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The effect of cancer somatic mutations in miRNA genes on the functioning of these genes and their potential role in cancer

2020/39/D/NZ2/03106

Keywords:

miRNA somatic mutations cancer

Descriptors:

  • NZ2_1: Molecular genetics
  • NZ2_2: Genomics, transcriptomics, epigenomics
  • NZ5_1: Etiology of human diseases

Panel:

NZ2 - Genetics, genomics: molecular genetics, genomics, proteomics, bioinformatics, systems biology, genetic epidemiology

Host institution :

Instytut Chemii Bioorganicznej Polskiej Akademii Nauk

woj.

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Paulina Małgorzata Gałka-Marciniak 

Number of co-investigators in the project: 3

Call: SONATA 16 - announced on 2020-09-15

Amount awarded: 1 599 200 PLN

Project start date (Y-m-d): 2021-09-01

Project end date (Y-m-d): 2024-08-31

Project duration:: 36 months (the same as in the proposal)

Project status: Project completed

Project description

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Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (6)
  1. Mutations in the miR-142 gene are not common in myeloproliferative neoplasms
    Authors:
    Paulina Galka-Marciniak, Zuzanna Kanduła, Adrian Tire, Wladysław Wegorek , Karolina GwozdzBak , Luiza Handschuh, Maciej Giefing , Krzysztof Lewandowski , Piotr Kozlowski
    Academic press:
    Scientific Reports (rok: 2022, tom: 12, strony: 10924), Wydawca: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/s41598-022-15162-1 - link to the publication
  2. Consequences of genetic variants in miRNA genes
    Authors:
    Magdalena Machowska, Paulina Galka-Marciniak, Piotr Kozlowski
    Academic press:
    Computational and Structural Biotechnology Journal (rok: 2022, tom: 20, strony: 6443-6457), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.csbj.2022.11.036 - link to the publication
  3. miRMut: Annotation of mutations in miRNA genes from human whole-exome or whole-genome sequencing
    Authors:
    Martyna O. Urbanek-Trzeciak, Piotr Kozlowski and Paulina Galka-Marciniak
    Academic press:
    STAR Protocols (rok: 2022, tom: 3, strony: 101023), Wydawca: Cell Press
    Status:
    Published
    DOI:
    10.1016/j.xpro.2021.101023 - link to the publication
  4. Consequences of genetic variants in miRNA genes
    Authors:
    Magdalena Machowska, Paulina Galka-Marciniak, Piotr Kozlowski
    Academic press:
    Computational and Structural Biotechnology Journal (rok: 2022, tom: 20, strony: 6443-6457), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.csbj.2022.11.036 - link to the publication
  5. miRMut: Annotation of mutations in miRNA genes from human whole-exome or whole-genome sequencing
    Authors:
    Martyna O. Urbanek-Trzeciak, Piotr Kozlowski and Paulina Galka-Marciniak
    Academic press:
    STAR Protocols (rok: 2022, tom: 3, strony: 101023), Wydawca: Cell Press
    Status:
    Published
    DOI:
    10.1016/j.xpro.2021.101023 - link to the publication
  6. Mutations in the miR-142 gene are not common in myeloproliferative neoplasms
    Authors:
    Paulina Galka-Marciniak, Zuzanna Kanduła, Adrian Tire, Wladysław Wegorek , Karolina GwozdzBak , Luiza Handschuh, Maciej Giefing , Krzysztof Lewandowski , Piotr Kozlowski
    Academic press:
    Scientific Reports (rok: 2022, tom: 12, strony: 10924), Wydawca: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/s41598-022-15162-1 - link to the publication

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