Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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(TNT-CVD), Trimethylamine as a Nitrogenous Toxin in Cardiovascular Diseases.

2020/37/B/NZ5/00366

Keywords:

cardiovascular diseases hypertension heart failure trimethylamine toxin nitrogen cycle in organism,

Descriptors:

  • NZ5_1: Etiology of human diseases
  • NZ5_3: Pathogenesis of human diseases
  • NZ4_4: Pathophysiology

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Warszawski Uniwersytet Medyczny

woj.

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Marcin Ufnal 

Number of co-investigators in the project: 6

Call: OPUS 19 - announced on 2020-03-16

Amount awarded: 1 998 000 PLN

Project start date (Y-m-d): 2021-01-19

Project end date (Y-m-d): 2025-07-18

Project duration:: 54 months (the same as in the proposal)

Project status: Pending project

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (24)
  1. Urinary excretion of asymmetric (ADMA) and symmetric (SDMA) dimethylarginine is positively related to nitric oxide level in tissues of normotensive and hypertensive rats
    Authors:
    Dominika Szlęzak, Marcin Ufnal, Adrian Drapała, Emilia Samborowska, Maria Wróbel
    Academic press:
    Amino Acids (rok: 2023, tom: 111, strony: 45668), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00726-023-03246-9 - link to the publication
  2. Mice, rats, and guinea pigs differ in FMOs expression and tissue concentration of TMAO, a gut bacteria-derived biomarker of cardiovascular and metabolic diseases
    Authors:
    Klaudia M Maksymiuk , Mateusz Szudzik , Emilia Samborowska, Dawid Chabowski, Marek Konop, Marcin Ufnal
    Academic press:
    PlosONe (rok: 2024, tom: 19, strony: e0297474), Wydawca: PlosONe
    Status:
    Published
    DOI:
    10.1371/journal.pone.02974744 - link to the publication
  3. Mice, rats, and guinea pigs differ in FMOs expression and tissue concentration of TMAO, a gut bacteria-derived biomarker of cardiovascular and metabolic diseases
    Authors:
    Klaudia M Maksymiuk , Mateusz Szudzik , Emilia Samborowska, Dawid Chabowski, Marek Konop, Marcin Ufnal
    Academic press:
    PlosONe (rok: 2024, tom: 19, strony: e0297474), Wydawca: PlosONe
    Status:
    Published
    DOI:
    10.1371/journal.pone.02974744 - link to the publication
  4. Symmetric Dimethylarginine is Altered in Patients After Myocardial Infarction and Predicts Adverse Outcomes
    Authors:
    Aleksandra Gąsecka 1 , Piotr Szwed 1 , Karolina Jasińska 1 , Oliwia Fidali 1 , Aleksandra Kłębukowska 1 , Ceren Eyileten 2 , Marek Postula 2 , Łukasz Szarpak 3 4 , Tomasz Mazurek 1 , Grzegorz Opolski 1 , Krzysztof J Filipiak 1 , Marcin Ufnal 5
    Academic press:
    Journal of Inflammation Research (rok: 2022, tom: 10, strony: 14:3797-3808), Wydawca: DOVE
    Status:
    Published
    DOI:
    10.2147/JIR.S316078 - link to the publication
  5. Microbiome-Derived Trimethylamine N-Oxide (TMAO) as a Multifaceted Biomarker in Cardiovascular Disease: Challenges and Opportunities
    Authors:
    Kinga Jaworska, Wojciech Kopacz, Mateusz Koper, Marcin Ufnal
    Academic press:
    International Journal of Molecular Sciences (rok: 2024, tom: 25, strony: 45674), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms252312511 - link to the publication
  6. Plasma concentration of TMAO is an independent predictor of adverse outcomes in patients after acute myocardial infarction
    Authors:
    Aleksandra Gąsecka, Oliwia Fidali, Aleksandra Kłębukowska, Karolina Jasińska-Gniadzik, Piotr Szwed, Karolina Witkowska, Ceren Eyileten, Marek Postuła, Marcin Grabowski, Krzysztof J. Filipiak, Marcin Ufnal
    Academic press:
    Advances in Interventional Cardiology (rok: 2022, tom: 18, strony: 45666), Wydawca: Termedia Publishing House
    Status:
    Published
    DOI:
    10.5114/aic.2022.123884 - link to the publication
  7. Enalapril Diminishes the Diabetes‐Induced Changes in Intestinal Morphology, Intestinal RAS and Blood SCFA Concentration in Rats
    Authors:
    Kinga Jaworska, Wojciech Kopacz, Mateusz Koper, Mateusz Szudzik, Marta Gawryś‐Kopczyńska, Marek Konop, Tomasz Hutsch, Dawid Chabowski and Marcin Ufnal
    Academic press:
