Projects funded by the NCN

Small-molecule inhibitors for characterization of the interaction between extracellular domains of Programmed Cell Death...

Call: MAESTRO 9 , Panel: ST5

Principal investigator: prof. Tadeusz Holak

Uniwersytet Jagielloński, Wydział Chemii

Multiscale investigations on polymorphism of the beta2-adrenergic receptor: from molecular-scale processes to heart fail...

Call: OPUS 13 , Panel: NZ7

Principal investigator: dr hab. Anita Płazińska

Uniwersytet Medyczny w Lublinie, Wydział Farmaceutyczny

The influence of impairment of extracellular nucleoside and nucleotide signaling on synaptic structure and function in a...

Call: OPUS 13 , Panel: NZ4

Principal investigator: dr hab. Agata Adamczyk

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego Polskiej Akademii Nauk

Development of unique molecular probes: low-basicity agonists for the study of 5-HT7 receptor function

Call: OPUS 13 , Panel: NZ7

Principal investigator: prof. Andrzej Bojarski

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

Neutral homo- and heteronuclear bismacrocyclic metal complexes as components of interlocked molecules.

Call: PRELUDIUM 1 , Panel: ST5

Principal investigator: Iwona Mames

Instytut Chemii Organicznej Polska Akademia Nauk

Novel ligands of histamine receptor H4 as potential anti-allergic and anti-inflammatory drugs

Call: OPUS 13 , Panel: NZ7

Principal investigator: prof. Sławomir Filipek

Uniwersytet Warszawski, Wydział Chemii

Designing and application of synthetic receptors for protein hormones

Call: OPUS 13 , Panel: ST4

Principal investigator: dr hab. Piyush Sindhu Sharma

Instytut Chemii Fizycznej Polskiej Akademii Nauk

Host receptors involved in bacteriophage adsorption to Dickeya solani and Pectobacterium parmentieri cells and the ecolo...

Call: OPUS 13 , Panel: NZ9

Principal investigator: dr hab. Robert Czajkowski

Uniwersytet Gdański, Międzyuczelniany Wydział Biotechnologii Uniwersytetu Gdańskiego i Gdańskiego Uniwersytetu Medycznego

Evaluation of the anticancer efficacy of a new chimeric antigen receptor targeting PD-L1 molecule

Call: OPUS 12 , Panel: NZ6

Principal investigator: dr hab. Radosław Zagożdżon

Warszawski Uniwersytet Medyczny, Wydział Lekarski

Molecular modeling of allosteric binding and allosteric-orthosteric coupling in cannabinoid receptor CB1

Call: PRELUDIUM 12 , Panel: NZ1

Principal investigator: Jakub Jakowiecki

Uniwersytet Warszawski, Wydział Chemii

Development of novel light-controllable azobenzene switches as molecular receptors for selective sensing and transport o...

Call: SONATA 12 , Panel: ST5

Principal investigator: dr Kajetan Dąbrowa

Instytut Chemii Organicznej Polskiej Akademii Nauk

The effect of membrane domains on the G protein-lipid interactions

Call: OPUS 12 , Panel: NZ1

Principal investigator: dr Agnieszka Polit

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

The role of (R,S)-Sulforaphane-induced activation of Nrf2 transcription factor in the regulation of depressive-like beha...

Call: PRELUDIUM 12 , Panel: NZ4

Principal investigator: dr Patrycja Pańczyszyn-Trzewik

Uniwersytet Rzeszowski, Kolegium Nauk Medycznych

Characteristic of plant extracts inhibit the binding of Shiga toxin to Gb3 receptors.

Call: PRELUDIUM 12 , Panel: NZ1

Principal investigator: Magdalena Komiażyk-Mikulska

Instytut Biologii Doświadczalnej im. M. Nenckiego Polskiej Akademii Nauk

Molecular identification of signalling pathways activated by receptor kinase CRK5 during senescence and stress response ...

Call: SONATA 12 , Panel: NZ1

Principal investigator: dr Paweł Burdiak

Szkoła Główna Gospodarstwa Wiejskiego w Warszawie, Instytut Biologii

Piperazine derivatives as active histamine H3 receptor ligands - molecular modeling, synthesis, pharmacological evaluati...

Call: PRELUDIUM 12 , Panel: NZ7

Principal investigator: Katarzyna Szczepańska

Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

Study of the hormonal and molecular mechanisms of tumorigenesis in the interstitial tissue of the male gonad

Call: OPUS 12 , Panel: NZ4

Principal investigator: prof. Barbara Bilińska

Uniwersytet Jagielloński, Wydział Biologii

Impact of palmitoylation on the Zn(II)-dependent interaction between CD4 coreceptor and Lck tyrosine kinase.

Call: PRELUDIUM 11 , Panel: NZ1

Principal investigator: Anna Kocyła

Uniwersytet Wrocławski, Wydział Biotechnologii

Molecular receptors as a tool for studies of interactions agonist/antagonist of H1 - H4 receptors

Call: PRELUDIUM 11 , Panel: ST5

Principal investigator: Małgorzata Walczak

Politechnika Łódzka, Wydział Chemiczny

Structural studies of signaling receptors HVEM/CD160 as potential targets for immunoterapy against melanoma

Call: SONATA 11 , Panel: NZ1

Principal investigator: dr Marta Orlikowska

Uniwersytet Gdański, Wydział Chemii

Molecular propellers, bevel gears and sea anemones - dynamically chiral triarylmethyl derivatives as versatile stereoche...

