Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Strategies to increase the performance of skeletal muscles and brown adipose tissue to combat obesity and related diseases

2020/38/E/NZ4/00314

Keywords:

adipose tissue adipocytes muscles metabolism obesity diabetes dynapenia sarcopenia ERK3 MK5

Descriptors:

  • NZ4_11: Metabolism
  • NZ4_2: Physiology
  • NZ3_1: Cell biology

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Instytut Biologii Doświadczalnej im. Marcelego Nenckiego Polskiej Akademii Nauk

woj.

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Grzegorz Piotr Sumara 

Number of co-investigators in the project: 5

Call: SONATA BIS 10 - announced on 2020-07-29

Amount awarded: 3 643 400 PLN

Project start date (Y-m-d): 2021-07-01

Project end date (Y-m-d): 2026-06-30

Project duration:: 60 months (the same as in the proposal)

Project status: Pending project

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (5)
  1. When fat meets the gut-focus on intestinal lipid handling in metabolic health and disease
    Authors:
    Magdalena Wit, Jonathan Trujillo-Viera, Akim Strohmeyer, Martin Klingenspor, Mohammed Hankir, Grzegorz Sumara
    Academic press:
    EMBO Molecular Medicine (rok: 2022, tom: 14, strony: e14742), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.15252/emmm.202114742 - link to the publication
  2. When fat meets the gut-focus on intestinal lipid handling in metabolic health and disease
    Authors:
    Magdalena Wit, Jonathan Trujillo-Viera, Akim Strohmeyer, Martin Klingenspor, Mohammed Hankir, Grzegorz Sumara
    Academic press:
    EMBO Molecular Medicine (rok: 2022, tom: 14, strony: e14742), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.15252/emmm.202114742 - link to the publication
  3. Targeting ERK3/MK5 complex for treatment of obesity and diabetes
    Authors:
    Angel Loza-Valdes, Rabih El-Merahbi, Toufic Kassouf, Agnieszka Demczuk, Saskia Reuter, Jonathan Trujillo Viera, Till Karwen, Minhe Noh, Mona C. Löffler, Rafael Romero-Becerra, Jorge L. Torres, Miguel Marcos, Guadalupe Sabio, Urszula Wojda, Grzegorz Sumara
    Academic press:
    Biochemical and Biophysical Research Communications (rok: 2022, tom: 612, strony: 119-125), Wydawca: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.bbrc.2022.04.070 - link to the publication
  4. Triazolo[4,5-d]pyrimidin-5-amines based ERK3 inhibitors fail to demonstrate selective effects on adipocyte function
    Authors:
    Andrei Belykh, Izabela Hawro, Katarzyna Kolczyńska-Matysiak, Angel Loza-Valdes, Adam Mieczkowski, Grzegorz Sumara
    Academic press:
    Archives of Biochemistry and Biophysics (rok: 2023, tom: 751, strony: 109825), Wydawca: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.abb.2023.109825 - link to the publication
  5. Targeting ERK3/MK5 complex for treatment of obesity and diabetes
    Authors:
    Angel Loza-Valdes, Rabih El-Merahbi, Toufic Kassouf, Agnieszka Demczuk, Saskia Reuter, Jonathan Trujillo Viera, Till Karwen, Minhe Noh, Mona C. Löffler, Rafael Romero-Becerra, Jorge L. Torres, Miguel Marcos, Guadalupe Sabio, Urszula Wojda, Grzegorz Sumara
    Academic press:
    Biochemical and Biophysical Research Communications (rok: 2022, tom: 612, strony: 119-125), Wydawca: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.bbrc.2022.04.070 - link to the publication

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