Projects funded by the NCN
Mitochondria, oxidative stress and Non Alcoholic Fatty Liver Disease development: a complex relationship
2020/36/T/NZ1/00004
Keywords:
NAFLD Western diet mitochondria reactive oxygen species
Descriptors:
- NZ1_2: Biochemistry
Panel:
NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology
Host institution :
Instytut Biologii Doświadczalnej im. Marcelego Nenckiego Polskiej Akademii Nauk
woj.
Principal investigator (from the host institution):
Number of co-investigators in the project: 1
Call: ETIUDA 8 - announced on 2019-12-16
Amount awarded: 106 416 PLN
Project start date (Y-m-d): 2020-10-01
Project end date (Y-m-d): 2021-09-30
Project duration:: 12 months (the same as in the proposal)
Project status: Project settled
Project description
Download the project description in a pdf file
Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Information in the final report
- Publication in academic press/journals (4)
- Mitochondria, oxidative stress and nonalcoholic fatty liver disease: A complex relationshipAuthors:Agnieszka Karkucinska-Wieckowska, Ines C. M. Simoes, Piotr Kalinowski, Magdalena Lebiedzinska-Arciszewska, Krzysztof Zieniewicz, Piotr Milkiewicz, Magdalena Górska-Ponikowska, Paolo Pinton, Afshan N. Malik, Marcin Krawczyk, Paulo J. Oliveira, Mariusz R. WieckowskiAcademic press:European Journal of Clinical Investigation (rok: 2021, tom: 52(3), strony: e13622), Wydawca: John Wiley & Sons LtdStatus:PublishedDOI:10.1111/eci.13622 - link to the publication
- Mitochondria-targeted anti-oxidant AntiOxCIN4 improved liver steatosis in Western diet-fed mice by preventing lipid accumulation due to upregulation of fatty acid oxidation, quality control mechanism and antioxidant defense systemsAuthors:Ricardo Amorim, Ines C.M. Simoes, Jose Teixeira, Fernando Cagide, Yaiza Potes, Pedro Soares, Adriana Carvalho, Ludgero C. Tavares, Sofia Benfeito, Susana P. Pereira, Rui F. Simoes, Agnieszka Karkucinska-Wieckowska, Ivan Viegas, Sylwia Szymanska, Michal Dabrowski, Justyna Janikiewicz, Teresa Cunha-Oliveira, Agnieszka Dobrzyn, John G. Jones, Fernanda Borges, Mariusz R. Wieckowski, Paulo J. OliveiraAcademic press:Redox Biology (rok: 2022, tom: 55, strony: 102400), Wydawca: ElsevierStatus:PublishedDOI:10.1016/j.redox.2022.102400 - link to the publication
- The Alterations of Mitochondrial Function during NAFLD Progression—An Independent Effect of Mitochondrial ROS ProductionAuthors:Inês C. M. Simões, Ricardo Amorim, José Teixeira, Agnieszka Karkucinska‐Wieckowska, Adriana Carvalho, Susana P. Pereira, Rui F. Simões, Sylwia Szymanska, Michał Dąbrowski, Justyna Janikiewicz, Agnieszka Dobrzyń, Paulo J. Oliveira, Yaiza Potes and Mariusz R. WieckowskiAcademic press:International Journal of Molecular Sciences (rok: 2021, tom: 22(13), strony: 6848), Wydawca: MDPIStatus:PublishedDOI:10.3390/ijms22136848 - link to the publication
- MARC1 p.A165T variant is associated with decreased markers of liver injury and enhanced antioxidant capacity in autoimmune hepatitisAuthors:Maciej K. Janik, Wiktor Smyk, Beata Kruk, Benedykt Szczepankiewicz, Barbara Górnicka, Magdalena Lebiedzińska-Arciszewska, Yaiza Potes, Ines C. M. Simoes, Susanne N. Weber, Frank Lammert, Mariusz R. Wieckowski, Piotr Milkiewicz & Marcin KrawczykAcademic press:Scientific Reports (rok: 2021, tom: 11, strony: 24407), Wydawca: Springer NatureStatus:PublishedDOI:10.1038/s41598-021-03521-3 - link to the publication