Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Step beyond classical lipophilicity - modeling of phospholipids affinity using immobilized artificial membranes chromatography and machine learning approach – development of new bioinformatical tools

2022/47/D/NZ7/01043

Keywords:

Quantitative Structure–Retention Relationships chemometrics IAM-HPLC machine learning phospholipids

Descriptors:

  • NZ7_014:
  • ST4_005:

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Gdański Uniwersytet Medyczny, Wydział Farmaceutyczny

woj. pomorskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Krzesimir Ciura 

Number of co-investigators in the project: 4

Call: SONATA 18 - announced on 2022-07-15

Amount awarded: 782 400 PLN

Project start date (Y-m-d): 2023-07-21

Project end date (Y-m-d): 2026-07-20

Project duration:: 36 months (the same as in the proposal)

Project status: Pending project

Project description

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Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (6)
  1. Modification of gradient HPLC method for determination of small molecules' affinity to human serum albumin under column safety conditions: Robustness and chemometrics study
    Authors:
    M. Woziński, K.E. Greber, M. Pastewska, P. Kolasiński, W. Hewelt-Belka, B. Żołnowska, J. Sławiński, D. Szulczyk, W. Sawicki, K. Ciura,
    Academic press:
    Journal of Pharmaceutical and Biomedical Analysis (rok: 2023, tom: 239, strony: 8), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jpba.2023.115916 - link to the publication
  2. Evaluation of Physicochemical Properties of Ipsapirone Derivatives Based on Chromatographic and Chemometric Approaches
    Authors:
    W. Nisterenko, D. Kułaga, M. Woziński, Y.R. Singh, B. Judzińska, K. Jagiello, K.E. Greber, W. Sawicki, K. Ciura
    Academic press:
    Molecules (rok: 2024, tom: 29, strony: 12), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules29081862 - link to the publication
  3. Exploration and optimisation of structure-activity relationships of new triazole-based C-terminal Hsp90 inhibitors towards in vivo anticancer potency
    Authors:
    J. Dernovšek, Ž. Zajec, G. Poje, D. Urbančič, C. Sturtzel, T. Goričan, S. Grissenberger, K. Ciura, M. Woziński, M. Gedgaudas, A. Zubrienė, S.G. Grdadolnik, I. Mlinarič-Raščan, Z. Rajić, A.E. Cotman, N. Zidar, M. Distel, T. Tomašič
    Academic press:
    Biomedicine & Pharmacotherapy (rok: 2024, tom: 177, strony: 29), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.biopha.2024.116941 - link to the publication
  4. Green synthesis of 1,3,5-triazine derivatives using a sonochemical protocol
    Authors:
    D. Kułaga, A.K. Drabczyk, P. Zaręba, J. Jaśkowska, J. Chrzan, K.E. Greber, K. Ciura, D. Plażuk, E. Wielgus
    Academic press:
    Ultrasonics Sonochemistry (rok: 2024, tom: 108, strony: 11), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ultsonch.2024.106951 - link to the publication
  5. Low-Basicity 5-HT6 Receptor Ligands from the Group of Cyclic Arylguanidine Derivatives and Their Antiproliferative Activity Evaluation
    Authors:
    P. Zaręba, A.K. Drabczyk, A. Wnorowski, M. Maj, K. Malarz, P. Rurka, G. Latacz, B. Duszyńska, K. Ciura, K.E. Greber, A. Boguszewska-Czubara, P. Śliwa, J. Kuliś, Low-Basicity 5-HT6 Receptor Ligands from the Group of Cyclic Arylguanidine Derivatives and Their Antiproliferative Activity Evaluation
    Academic press:
    International Journal of Molecular Sciences (rok: 2024, tom: 25, strony: 49), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms251910287 - link to the publication
  6. Modeling of small molecule's affinity to phospholipids using IAM-HPLC and QSRR approach enhanced by similarity-based machine algorithms
    Authors:
    K Ciura
    Academic press:
    Journal of Chromatography A (rok: 2024, tom: 1714, strony: 8), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.chroma.2023.464549 - link to the publication

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