    International Journal of Molecular Sciences (rok: 2022, tom: 23, strony: 45669), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms23116060 - link to the publication
  8. Urinary excretion of asymmetric (ADMA) and symmetric (SDMA) dimethylarginine is positively related to nitric oxide level in tissues of normotensive and hypertensive rats
    Authors:
    Dominika Szlęzak, Marcin Ufnal, Adrian Drapała, Emilia Samborowska, Maria Wróbel
    Academic press:
    Amino Acids (rok: 2023, tom: 111, strony: 45668), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00726-023-03246-9 - link to the publication
  9. Symmetric Dimethylarginine is Altered in Patients After Myocardial Infarction and Predicts Adverse Outcomes
    Authors:
    Aleksandra Gąsecka 1 , Piotr Szwed 1 , Karolina Jasińska 1 , Oliwia Fidali 1 , Aleksandra Kłębukowska 1 , Ceren Eyileten 2 , Marek Postula 2 , Łukasz Szarpak 3 4 , Tomasz Mazurek 1 , Grzegorz Opolski 1 , Krzysztof J Filipiak 1 , Marcin Ufnal 5
    Academic press:
    Journal of Inflammation Research (rok: 2022, tom: 10, strony: 14:3797-3808), Wydawca: DOVE
    Status:
    Published
    DOI:
    10.2147/JIR.S316078 - link to the publication
  10. Spontaneously hypertensive rats exhibit increased liver flavin monooxygenase expression and elevated plasma TMAO levels compared to normotensive and Ang II-dependent hypertensive rats
    Authors:
    Marta Gawryś-Kopczyńska, Mateusz Szudzik, Emilia Samborowska, Marek Konop, Dawid Chabowski, Maksymilian Onyszkiewicz, Marcin Ufnal
    Academic press:
    Frontiers in Physiology (rok: 2024, tom: 15:1340166., strony: 45666), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fphys.2024.1340166 - link to the publication
  11. Trimethylamine, a gut bacteria metabolite and air pollutant, increases blood pressure and markers of kidney damage including proteinuria and KIM‑1 in rats.
    Authors:
    Klaudia M. Maksymiuk, Mateusz Szudzik, Marta Gawryś‑Kopczyńska, Maksymilian Onyszkiewicz, Emilia Samborowska, Izabella Mogilnicka and Marcin Ufnal
    Academic press:
    Journal of Translational Medicine (rok: 2022, tom: 20, strony: 45671), Wydawca: BMC
    Status:
    Published
    DOI:
    10.1186/s12967-022-03687-y - link to the publication
  12. Symmetric Dimethylarginine is Altered in Patients After Myocardial Infarction and Predicts Adverse Outcomes
    Authors:
    Aleksandra Gąsecka 1 , Piotr Szwed 1 , Karolina Jasińska 1 , Oliwia Fidali 1 , Aleksandra Kłębukowska 1 , Ceren Eyileten 2 , Marek Postula 2 , Łukasz Szarpak 3 4 , Tomasz Mazurek 1 , Grzegorz Opolski 1 , Krzysztof J Filipiak 1 , Marcin Ufnal 5
    Academic press:
    Journal of Inflammation Research (rok: 2022, tom: 10, strony: 14:3797-3808), Wydawca: DOVE
    Status:
    Published
    DOI:
    10.2147/JIR.S316078 - link to the publication
  13. Plasma concentration of TMAO is an independent predictor of adverse outcomes in patients after acute myocardial infarction
    Authors:
    Aleksandra Gąsecka, Oliwia Fidali, Aleksandra Kłębukowska, Karolina Jasińska-Gniadzik, Piotr Szwed, Karolina Witkowska, Ceren Eyileten, Marek Postuła, Marcin Grabowski, Krzysztof J. Filipiak, Marcin Ufnal
    Academic press:
    Advances in Interventional Cardiology (rok: 2022, tom: 18, strony: 45666), Wydawca: Termedia Publishing House
    Status:
    Published
    DOI:
    10.5114/aic.2022.123884 - link to the publication
  14. Trimethylamine, a gut bacteria metabolite, and air pollutant, elevates blood pressure and increases proteinuria and KIM-1 in rats.
    Authors:
    MVD Klaudia M Maksymiuk1; PhD Mateusz Szudzik1; Marta Gawryś-Kopczyńska1; MD, PhD Marcin Ufnal1
    Academic press:
    Kidney International
    Status:
    Submitted
  15. Enalapril Diminishes the Diabetes‐Induced Changes in Intestinal Morphology, Intestinal RAS and Blood SCFA Concentration in Rats
    Authors:
    Kinga Jaworska, Wojciech Kopacz, Mateusz Koper, Mateusz Szudzik, Marta Gawryś‐Kopczyńska, Marek Konop, Tomasz Hutsch, Dawid Chabowski and Marcin Ufnal
    Academic press:
    International Journal of Molecular Sciences (rok: 2022, tom: 23, strony: 45669), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms23116060 - link to the publication
  16. Urinary excretion of asymmetric (ADMA) and symmetric (SDMA) dimethylarginine is positively related to nitric oxide level in tissues of normotensive and hypertensive rats
