Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Linking stress response with genomic instability in chronic myeloid leukaemia cells; role of the PERK-eIF2α phosphorylation pathway in the regulation of BRCA1 translation, mitosis and disease progression.

2011/01/B/NZ3/02145

Keywords:

CML BCR-ABL BRCA1 ER stress PERK eIF2alpha genomic instability mitosis translation

Descriptors:

  • NZ3_7: Signal transduction
  • NZ3_1: Cell biology
  • NZ3_3: Apoptosis

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Instytut Biologii Doświadczalnej im. M. Nenckiego PAN

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Katarzyna Piwocka 

Number of co-investigators in the project: 7

Call: OPUS 1 - announced on 2011-03-15

Amount awarded: 862 000 PLN

Project start date (Y-m-d): 2011-12-07

Project end date (Y-m-d): 2014-12-06

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Nucleofector AMAXA Lonza Verviers (60 000 PLN)

Information in the final report

  • Publication in academic press/journals (3)
  • Articles in post-conference publications (14)
  1. The PERK-eIF2α phosphorylation arm is a pro-survival pathway of BCR-ABL signaling and confers resistance to imatinib treatment in chronic myeloid leukemia cells.
    Authors:
    Kusio-Kobialka M, Podszywalow-Bartnicka P, Peidis P, Glodkowska-Mrowka E, Wolanin K, Leszak G, Seferynska I, Stoklosa T, Koromilas AE, Piwocka K
    Academic press:
    Cell Cycle (rok: 2012, tom: 11(21), strony: 4069-78), Wydawca: Landes Bioscience
    Status:
    Published
    DOI:
    10.4161/cc.22387. - link to the publication
  2. Downregulation of BRCA1 protein in BCR-ABL1 leukemia cells depends on stress-triggered TIAR-mediated suppression of translation
    Authors:
    Podszywalow-Bartnicka P, Wolczyk M, Kusio-Kobialka M, Wolanin K, Skowronek K, Nieborowska-Skorska M, Dasgupta Y, Skorski T & Piwocka K
    Academic press:
    Cell Cycle (rok: 2014, tom: 13 (24), strony: 3727-3741), Wydawca: Taylor & Francis Online
    Status:
    Published
    DOI:
    10.4161/15384101.2014.965013 - link to the publication
  3. Assembly of stress granules influences detection of mRNA by SmartFlare live RNA Probes; a novel aspect of the SmartFlare technology
    Authors:
    Magdalena Wolczyk, Lukasz Bugajski, Paulina Podszywalow-Bartnicka, Katarzyna Piwocka
    Academic press:
    Nucleic Acid Research (rok: 2015, tom: nie dotyczy, strony: nie dotyczy), Wydawca: Oxford Journals
    Status:
    Submitted
    DOI:
    brak - link to the publication
  1. BRCA1 translation in leukemia; role of mRNA binding proteins.
    Authors:
    Katarzyna Piwocka - invited talk
    Conference:
    19th World Congress on Advances in Oncology and 17th International Symposium on Molecular Medicine (rok: 2014, ), Wydawca: spandidos-publications
    Data:
    konferencja 9-11.10.2014 Ateny, Grecja
    Status:
    Published
    DOI:
    link to the publication
  2. Downregulation of BRCA1 Protein in BCR-ABL1–positive Cells Depends on Tiar-Mediated Repression of BRCA1 mRNA Translation
    Authors:
    Podszywalow-Bartnicka P, Wolczyk M, Kusio-Kobialka M, Wolanin K, Skowronek K, Nieborowska-Skorska M, Dasgupta Y, Skorski T and Piwock K
    Conference:
    56th ASH Annual Meeting and Exposition (rok: 2014, ), Wydawca: ASH
    Data:
    konferencja 6-9 Dec. 2014, San Francisco, USA
    Status:
    Published
    DOI:
    link to the publication
  3. Exchange of microvesicles secreted by leukemia cells and bone marrow stroma fibroblasts modifies behavior of targeted cells.
    Authors:
    Podszywałow-Bartnicka P, Bugajski L, Cmoch A, Tkaczyk M, Pikula S, Dadlez M, Piwocka K.
    Conference:
    EMBO/EMBL Tumor microenvironment and signaling. (rok: 2014, ), Wydawca: EMBO
    Data:
    konferencja 7-10 maja 2014, Heidelberg, Niemcy
    Status:
    Published
  4. Two faces of ER stress - from cancer to neurodegenerative diseases
    Authors:
    Piwocka K, Kusio‐Kobialka M, Dudka‐Ruszkowska W, Brewinsk‐Olchowik M, Krysa W, Rakowicz M, Stepniak I, Sulek A
    Conference:
    12th International Symposium Molecular Basis of Pathology and Therapy in Neurological Disorders" (rok: 2014, ), Wydawca: IMDiK PAN
    Data:
    konferencja 20-21.11.2014 Warszawa
    Status:
    Published
    DOI:
    link to the publication
  5. SmartFlare Probes Detect Only the Translationally Available mRNA in Live Cells, but Not the Total Pool of mRNA Quantified by Real - Time RT - PCR: A Novel Limitation of the Method
    Authors:
    K. Piwocka, M. Wolczyk, L. Bugajski a nd P. Podszywalow - Bartnicka
    Conference:
