Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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The role of oncogenic ras in deregulation of BNIP3 protein in hypoxic cancer cells. Implication for cancer cell survival, autophagy and chemoresistance

2011/01/B/NZ4/00938

Keywords:

ras BNIP3 cancer hypoxia NR4A1

Descriptors:

  • NZ4_11: Metabolism
  • NZ1_1: Molecular biology
  • NZ3_1: Cell biology

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Instytut Immunologii i Terapii Doświadczalnej im. Ludwika Hirszfelda PAN

woj. dolnośląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Leon Strządała 

Number of co-investigators in the project: 8

Call: OPUS 1 - announced on 2011-03-15

Amount awarded: 370 000 PLN

Project start date (Y-m-d): 2011-12-16

Project end date (Y-m-d): 2014-12-15

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Inkubator CO2-O2 NU-4950E (40 000 PLN)

Information in the final report

  • Publication in academic press/journals (5)
  • Articles in post-conference publications (3)
  1. Non-genomic effects of the NR4A1/Nur77/TR3/NGFIB orphan nuclear receptor
    Authors:
    3. Pawlak A., Strządała L., Kałas W.
    Academic press:
    Steroids (rok: 2015, tom: 95, strony: 1–6), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.steroids.2014.12.020 - link to the publication
  2. The interplay between epigenetic silencing, oncogenic KRas and HIF-1 regulatory pathways in control of BNIP3 expression in human colorectal cancer cells
    Authors:
    Swiderek E, Kalas W, Wysokinska E, Pawlak A, Rak J, Strzadala L.
    Academic press:
    Biochem Biophys Res Commun. (rok: 2013, tom: 441, strony: 707-12.), Wydawca: Elsevier B.V.
    Status:
    Published
    DOI:
    10.098. - link to the publication
  3. Autophagy and BNIP3 protein in tumorogenesis
    Authors:
    Świderek E., Strządała L
    Academic press:
    Post. Hig. Med. Dośw. (rok: 2013, tom: 67, strony: 363-70), Wydawca: Index Copernicus International
    Status:
    Published
    DOI:
    10.5604/17322693.1048712 - link to the publication
  4. Detection of autophagy based on conversions of MAP1LC3 and p62/SQSTM1
    Authors:
    Wysokińska E, Kałas W.
    Academic press:
    Postepy Hig Med Dosw (rok: 2013, tom: 67, strony: 442-8), Wydawca: Index Copernicus International
    Status:
    Published
    DOI:
    10.5604/17322693.1050029 - link to the publication
  5. Thrombospondin-1 receptor mediates autophagy of RAS-expressing cancer cells and triggers tumour growth inhibition
    Authors:
    Kalas W, Swiderek E, Switalska M, Wietrzyk J, Rak J, Strzadala L.
    Academic press:
    Anticancer Res. (rok: 2013, tom: 33, strony: 1429-38), Wydawca: The International Institute of Anticancer Research
    Status:
    Published
    DOI:
    brak - link to the publication
  1. Role of the Ras in regulation of BNIP3 expression in glioblastoma cells
    Authors:
    Wysokińska E., Kałas W., Pawlak A., Zioło E., Strzadała L
    Conference:
    12th International Symposium Molecular basis of pathology andtherapy in neurological disorders (rok: 2014, ), Wydawca: Folia Neuropathologica
    Data:
    konferencja 20-21.11
    Status:
    Published
    DOI:
    link to the publication
  2. Rysunki do sprawozdania merytorycznego
    Authors:
    Leon Strządała
    Conference:
    IITD (rok: 2015, ), Wydawca: IITD
    Data:
    konferencja styczeń 2015
    Status:
    Submitted
  3. The negligible effect of BNIP3 expression on the sensitivity of DLD-1 cells to etoposide,
    Authors:
    Wysokińska E., Puniach M., Pawlak A., Śliwak A., Zioło E., Kałas W., Strządała L.
    Conference:
    48 Zjazd Polskiego Towarzystwa Biochemicznego (rok: 2013, ), Wydawca: Polskie Towarzystwo Biochemiczne
    Data:
    konferencja 2 - 5 września 2013 r
    Status:
    Published
    DOI:
    link to the publication

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