    Authors:
    Dominika Szlęzak, Marcin Ufnal, Adrian Drapała, Emilia Samborowska, Maria Wróbel
    Academic press:
    Amino Acids (rok: 2023, tom: 111, strony: 45668), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00726-023-03246-9 - link to the publication
  17. Deoxycholic Acid, a Secondary Bile Acid, Increases Cardiac Output and Blood Pressure in Rats
    Authors:
    Artur Nowiński, Dawid Chabowski , Joanna Giebułtowicz, Marta Aleksandrowicz, Marcin Ufnal
    Academic press:
    Nutrients (rok: 2023, tom: 21, strony: 45667), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/nu16010032 - link to the publication
  18. Trimethylamine, a gut bacteria metabolite and air pollutant, increases blood pressure and markers of kidney damage including proteinuria and KIM‑1 in rats.
    Authors:
    Klaudia M. Maksymiuk, Mateusz Szudzik, Marta Gawryś‑Kopczyńska, Maksymilian Onyszkiewicz, Emilia Samborowska, Izabella Mogilnicka and Marcin Ufnal
    Academic press:
    Journal of Translational Medicine (rok: 2022, tom: 20, strony: 45671), Wydawca: BMC
    Status:
    Published
    DOI:
    10.1186/s12967-022-03687-y - link to the publication
  19. Deoxycholic Acid, a Secondary Bile Acid, Increases Cardiac Output and Blood Pressure in Rats
    Authors:
    Artur Nowiński, Dawid Chabowski , Joanna Giebułtowicz, Marta Aleksandrowicz, Marcin Ufnal
    Academic press:
    Nutrients (rok: 2023, tom: 21, strony: 45667), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/nu16010032 - link to the publication
  20. Normal caloric intake with high-fat diet induces metabolic dysfunction-associated steatotic liver disease and dyslipidemia without obesity in rats
    Authors:
    Mateusz Szudzik, Tomasz Hutsch, Dawid Chabowski, Mikołaj Zajdel, Marcin Ufnal
    Academic press:
    Scientific Reports (rok: 2024, tom: 14:22796, strony: 45667), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1038/s41598-024-74193-y - link to the publication
  21. Plasma concentration of TMAO is an independent predictor of adverse outcomes in patients after acute myocardial infarction
    Authors:
    Aleksandra Gąsecka, Oliwia Fidali, Aleksandra Kłębukowska, Karolina Jasińska-Gniadzik, Piotr Szwed, Karolina Witkowska, Ceren Eyileten, Marek Postuła, Marcin Grabowski, Krzysztof J. Filipiak, Marcin Ufnal
    Academic press:
    Advances in Interventional Cardiology (rok: 2022, tom: 18, strony: 45666), Wydawca: Termedia Publishing House
    Status:
    Published
    DOI:
    10.5114/aic.2022.123884 - link to the publication
  22. Enalapril Diminishes the Diabetes‐Induced Changes in Intestinal Morphology, Intestinal RAS and Blood SCFA Concentration in Rats
    Authors:
    Kinga Jaworska, Wojciech Kopacz, Mateusz Koper, Mateusz Szudzik, Marta Gawryś‐Kopczyńska, Marek Konop, Tomasz Hutsch, Dawid Chabowski and Marcin Ufnal
    Academic press:
    International Journal of Molecular Sciences (rok: 2022, tom: 23, strony: 45669), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms23116060 - link to the publication
  23. Trimethylamine, a gut bacteria metabolite and air pollutant, increases blood pressure and markers of kidney damage including proteinuria and KIM‑1 in rats.
    Authors:
    Klaudia M. Maksymiuk, Mateusz Szudzik, Marta Gawryś‑Kopczyńska, Maksymilian Onyszkiewicz, Emilia Samborowska, Izabella Mogilnicka and Marcin Ufnal
    Academic press:
    Journal of Translational Medicine (rok: 2022, tom: 20, strony: 45671), Wydawca: BMC
    Status:
    Published
    DOI:
    10.1186/s12967-022-03687-y - link to the publication
  24. Symmetric Dimethylarginine is Altered in Patients After Myocardial Infarction and Predicts Adverse Outcomes
    Authors:
    Aleksandra Gąsecka 1 , Piotr Szwed 1 , Karolina Jasińska 1 , Oliwia Fidali 1 , Aleksandra Kłębukowska 1 , Ceren Eyileten 2 , Marek Postula 2 , Łukasz Szarpak 3 4 , Tomasz Mazurek 1 , Grzegorz Opolski 1 , Krzysztof J Filipiak 1 , Marcin Ufnal 5
    Academic press:
    Journal of Inflammation Research (rok: 2022, tom: 10, strony: 14:3797-3808), Wydawca: DOVE
    Status:
    Published
    DOI:
    10.2147/JIR.S316078 - link to the publication

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