Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Deciphering the promiscuous bioinorganic chemistry of putative copper transporters in bacteria

2023/51/D/ST5/01798

Keywords:

bioinorganic chemistry copper homeostasis bacterial copper transporters antimicrobial resistance thermodynamic cysteine and methionine ligands UV-Vis CD NMR EPR spectroscopy mass spectrometry ITC potentiometry

Descriptors:

  • ST5_14:
  • ST5_10:
  • ST5_15:

Panel:

ST5 - Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering

Host institution :

Uniwersytet Wrocławski, Wydział Chemii

woj. dolnośląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Aleksandra Anna Hecel-Czaplicka 

Number of co-investigators in the project: 4

Call: SONATA 19 - announced on 2023-09-18

Amount awarded: 1 794 620 PLN

Project start date (Y-m-d): 2024-07-10

Project end date (Y-m-d): 2027-07-09

Project duration:: 36 months (the same as in the proposal)

Project status: Pending project

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (4)
  1. Small Cysteine-Rich Motif, Big Function─Metal-Driven Dimerization of the CopY C-Terminal Fragment
    Authors:
    Hecel Aleksandra*, Kola Arian, Domínguez-Martín Alicia, Valensin Daniela
    Academic press:
    Inorganic Chemistry (rok: 2025, tom: 64, strony: 22615-22630), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acs.inorgchem.5c03226?urlappend=%3Fref%3DPDF&jav=VoR&rel=cite-as - link to the publication
  2. Two sites, two stories: sequence-driven divergence in Cu(II) and Zn(II) binding to CusF
    Authors:
    Pakowski Michał, Hecel Aleksandra*
    Academic press:
    Dalton Transactions (rok: 2025, tom: 54, strony: 15441-15454), Wydawca: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/D5DT01770J - link to the publication
  3. AdcA lipoprotein involved in Zn(ii) transport in Streptococcus mutans – is it as metal-specific as expected?
    Authors:
    Garstka Kinga, Hecel Aleksandra*, Kozłowski Henryk, Domínguez-Martín Alicia, Szewczyk Krzysztof, Rowińska-Żyrek Magdalena
    Academic press:
    Dalton Transactions (rok: 2025, tom: 54, strony: 6795-6804), Wydawca: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/d5dt00131e - link to the publication
  4. Thiol, His–His Motif, and the Battle over Cu(II) in the Relationship of CopM Metallophore and OprC Outer Membrane Protein
    Authors:
    Hecel Aleksandra*, Kola Arian, Valensin Daniela, Witkowska Danuta
    Academic press:
    Inorganic Chemistry (rok: 2025, tom: 64, strony: 2936-2950), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acs.inorgchem.4c05101 - link to the publication

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