Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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STRUCTURAL BASIS OF TRANSMISSIBLE FLUOROQUINOLONE RESISTANCE

2020/39/B/NZ1/02898

Keywords:

antibiotics fluoroquinolones pentapeptide repeat proteins DNA gyrase cryo-electron microscopy topoisomerases

Descriptors:

  • NZ1_4: Structural biology
  • NZ1_10: Microbiology
  • NZ1_1: Molecular biology

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Uniwersytet Jagielloński, Małopolskie Centrum Biotechnologii Uniwersytetu Jagiellońskiego

woj.

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Marta Hanna Pabiś 

Number of co-investigators in the project: 5

Call: OPUS 20 - announced on 2020-09-15

Amount awarded: 2 288 532 PLN

Project start date (Y-m-d): 2021-07-12

Project end date (Y-m-d): 2025-07-11

Project duration:: 48 months (the same as in the proposal)

Project status: Pending project

Project description

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Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (3)
  1. Molecular mechanism of topoisomerase poisoning by the peptide antibiotic albicidin
    Authors:
    Elizabeth Michalczyk, Kay Hommernick, Iraj Behroz, Marcel Kulike, Zuzanna Pakosz-Stępień, Lukasz Mazurek, Maria Seidel, Maria Kunert, Karine Santos, Holger von Moeller, Bernhard Loll, John B. Weston, Andi Mainz, Jonathan G. Heddle, Roderich D. Süssmuth, Dmitry Ghilarov
    Academic press:
    Nature Catalysis (rok: 2023, tom: 6, strony: 52-67), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1038/s41929-022-00904-1 - link to the publication
  2. Gene amplifications cause high-level resistance against albicidin in gram-negative bacteria
    Authors:
    Mareike Saathoff, Simone Kosol, Torsten Semmler, Karsten Tedin, Nicole Dimos, Johannes Kupke, Maria Seidel, Fereshteh Ghazisaeedi, Micela Condor Jonske, Silver A. Wolf, Benno Kuropka, Wojciech Czyszczoń, Dmitry Ghilarov, Stefan Grätz, Jonathan G. Heddle, Bernhard Loll, Roderich D. Süssmuth, Marcus Fulde
    Academic press:
    PLOS BIOLOGY (rok: 2023, tom: 21(8), strony: 45675), Wydawca: PLOS
    Status:
    Published
    DOI:
    10.1371/journal.pbio.3002186 - link to the publication
  3. Molecular mechanism of topoisomerase poisoning by the peptide antibiotic albicidin
    Authors:
    Elizabeth Michalczyk, Kay Hommernick, Iraj Behroz, Marcel Kulike, Zuzanna Pakosz-Stępień, Lukasz Mazurek, Maria Seidel, Maria Kunert, Karine Santos, Holger von Moeller, Bernhard Loll, John B. Weston, Andi Mainz, Jonathan G. Heddle, Roderich D. Süssmuth, Dmitry Ghilarov
    Academic press:
    Nature Catalysis (rok: 2023, tom: 6, strony: 52-67), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1038/s41929-022-00904-1 - link to the publication

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