Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Astrocytes-regulated oligomerization state of fructose bisphosphatase 2 (FBP2) in neurons as a basic factor regulating memory formation and mitochondria function

2020/37/B/NZ4/00808

Keywords:

Long Term Potentiation (LTP) protein-protein interactions Cryogenic Electron Microscopy (CryoEM) glycogen lactate GSK3b CAMKII animal model of memory formation

Descriptors:

  • NZ4_7: Neurophysiology
  • NZ4_11: Metabolism
  • NZ1_4: Structural biology

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Uniwersytet Wrocławski, Wydział Nauk Biologicznych

woj.

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Dariusz Stanisław Rakus 

Number of co-investigators in the project: 14

Call: OPUS 19 - announced on 2020-03-16

Amount awarded: 2 052 600 PLN

Project start date (Y-m-d): 2021-08-25

Project end date (Y-m-d): 2025-08-24

Project duration:: 48 months (the same as in the proposal)

Project status: Pending project

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (5)
  1. Absolute Proteome Analysis of Hippocampus, Cortex and Cerebellum in Aged and Young Mice Reveals Changes in Energy Metabolism.
    Authors:
    Gostomska-Pampuch K, Drulis-Fajdasz D, Gizak A, Wiśniewski JR, Rakus D.
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22(12), strony: 6188-6204), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22126188 - link to the publication
  2. Quantitative Proteomics Reveals Significant Differences between Mouse Brain Formations in Expression of Proteins Involved in Neuronal Plasticity during Aging
    Authors:
    Drulis-Fajdasz D, Gostomska-Pampuch K, Duda P, Wiśniewski JR, Rakus D.
    Academic press:
    Cells (rok: 2021, tom: 10(8), strony: 2021-2047), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells10082021 - link to the publication
  3. Glycogen phosphorylase inhibition improves cognitive function of aged mice
    Authors:
    Drulis-Fajdasz D, Krzystyniak A, Pytyś A, Gostomska-Pampuch K, Pudełko-Malik N, Wiśniewski JŁ, Młynarz P, Miazek A, Wójtowicz T, Włodarczyk J, Duś-Szachniewicz K, Kizak A, Wiśniewski JR, Rakus D
    Academic press:
    Aging Cell (rok: 2023, tom: 22,9, strony: e13928), Wydawca: Wiley-Blackwell Publishing Ltd
    Status:
    Published
    DOI:
    10.1111/acel.13928 - link to the publication
  4. Quantitative Proteomics Reveals Significant Differences between Mouse Brain Formations in Expression of Proteins Involved in Neuronal Plasticity during Aging
    Authors:
    Drulis-Fajdasz D, Gostomska-Pampuch K, Duda P, Wiśniewski JR, Rakus D.
    Academic press:
    Cells (rok: 2021, tom: 10(8), strony: 2021-2047), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells10082021 - link to the publication
  5. Absolute Proteome Analysis of Hippocampus, Cortex and Cerebellum in Aged and Young Mice Reveals Changes in Energy Metabolism.
    Authors:
    Gostomska-Pampuch K, Drulis-Fajdasz D, Gizak A, Wiśniewski JR, Rakus D.
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22(12), strony: 6188-6204), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22126188 - link to the publication

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