerebellum in healthy young adult rats
    Authors:
    Małgorzata Chalimoniuk, Nadezda Lukacova, Stanisław Chrapusta, Józef Langfort
    Conference:
    7th International Symposium on Experimental and Clinical Neurobiology (rok: 2013, ), Wydawca: Institute of Neurobiology, Slovak Academy of Sciences
    Data:
    konferencja June 23-27,2013
    Status:
    Published
  6. Testosterone supplementation does not normalize the activity of the striatal nitric oxide synthase/guanylyl cyclase/cGMP pathway in a rat model of Parkinson's disease (PD)
    Authors:
    Chrapusta SJ, Wesołowska-Waliszewska J, Brodacki B, Stępień A, Langfort J, Chalimoniuk M
    Conference:
    The XX World Congress on Parkinson's Disease and Related Disorders (rok: 2013, ), Wydawca: XX World Congress on Parkinson's Disease and Related Disorders
    Data:
    konferencja 8-11 December, 2013
    Status:
    Published

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