Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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How age-related oxidative modification of neuromelanin and RPE melanin affect their protective properties in the human brain and eyes

2021/43/B/ST4/03255

Keywords:

neuromelanin RPE melanin Sunbstantia nigra retinal pigment epithelium neurodegenerative diseases oxidative stress oxidative modifications electron-exchange properties ion-exchange ability paramagnetic centers multifrequency EPR spectroscopy

Descriptors:

  • ST4_009:
  • NZ1_003:

Panel:

ST4 - Chemistry: physical chemistry/chemical physics, theoretical chemistry, analytical chemistry, inorganic chemistry, organic chemistry, method development

Host institution :

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Tadeusz Jan Sarna 

Number of co-investigators in the project: 4

Call: OPUS 22 - announced on 2021-09-15

Amount awarded: 1 956 200 PLN

Project start date (Y-m-d): 2022-07-12

Project end date (Y-m-d): 2027-07-11

Project duration:: 60 months (the same as in the proposal)

Project status: Pending project

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (2)
  1. The effect of oxidative degradation of Dopa-melanin on its basic physicochemical properties and photoreactivity
    Authors:
    Mokrzyński K, Żądło A, Szewczyk G, Sarna M, Camenisch TG, Ito S, Wakamatsu K, Sarna T
    Academic press:
    Pigment Cell and Melanoma Research (rok: 2024, tom: 37(6), strony: 769-782), Wydawca: Wiley
    Status:
    Published
    DOI:
    0.1111/pcmr.13176 - link to the publication
  2. SuperDopa (SD), SuperDopa amide (SDA) and Thioredoxin-mimetic peptides protect ARPE-19 cells from photic- and non-photic stress
    Authors:
    Olchawa, M., Szewczyk, G., Lachish, M., Sarna, T., Atlas, D
    Academic press:
    Journal of Photochemistry and Photobiology (rok: 2024, tom: 19, strony: 100225), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jpap.2023.100225 - link to the publication

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