Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

Delete all

Role of Nox2-ROS-Nlrp3 inflammasome axis in homing and engraftment of hematopoietic stem/progenitor cells

2021/41/B/NZ3/01589

Keywords:

Nox2 ROS Nlrp3 inflammasome HSPCs migration HSPCs homing

Descriptors:

  • NZ3_001:
  • NZ3_008:
  • NZ3_007:

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Warszawski Uniwersytet Medyczny

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Mariusz Zdzisław Ratajczak 

Number of co-investigators in the project: 5

Call: OPUS 21 - announced on 2021-03-15

Amount awarded: 2 405 840 PLN

Project start date (Y-m-d): 2022-01-21

Project end date (Y-m-d): 2026-05-20

Project duration:: 52 months (the same as in the proposal)

Project status: Project completed

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (17)
  1. Hematopoiesis Revolves Around the Primordial Evolutional Rhythm of Purinergic Signaling and Innate Immunity - A Journey to the Developmental Roots
    Authors:
    Ratajczak, M. Z., Bujko, K., Brzezniakiewicz-Janus, K., Ratajczak, J., & Kucia, M.
    Academic press:
    Stem cell reviews and reports (rok: 2024, tom: 20, strony: 827-838), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1007/s12015-024-10692-9 - link to the publication
  2. Intracellular Complement (Complosome) is Expressed in Several Types of Human Adult Bone Marrow-Derived Stem Cells
    Authors:
    Bujko, K., Brzenziakiewicz-Janus, K., Kucia, M., & Ratajczak, M. Z.
    Academic press:
    Stem cell reviews and reports (rok: 2024, tom: 20, strony: 437-439), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1007/s12015-023-10650-x - link to the publication
  3. Hematopoiesis Revolves Around the Primordial Evolutional Rhythm of Purinergic Signaling and Innate Immunity - A Journey to the Developmental Roots
    Authors:
    Ratajczak MZ, Bujko K, Brzezniakiewicz-Janus K, Ratajczak J, Kucia M
    Academic press:
    Stem cell reviews and reports (rok: 2023, tom: 1, strony: 46034), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s12015-024-10692-9 - link to the publication
  4. Very small embryonic-like stem cells (VSELs) on the way for potential applications in regenerative medicine
    Authors:
    Thetchinamoorthy, K., Jarczak, J., Kieszek, P., Wierzbicka, D., Ratajczak, J., Kucia, M., & Ratajczak, M. Z.
    Academic press:
    Frontiers in bioengineering and biotechnology (rok: 2025, tom: 13, strony: 1564964), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fbioe.2025.1564964 - link to the publication
  5. Intracellular Complement (Complosome) is Expressed in Several Types of Human Adult Bone Marrow-Derived Stem Cells
    Authors:
    Bujko K, Brzenziakiewicz-Janus K, Kucia M, Ratajczak MZ
    Academic press:
    Stem cell reviews and reports (rok: 2024, tom: 20, strony: 437-439), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s12015-023-10650-x - link to the publication
  6. The Nox2-ROS-Nlrp3 Inflammasome Signaling Stimulates in the Hematopoietic Stem/Progenitor Cells Lipogenesis to Facilitate Membrane Lipid Raft Formation
    Authors:
    Abdelbaset-Ismail A, Ciechanowicz AK, Bujko K, Ratajczak J, Kucia M, Ratajczak MZ.
    Academic press:
    Stem Cell Reviews and Reports (rok: 2022, tom: 19, strony: 92-103), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s12015-022-10481-2 - link to the publication
  7. Optimizing single cell RNA sequencing of stem cells. A streamlined workflow for enhanced sensitivity and reproducibility in hematopoietic studies. The use of human umbilical cord blood-derived hematopoietic stem and progenitor cells
    Authors:
    Jarczak, J., Kieszek, P., Ratajczak, M. Z., & Kucia, M.
    Academic press:
    Frontiers in cell and developmental biology (rok: 2025, tom: 13, strony: 1590889), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fcell.2025.1590889 - link to the publication
  8. NADPH oxidase isoform NOX-2 deficiency affects mitochondrial oxygen consumption and metabolic flexibility
    Authors:
    Thetchinamoorthy, K., Wierzbicka, D., Waraksa-Zasada, E., Kazek, M., Konopko, A., Ratajczak, M. Z., & Kucia, M.
    Academic press:
    Redox biology (rok: 2025, tom: 88, strony: 103948), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.redox.2025.103948 - link to the publication