Call: OPUS 11 , Panel: ST5

Principal investigator: dr hab. Marcin Kwit

Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Chemii

The function of EBI2 receptor in human oligodendrocytes and its role in the cuprizone model for demyelination.

Call: POLONEZ 2 , Panel: NZ3

Principal investigator: dr Aleksandra Rutkowska

Gdański Uniwersytet Medyczny, Wydział Lekarski

Studies on the steric structure and stability of the gas-phase complexes of macrocyclic receptors with anions using ion ...

Call: OPUS 11 , Panel: ST4

Principal investigator: prof. Witold Danikiewicz

Instytut Chemii Organicznej Polskiej Akademii Nauk

Comparison of adhesive properties and traction forces in bladder cancer cells of various malignancies cultured on polyme...

Call: PRELUDIUM 11 , Panel: NZ1

Principal investigator: Joanna Danilkiewicz

Instytut Fizyki Jądrowej im. Henryka Niewodniczańskiego Polskiej Akademii Nauk

Pochodne azulenu jako bloki budulcowe w konstrukcji selektywnych receptorów anionów

Call: ETIUDA 4 , Panel: ST5

Principal investigator: Dawid Lichosyt

Instytut Chemii Organicznej Polskiej Akademii Nauk

Molecular and functional analysis of interleukin 18 (IL-18) its receptor (IL-18R) and IL-18- binding protein (IL-18BP) i...

Call: PRELUDIUM 10 , Panel: NZ6

Principal investigator: Sebastian Wawrocki

Uniwersytet Łódzki, Wydział Biologii i Ochrony Środowiska

In vitro and in vivo preclinical studies of NaA nanozeolite functionalized with antibodies anti-PSMA and labeled with ra...

Call: OPUS 10 , Panel: NZ7

Principal investigator: prof. Anna Lankoff

Instytut Chemii i Techniki Jądrowej

The role of the neuron-microglia CX3CL1-CX3CR1 and CD200-CD200R protein systems in molecular mechanisms of antipsychotic...

Call: OPUS 10 , Panel: NZ7

Principal investigator: prof. Agnieszka Basta-Kaim

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

Molecular mechanism of interactions between GPCRs and G protein.

Call: PRELUDIUM 10 , Panel: NZ2

Principal investigator: Stefan Mordalski

Instytut Farmakologii Polskiej Akademii Nauk

Gene and protein analysis of OPRM1/MOR and OPRK1/KOR opioid receptors expression and neurobiological marker of nerve ter...

Call: PRELUDIUM 1 , Panel: NZ4

Principal investigator: Piotr Kupczyk

Instytut Immunologii i Terapii Doświadczalnej im. Ludwika Hirszfelda PAN

Synthesis and Struktural Characterization of Small-Molecule Probes for the Programmed Death 1/ Programmed Death Ligand 1...

Call: PRELUDIUM 10 , Panel: ST5

Principal investigator: Katarzyna Guzik

Uniwersytet Jagielloński, Wydział Chemii

Molecular mechanisms of nucleic acids receptors signalling regulation by Pellino 3 protein during viral infection.

Call: SONATA BIS 5 , Panel: NZ3

Principal investigator: dr hab. Jakub Siednienko

Sieć Badawcza ŁUKASIEWICZ - PORT Polski Ośrodek Rozwoju Technologii

Interdisciplinary studies into molecular mechanisms of conformational transitions underlying GABAA receptor activation

Call: MAESTRO 7 , Panel: NZ1

Principal investigator: prof. Jerzy Mozrzymas

Uniwersytet Medyczny im. Piastów Śląskich we Wrocławiu, Wydział Lekarski

A virtual screening protocol based on automatically generated structure-based pharmacophore models.

Call: HARMONIA 7 , Panel: NZ2

Principal investigator: Stefan Mordalski

Instytut Farmakologii PAN

Estrogen signaling in male gonad from birth to aging. Study of the molecular mechanisms of cellular processes in mammali...

Call: SONATA BIS 5 , Panel: NZ4

Principal investigator: dr hab. Małgorzata Kotula-Balak

Uniwersytet Jagielloński, Wydział Biologii

Searching for the new lead structures for 5-HT7 serotonin receptor ligands with increased metabolic stability.

Call: HARMONIA 7 , Panel: NZ7

Principal investigator: Sabina Podlewska

Instytut Farmakologii PAN

Synthesis and binding studies of new podands based on 1,8-diaminocarbazole moiety

Call: PRELUDIUM 9 , Panel: ST5

Principal investigator: Krzysztof Bąk

Uniwersytet Warszawski, Wydział Chemii

Metabolic profiling of HIF stabilizers, PPAR agonists and SARMs by means of UPLC-MS/MS.

Call: PRELUDIUM 9 , Panel: ST4

Principal investigator: Katarzyna Kowalczyk

Uniwersytet Warszawski, Wydział Chemii

Rational design and pharmacological characterization of chimeric cyclic opioid peptide analogs targeting multiple recept...

Call: OPUS 9 , Panel: ST5

Principal investigator: prof. Anna Janecka

Uniwersytet Medyczny w Łodzi, Wydział Lekarski

Synthesis of new glutamate receptors antagonists and extensive investigation of their effect on tumor cells in the prese...

Call: OPUS 9 , Panel: ST5

Principal investigator: prof. Maria Bretner

Politechnika Warszawska, Wydział Chemiczny