Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

Delete all

Deciphering the effect of PGC1a on mitochondrial biogenesis and neural differentiation during early development of human cerebral organoids

2019/35/B/NZ3/04383

Keywords:

cerebral organoids mitochondrial biogenesis reporter cell line PGC-1 alpha optogenetics

Descriptors:

  • NZ3_8: Stem cell biology
  • NZ3_5: Molecular neurobiology
  • NZ3_9: Organogenesis

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego Polskiej Akademii Nauk

woj.

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Leonora Maria Bużańska 

Number of co-investigators in the project: 5

Call: OPUS 18 - announced on 2019-09-16

Amount awarded: 2 394 840 PLN

Project start date (Y-m-d): 2020-09-30

Project end date (Y-m-d): 2025-09-29

Project duration:: 60 months (the same as in the proposal)

Project status: Pending project

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (11)
  • Articles in post-conference publications (8)
  1. Covering the Role of PGC-1α in the Nervous System
    Authors:
    Kuczynska Z., Metin E., Liput M., Buzanska L.
    Academic press:
    Cells (rok: 2022, tom: 11, strony: 111), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells11010111 - link to the publication
  2. Regenerative Neurology and Regenerative Cardiology: Shared Hurdles and Achievements
    Authors:
    Mitrečić D, Hribljan V, Jagečić D, Isaković J, Lamberto F, Horánszky A, Zana M, Foldes G, Zavan B, Pivoriūnas A, Martinez S, Mazzini L, Radenovic L, Milasin J, Chachques JC, Buzanska L, Song MS, Dinnyés A.
    Academic press:
    International Journal of Molecular Sciences (rok: 2022, tom: 13;23(2):855, strony: 45677), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms23020855 - link to the publication
  3. Tools and approaches for analyzing the role of mitochondria in health, development and disease using human cerebral organoids
    Authors:
    Liput M., Kuczynska Z., Zayat V., Ahluwalia A., Buzanska L.
    Academic press:
    Developmental neurobiology (rok: 2021, tom: 81(5), strony: 591-607), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/dneu.22818 - link to the publication
  4. Regenerative Neurology and Regenerative Cardiology: Shared Hurdles and Achievements
    Authors:
    Mitrečić D, Hribljan V, Jagečić D, Isaković J, Lamberto F, Horánszky A, Zana M, Foldes G, Zavan B, Pivoriūnas A, Martinez S, Mazzini L, Radenovic L, Milasin J, Chachques JC, Buzanska L, Song MS, Dinnyés A.
    Academic press:
    International Journal of Molecular Sciences (rok: 2022, tom: 13;23(2):855, strony: 45677), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms23020855 - link to the publication
  5. Regenerative Neurology and Regenerative Cardiology: Shared Hurdles and Achievements
    Authors:
    Mitrečić D, Hribljan V, Jagečić D, Isaković J, Lamberto F, Horánszky A, Zana M, Foldes G, Zavan B, Pivoriūnas A, Martinez S, Mazzini L, Radenovic L, Milasin J, Chachques JC, Buzanska L, Song MS, Dinnyés A.
    Academic press:
    International Journal of Molecular Sciences (rok: 2022, tom: 13;23(2):855, strony: 45677), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms23020855 - link to the publication
  6. Covering the Role of PGC-1α in the Nervous System
    Authors:
    Kuczynska Z., Metin E., Liput M., Buzanska L.
    Academic press:
    Cells (rok: 2022, tom: 11, strony: 111), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells11010111 - link to the publication
  7. Tools and approaches for analyzing the role of mitochondria in health, development and disease using human cerebral organoids
    Authors:
    Liput M., Kuczynska Z., Zayat V., Ahluwalia A., Buzanska L.
    Academic press:
    Developmental neurobiology (rok: 2021, tom: 81(5), strony: 591-607), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/dneu.22818 - link to the publication
  8. Covering the Role of PGC-1α in the Nervous System
    Authors:
    Kuczynska Z., Metin E., Liput M., Buzanska L.
    Academic press:
    Cells (rok: 2022, tom: 11, strony: 111), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells11010111 - link to the publication
  9. Tools and approaches for analyzing the role of mitochondria in health, development and disease using human cerebral organoids
    Authors:
    Liput M., Kuczynska Z., Zayat V., Ahluwalia A., Buzanska L.
    Academic press:
    Developmental neurobiology (rok: 2021, tom: 81(5), strony: 591-607), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/dneu.22818 - link to the publication
  10. Tools and approaches for analyzing the role of mitochondria in health, development and disease using human cerebral organoids
    Authors:
    Liput M., Kuczynska Z., Zayat V., Ahluwalia A., Buzanska L.
    Academic press:
    Developmental neurobiology (rok: 2021, tom: 81(5), strony: 591-607), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/dneu.22818 - link to the publication
