Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Living on the edge: evolutionary adaptation of substrate-recruiting subunits of the cullin-RING ubiquitin ligase complexes to avoid premature degradation

2021/41/N/NZ1/03473

Keywords:

proteostasis adaptive protein evolution ubiquitin-proteasome system E3 ubiquitin ligase

Descriptors:

  • NZ1_1: Molecular biology
  • NZ3_1: Cell biology
  • NZ2_7: Bioinformatics

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Międzynarodowy Instytut Biologii Molekularnej i Komórkowej w Warszawie

woj.

Other projects carried out by the institution 

Principal investigator (from the host institution):

Natalia Anna Szulc 

Number of co-investigators in the project: 2

Call: PRELUDIUM 20 - announced on 2021-03-15

Amount awarded: 190 770 PLN

Project start date (Y-m-d): 2022-02-01

Project end date (Y-m-d): 2025-01-31

Project duration:: 36 months (the same as in the proposal)

Project status: Project completed

Project description

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Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (4)
  1. A novel de novo FEM1C variant is linked to neurodevelopmental disorder with absent speech, pyramidal signs and limb ataxia
    Authors:
    Abhishek Anil Dubey, Magdalena Krygier, Natalia A Szulc, Karolina Rutkowska, Joanna Kosińska, Agnieszka Pollak, Małgorzata Rydzanicz, Tomasz Kmieć, Maria Mazurkiewicz-Bełdzińska, Wojciech Pokrzywa, Rafał Płoski
    Academic press:
    Human Molecular Genetics (rok: 2022, tom: 32, strony: 1152–1161), Wydawca: Oxford University Press
    Status:
    Published
    DOI:
    10.1093/hmg/ddac276 - link to the publication
  2. In silico analysis of the profilaggrin sequence indicates alterations in the stability, degradation route, and intracellular protein fate in filaggrin null mutation carriers
    Authors:
    Argho Aninda Paul, Natalia A. Szulc, Adrian Kobiela, Sara J. Brown, Wojciech Pokrzywa, Danuta Gutowska-Owsiak
    Academic press:
    Frontiers in Molecular Biosciences (rok: 2023, tom: 10, strony: 45680), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fmolb.2023.1105678 - link to the publication
  3. Lysine deserts and cullin-RING ligase receptors: Navigating untrodden paths in proteostasis
    Authors:
    Natalia A. Szulc, Małgorzata Piechota, Lilla Biriczová, Pankaj Thapa, Wojciech Pokrzywa
    Academic press:
    iScience (rok: 2023, tom: 26, strony: 45681), Wydawca: Cell Press
    Status:
    Published
    DOI:
    10.1016/j.isci.2023.108344 - link to the publication
  4. A novel de novo FEM1C variant is linked to neurodevelopmental disorder with absent speech, pyramidal signs and limb ataxia
    Authors:
    Abhishek Anil Dubey, Magdalena Krygier, Natalia A Szulc, Karolina Rutkowska, Joanna Kosińska, Agnieszka Pollak, Małgorzata Rydzanicz, Tomasz Kmieć, Maria Mazurkiewicz-Bełdzińska, Wojciech Pokrzywa, Rafał Płoski
    Academic press:
    Human Molecular Genetics (rok: 2022, tom: 32, strony: 1152–1161), Wydawca: Oxford University Press
    Status:
    Published
    DOI:
    10.1093/hmg/ddac276 - link to the publication

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