  9. Pineal Gland Hormone Melatonin Inhibits Migration of Hematopoietic Stem/Progenitor Cells (HSPCs) by Downregulating Nlrp3 Inflammasome and Upregulating Heme Oxygenase-1 (HO-1) Activity
    Authors:
    Abdelbaset-Ismail, A., Brzezniakiewicz-Janus, K., Thapa, A., Ratajczak, J., Kucia, M., & Ratajczak, M. Z.
    Academic press:
    Stem cell reviews and reports (rok: 2024, tom: 20, strony: 237-246), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1007/s12015-023-10638-7 - link to the publication
  10. The Different Responsiveness of C3- and C5-deficient Murine BM Cells to Oxidative Stress Explains Why C3 Deficiency, in Contrast to C5 Deficiency, Correlates with Better Pharmacological Mobilization and Engraftment of Hematopoietic Cells
    Authors:
    Konopko, A., Łukomska, A., Kucia, M., & Ratajczak, M. Z.
    Academic press:
    Stem cell reviews and reports (rok: 2024, tom: 21(1), strony: 59-67), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1007/s12015-024-10792-6 - link to the publication
  11. Extracellular Adenosine (eAdo) - A2B Receptor Axis Inhibits in Nlrp3 Inflammasome-dependent Manner Trafficking of Hematopoietic Stem/progenitor Cells.
    Authors:
    Thapa A, Abdelbaset-Ismail A, Chumak V, Adamiak M, Brzezniakiewicz-Janus K, Ratajczak J, Kucia M, Ratajczak MZ.
    Academic press:
    Stem Cell Reviews and Reports (rok: 2022, tom: 18, strony: 2893-2911), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s12015-022-10417-w - link to the publication
  12. UDP-Glucose-P2Y14 Receptor Signaling Enhances the Responsiveness of Hematopoietic Stem/Progenitor Cells to Chemoattractants by Facilitating Membrane Lipid Raft Formation and Nlrp3 Inflammasome Activation
    Authors:
    Adamiak, M., Thetchinamoorthy, K., Wierzbicka, D., Kazek, M., Waraksa-Zasada, E., Lukomska, A., Brzezniakiewicz-Janus, K., Ratajczak, J., Kucia, M., & Z Ratajczak, M.
    Academic press:
    Stem cell reviews and reports (rok: 2026, tom: 26, strony: s12015), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1007/s12015-026-11104-w - link to the publication
  13. Complosome Regulates Hematopoiesis at the Mitochondria Leve
    Authors:
    Konopko, A., Łukomska, A., Ratajczak, J., Kucia, M., & Ratajczak, M. Z.
    Academic press:
    Stem cell reviews and reports (rok: 2025, tom: 10,1007, strony: s12015-025), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1007/s12015-025-10856-1 - link to the publication
  14. The NLRP3 Inflammasome Transmits Sterile Inflammation Signals to Sustain Proper Mitochondrial Electron Transport Chain Function and Influences Cellular Metabolism
    Authors:
    Konopko, A., Kazek, M., Waraksa-Zasada, E., Łukomska, A., Ratajczak, J., Kucia, M., & Ratajczak, M. Z.
    Academic press:
    Stem cell reviews and reports (rok: 2025, tom: 21, strony: 2157-2169), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1007/s12015-025-10948-y - link to the publication
  15. Complosome Activation after Myocardial Infarction in a Murine Model of Permanent LAD Ligation
    Authors:
    Ratajczak, J., Abdel-Latif, A., Schneider, G., Luther, T., Chaudhary, R., Shabani, P., Lopez, R., Alzamrooni, A., Singh, A. P., Jama, H., Kakar, S. S., Kucia, M., & Ratajczak, M.
    Academic press:
    Stem cell reviews and reports (rok: 2026, tom: 22, strony: 1023-1029), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1007/s12015-025-11044-x - link to the publication
  16. Defect in Migration of HSPCs in Nox-2 Deficient Mice Explained by Impaired Activation of Nlrp3 Inflammasome and Impaired Formation of Membrane Lipid Rafts
    Authors:
    Brzezniakiewicz-Janus, K., Kucia, M., & Ratajczak, M. Z.
    Academic press:
    Stem cell reviews and reports (rok: 2024, tom: 21(1), strony: 45-58), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1007/s12015-024-10775-7 - link to the publication
  17. Murine and Human-Purified very Small Embryonic-like Stem Cells (VSELs) Express Purinergic Receptors and Migrate to Extracellular ATP Gradient.
    Authors:
    Bujko, K., Brzezniakiewicz-Janus, K., Jarczak, J., Kucia, M., & Ratajczak, M. Z.
    Academic press:
    Stem cell reviews and reports (rok: 2024, tom: 20 (5), strony: 1357-1366), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1007/s12015-024-10716-4 - link to the publication

O Narodowym Centrum Nauki

Finansowanie nauki

Współpraca zagraniczna

Centrum prasowe

Deklaracja dostępności
Przetwarzanie danych osobowych
Polityka cookies

Partnerzy