  11. Covering the Role of PGC-1α in the Nervous System
    Authors:
    Kuczynska Z., Metin E., Liput M., Buzanska L.
    Academic press:
    Cells (rok: 2022, tom: 11, strony: 111), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells11010111 - link to the publication
  1. The effect of mitochondrial biogenesis induction through A7NACHR agonists on the cell fate at the early developmental stage of human cortical organoid
    Authors:
    Metin E, Siek Z, Kuczynska Z, Liput M, Buzanska L
    Conference:
    Tissue Engineering and Regenerative Medicine International Society (TERMIS).Program and Abstract (rok: 2023, tom: Tissue Engineering and Regenerative Medicine International Society (TERMIS), strony: 1648-1649), Wydawca: Tissue Engineering Part A, Mary Ann Liebert, Inc
    Data:
    konferencja 28.06-01.07.2022
    Status:
    Published
    DOI:
    10.1089/ten.tea.2023.29046.abstracts - link to the publication
  2. Physiological normoxia influence neural cell fate through changes of mitochondrial dynamics and glycolysis/OSPHOS switch in human brain organoid model.
    Authors:
    Liput M, Kuczynska Z, Fabbri R, Magliaro C, Ahluwalia A, Buzanska L
    Conference:
    Tissue Engineering and Regenerative Medicine International Society (TERMIS).Program and Abstracts (rok: 2023, tom: Tissue Engineering and Regenerative Medicine International Society (TERMIS), strony: 928-929), Wydawca: Tissue Engineering Part A.Mary Ann Liebert, Inc.
    Data:
    konferencja 28.06-01.07.2022
    Status:
    Published
    DOI:
    10.1089/ten.tea.2023.29046.abstracts - link to the publication
  3. Streamlined CRISPR/Cas9-mediated generation of dual-reporter PGC1α human induced pluripotent stem cell line
    Authors:
    Leszczyński P, Kuczyńska Z, Liput M, Duchnowska A, Bużańska L
    Conference:
    Abstracts from the Conference (rok: 2023, tom: Neuropatologia 2023, strony: 468), Wydawca: Termedia
    Data:
    konferencja 17-18 November 2023
    Status:
    Published
    DOI:
    link to the publication
  4. PGC-1α activator ZLN005 enhances neurogenesis during the early stage of human dorsal forebrain organoid development
    Authors:
    Kuczynska Z., Leszczynski P., Metin E., Liput M., Buzanska L
    Conference:
    Abstracts from Conference (rok: 2023, tom: Neuropatologia 2023, strony: 466-467), Wydawca: Termedia
    Data:
    konferencja 17-18 November 2023
    Status:
    Published
    DOI:
    link to the publication
  5. Streamlined CRISPR/Cas9-mediated generation of dual-reporter PGC1α human induced pluripotent stem cell line
    Authors:
    Leszczyński P, Kuczyńska Z, Liput M, Duchnowska A, Bużańska L
    Conference:
    Abstracts from the Conference (rok: 2023, tom: Neuropatologia 2023, strony: 468), Wydawca: Termedia
    Data:
    konferencja 17-18 November 2023
    Status:
    Published
    DOI:
    link to the publication
  6. The effect of mitochondrial biogenesis induction through A7NACHR agonists on the cell fate at the early developmental stage of human cortical organoid
    Authors:
    Metin E, Siek Z, Kuczynska Z, Liput M, Buzanska L
    Conference:
    Tissue Engineering and Regenerative Medicine International Society (TERMIS).Program and Abstract (rok: 2023, tom: Tissue Engineering and Regenerative Medicine International Society (TERMIS), strony: 1648-1649), Wydawca: Tissue Engineering Part A, Mary Ann Liebert, Inc
    Data:
    konferencja 28.06-01.07.2022
    Status:
    Published
    DOI:
    10.1089/ten.tea.2023.29046.abstracts - link to the publication
  7. Physiological normoxia influence neural cell fate through changes of mitochondrial dynamics and glycolysis/OSPHOS switch in human brain organoid model.
    Authors:
    Liput M, Kuczynska Z, Fabbri R, Magliaro C, Ahluwalia A, Buzanska L
    Conference:
    Tissue Engineering and Regenerative Medicine International Society (TERMIS).Program and Abstracts (rok: 2023, tom: Tissue Engineering and Regenerative Medicine International Society (TERMIS), strony: 928-929), Wydawca: Tissue Engineering Part A.Mary Ann Liebert, Inc.
    Data:
    konferencja 28.06-01.07.2022
    Status:
    Published
    DOI:
    10.1089/ten.tea.2023.29046.abstracts - link to the publication
  8. PGC-1α activator ZLN005 enhances neurogenesis during the early stage of human dorsal forebrain organoid development
    Authors:
    Kuczynska Z., Leszczynski P., Metin E., Liput M., Buzanska L
    Conference:
    Abstracts from Conference (rok: 2023, tom: Neuropatologia 2023, strony: 466-467), Wydawca: Termedia
    Data:
    konferencja 17-18 November 2023
    Status:
    Published
    DOI:
    link to the publication

O Narodowym Centrum Nauki

Finansowanie nauki

Współpraca zagraniczna

Centrum prasowe

Deklaracja dostępności
Przetwarzanie danych osobowych
Polityka cookies

Partnerzy