Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Understanding of human insulin maturation for cell and gene therapy in diabetes

2020/37/B/NZ3/01917

Keywords:

proinsulin folding insulin IGF2 pancreas beta-cells stem cell differentiation diabetes mice gene editing with CRISPR-Cas9

Descriptors:

  • NZ3_008:
  • NZ3_002:
  • NZ3_012:

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Biologii

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Małgorzata Borowiak 

Number of co-investigators in the project: 6

Call: OPUS 19 - announced on 2020-03-16

Amount awarded: 2 161 891 PLN

Project start date (Y-m-d): 2021-02-01

Project end date (Y-m-d): 2026-10-31

Project duration:: 69 months (the same as in the proposal)

Project status: Pending project

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (7)
  1. Diabetes and SARS-CoV-2-Is There a Mutual Connection?
    Authors:
    Jedrzejak AP, Urbaniak EK, Wasko JA, Ziojla N, Borowiak M
    Academic press:
    Frontiers in Cell and Developmental Biology (rok: 2022, tom: 10, strony: 913305), Wydawca: Frontiers Media S.A.
    Status:
    Published
    DOI:
    10.3389/fcell.2022.913305 - link to the publication
  2. ETVs dictate hPSC differentiation by tuning biophysical properties
    Authors:
    Natalia M. Ziojła, Magdalena Socha, M. Cecilia Guerra, Dorota Kizewska, Katarzyna Blaszczyk, Edyta Urbaniak, Sara Henry, Malgorzata Grabowska , Kathy K. Niakan, Aryeh Warmflash, Malgorzata Borowiak
    Academic press:
    Nature Communications (rok: 2025, tom: 16, strony: 56591-96), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1038/s41467-025-56591-6 - link to the publication
  3. Oxidative stress and GPX2 control pancreatic vs. non-pancreatic cell fate in human endoderm
    Authors:
    Joanna Szpotkowska, Wojciech J Szlachcic, Katarzyna Blaszczyk, Maja Baginska, Magdalena Socha, Malgorzata Borowiak
    Academic press:
    Nature Communications (rok: 2026, tom: 17(1)., strony: 1407), Wydawca: Nature
    Status:
    Published
    DOI:
    10.1038/s41467-025-68145-x - link to the publication
  4. Allelic bias contributes to heterogeneous phenotypes of NK cell deficiency
    Authors:
    Seungmae Seo, Yong-Oon Ahn, Sagar L Patil, Jacqueline Armetta, Madrikha D Saturne, Everardo Hegewisch-Solloa, Nicole C Guilz , Achchhe Patel, Barbara Corneo, Malgorzata Borowiak , Emily M Mace
    Academic press:
    Cell Reports (rok: 2025, tom: 44, strony: 8), Wydawca: Cell Reports
    Status:
    Published
    DOI:
    10.1016/j.celrep.2025.116102 - link to the publication
  5. SPOCK2 controls the proliferation and function of immature pancreatic β-cells through MMP2
    Authors:
    Katarzyna Blaszczyk , Anna P. Jedrzejak, Natalia Ziojla, Ekaterina Shcheglova, Karolina Szarafin, Artur Jankowski, Christine A. Beamish , Jolanta Chmielowiec, Omaima M. Sabek , Ashok Balasubramanyam, Sanjeet Patel and Malgorzata Borowiak
    Academic press:
    Experimental and Molecular Medicine (rok: 2025, tom: 57(1), strony: 131-150), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1038/s12276-024-01380-2 - link to the publication
  6. Deep into the niche: Deciphering local endoderm-microenvironment interactions in development, homeostasis, and disease of pancreas and intestine
    Authors:
    Szlachcic WJ, Letai KC, Scavuzzo MA, Borowiak M
    Academic press:
    BioEssays (rok: 2023, tom: 45(4), strony: e2200186), Wydawca: Wiley Periodicals LLC
    Status:
    Published
    DOI:
    10.1002/bies.202200186 - link to the publication
  7. Pancreatic organogenesis mapped through space and time
    Authors:
    Marissa A Scavuzzo , Wojciech J Szlachcic , Matthew C Hill, Natalia M Ziojla, Jessica Teaw, Jeffrey C Carlson, Jonathan Tiessen, Jolanta Chmielowiec, James F Martin, Malgorzata Borowiak
    Academic press:
    Experimental Molecular Medicine (rok: 2025, tom: 57(1), strony: 204-220), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1038/s12276-024-01384-y - link to the publication

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