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Mechanisms involved in heme acquisition - potential targets for therapies directed towards reduction of Porphyromonas gingivalis virulence

2021/41/B/NZ6/00702

Keywords:

Porphyromonas gingivalis heme uptake heme metabolism periodontal diseases virulence

Descriptors:

  • NZ6_004:
  • NZ1_010:
  • NZ6_008:

Panel:

NZ6 - Human and animal immunology and infection: immunity, immune disorders, immunotherapy, infectious and invasive diseases, microbiology, transplantology, allergology

Host institution :

Uniwersytet Wrocławski, Wydział Biotechnologii

woj. dolnośląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Michał Sylwester Śmiga 

Number of co-investigators in the project: 8

Call: OPUS 21 - announced on 2021-03-15

Amount awarded: 1 789 400 PLN

Project start date (Y-m-d): 2022-01-13

Project end date (Y-m-d): 2026-01-12

Project duration:: 48 months (the same as in the proposal)

Project status: Project completed

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (4)
  1. Defining the role of Hmu and Hus systems in Porphyromonas gingivalis heme and iron homeostasis and virulence
    Authors:
    Michał Śmiga, Paulina Ślęzak, Michał Tracz, Patryk Cierpisz, Mateusz Wagner, Teresa Olczak
    Academic press:
    Scientific Reports (rok: 2024, tom: 14, strony: 31156), Wydawca: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/s41598-024-82326-6 - link to the publication
  2. Hemophore-like proteins of the HmuY family in the oral and gut microbiome: unraveling the mystery of their evolution
    Authors:
    Teresa Olczak, Michał Śmiga, Svetlana V Antonyuk, John W Smalley
    Academic press:
    Microbiology and Molecular Biology Reviews (rok: 2024, tom: 88, strony: e0013123), Wydawca: American Society for Microbiology
    Status:
    Published
    DOI:
    10.1128/mmbr.00131-23 - link to the publication
  3. Interplay between Porphyromonas gingivalis hemophore-like protein HmuY and Kgp/RgpA gingipains plays a superior role in heme supply
    Authors:
    Michał Śmiga, Paulina Ślęzak, Mateusz Wagner, Teresa Olczak
    Academic press:
    Microbiology Spectrum (rok: 2023, tom: 11(2), strony: e0459322), Wydawca: ASM Journals
    Status:
    Published
    DOI:
    10.1128/spectrum.04593-22 - link to the publication
  4. Comparative analysis of Porphyromonas gingivalis A7436 and ATCC 33277 strains reveals differences in the expression of heme acquisition systems
    Authors:
    Michał Śmiga, Paulina Ślęzak, Teresa Olczak
    Academic press:
    Microbiology Spectrum (rok: 2024, tom: 12, strony: e02865-23), Wydawca: ASM Journals
    Status:
    Published
    DOI:
    10.1128/spectrum.02865-23 - link to the publication

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