    XXX Congress of the International Society for Advancement of Cytometry Cyto2015 (rok: 2015, ), Wydawca: ISAC
    Data:
    konferencja 26-30 June 2015, Glasgow UK
    Status:
    Published
    DOI:
    link to the publication
  6. Targeting eIF2alpha phosphorylation shows anti-leukemic potential and attenuates secretion of pro-inflammatory cytokines and stroma-modifying factors by CML cells
    Authors:
    Wioleta Dudka-Ruszkowska1,*, Paulina Podszywalow-Bartnicka1, Monika Kusio-Kobialka, Magdalena Wolczyk, Michal Dadlez, Marta Tkaczyk,Grazyna Hoser, Michal Dabrowski, Antonis E. Koromilas and Katarzyna Piwocka
    Conference:
    International Conference on The Tumour Microenvironment in the Haematological Malignancies and its Therapeutic Targeting (rok: 2015, ), Wydawca: ESH
    Data:
    konferencja 7-9.05. 2015
    Status:
    Published
  7. mRNA binding proteins regulate BRCA1 mRNA translation in CML cells.
    Authors:
    Magdalena Wolczyk, Paulina Podszywalow-Bartnicka, Tomasz Skorski, Margaret Nieborowska-Skorska, Krzysztof Skowronek, Katarzyna Piwocka
    Conference:
    FEBS/EMBO Congress 2014 (rok: 2014, ), Wydawca: FEBS
    Data:
    konferencja 30 VIII - 4 IX 2014 Paryż, Francja
    Status:
    Published
    DOI:
    link to the publication
  8. Targeting the eIF2alpha phosphorylation shows therapeutic potential for chronic myeloid leukemia
    Authors:
    Wioleta Dudka-Ruszkowska1,*, Paulina Podszywalow-Bartnicka, Monika Kusio-Kobialka, Magdalena Wolczyk, Grazyna Hoser, Michal Dabrowski, Marta Tkaczyk, Michal Dadlez, Antonis E. Koromilas and Katarzyna Piwocka
    Conference:
    17th Annual John Goldman Conference on Chronic Myeloid Leukemia: Biology and Therapy (rok: 2015, ), Wydawca: ESH
    Data:
    konferencja 1-4.10.2015
    Status:
    Accepted for publication
    DOI:
    link to the publication
  9. Role of mRNA binding proteins in BRCA1 mRNA translation in leukemia cells
    Authors:
    Wolczyk M, Podszywalow-Bartnicka P, Skorski T, Nieborowska-Skorska M, Skowronek K, Piwocka K
    Conference:
    Kongres BIO 2014 (rok: 2014, ), Wydawca: PTBioch
    Data:
    konferencja 9-12 IX 2014, Warszawa
    Status:
    Published
    DOI:
    link to the publication
  10. Simultaneus tracking of cell type, viability, proliferation and expression of intracellular proteins in co-culture of leukemia and HS-5 stroma cells using multiparameter flow cytometry.
    Authors:
    Piwocka K, Podszywalow-Bartnicka P, Brewinska-Olchowik M, Bugajski L, Kusio-Kobialka M
    Conference:
    28th Congress of the International Society for Advancement of Cytometry CYTO2013 (rok: 2013, ), Wydawca: International Society for Advancement of Cytometry ISAC
    Data:
    konferencja 19-22 May 2013, San Diego, USA
    Status:
    Published
  11. Mechanism of BRCA1 mRNA down-regulation in BCR-ABL expressing cells
    Authors:
    Podszywalow-Bartnicka P , Dydo M , Kusio-Kobialka M , Wilson L , Willis A , Piwocka K.
    Conference:
    The First Polish-German Biochemical Societies Joint Meeting (rok: 2012, ), Wydawca: Polskie Towarzystwo Biochemiczne
    Data:
    konferencja 11 - 14 września 2012
    Status:
    Published
    DOI:
    link to the publication
  12. Multiparameter flow cytometry analysis of viability, proliferation and expression of intracellular proteins in co-cultures of leukemia and stroma cells.
    Authors:
    Podszywalow-Bartnicka k, Brewinska-Olchowik M, Bugajski L, Kusio-Kobialka M, Piwocka K
    Conference:
    Conference on Cytometry and Immunopathology (rok: 2013, ), Wydawca: Polish Society of Cytometry
    Data:
    konferencja 16-17. 05. 2013, Poznan
    Status:
    Published
  13. Regulation of BRCA1 mRNA translation by BCR-ABL1-HuR axis
    Authors:
    Podszywalow-Bartnicka P, Dydo M, Kusio-Kobialka M, Skowronek K, Nieborowska-Skorska M, Skorski T, Piwocka k
    Conference:
    ESH-iCMLf 15th International Conference on Chronic Myeloid Leukemia: Biology and Therapy (rok: 2013, ), Wydawca: European School of Haematology
    Data:
    konferencja 26-29. Oct. 2013, Estoril, Portugalia
    Status:
    Published
  14. SmartFlare RNA probes detect only translationally active but not stored in stress granules BRCA1 mRNA in CML cells
    Authors:
    Magdalena Wolczyk, Lukasz Bugajski, Paulina Podszywalow-Bartnicka, Katarzyna Piwocka
    Conference:
    EMBO Conference: Protein Synthesis and Translational Control (rok: 2015, ), Wydawca: EMBO
    Data:
    konferencja 9-13.09.2015
    Status:
    Published

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