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Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Novel therapy for pulmonary hypertension with dual mechanism of action: Myo-inositol trispyrophosphate targeting both pulmonary vessels and the heart

2019/35/B/NZ5/04432

Keywords:

pulmonary hypertension,

Descriptors:

  • NZ5_3: Pathogenesis of human diseases

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Centrum Medyczne Kształcenia Podyplomowego

woj.

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Michał Maria Mączewski 

Number of co-investigators in the project: 8

Call: OPUS 18 - announced on 2019-09-16

Amount awarded: 2 050 716 PLN

Project start date (Y-m-d): 2020-07-20

Project end date (Y-m-d): 2024-07-19

Project duration:: 48 months (the same as in the proposal)

Project status: Project completed

Project description

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Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (7)
  1. Right ventricular myocardial oxygen tension is reduced in monocrotaline-induced pulmonary hypertension in the rat and restored by myo-inositol trispyrophosphate
    Authors:
    Marta Oknińska, Zuzanna Zambrowska, Karolina Zajda, Aleksandra Paterek, Klaudia Brodaczewska, Urszula Mackiewicz, Cezary Szczylik, Adam Torbicki, Claudine Kieda & Michał Mączewski
    Academic press:
    Scientific Reports (rok: 2021, tom: 11, strony: 18002), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1038/s41598-021-97470-6 - link to the publication
  2. Right ventricular myocardial oxygen tension is reduced in monocrotaline-induced pulmonary hypertension in the rat and restored by myo-inositol trispyrophosphate
    Authors:
    Marta Oknińska, Zuzanna Zambrowska, Karolina Zajda, Aleksandra Paterek, Klaudia Brodaczewska, Urszula Mackiewicz, Cezary Szczylik, Adam Torbicki, Claudine Kieda & Michał Mączewski
    Academic press:
    Scientific Reports (rok: 2021, tom: 11, strony: 18002), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1038/s41598-021-97470-6 - link to the publication
  3. New potential treatment for cardiovascular disease through modulation of hemoglobin oxygen binding curve: Myo-inositol trispyrophosphate (ITPP), from cancer to cardiovascular disease
    Authors:
    Marta Oknińska, Urszula Mackiewicz, Karolina Zajda, Claudine Kieda, Michał Mączewski
    Academic press:
    Biomedicine & Pharmacotherapy (rok: 2022, tom: 154, strony: 113544), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.biopha.2022.113544 - link to the publication
  4. Role of oxygen starvation in right ventricular decompensation/failure in pulmonary arterial hypertension
    Authors:
    Marta Oknińska, Karolina Zajda, Zuzanna Zambrowska, Małgorzata Grzanka, Aleksandra Paterek, Urszula Mackiewicz, Cezary Szczylik, Marcin Kurzyna, Agnieszka Piekiełko-Witkowska, Adam Torbicki, Claudine Kieda, Michał Mączewski
    Academic press:
    Journal of American College of Cardiology - Heart Failure (rok: 2023, tom: in press, strony: in press), Wydawca: Elsevier
    Status:
    Accepted for publication
  5. Right ventricular myocardial oxygen tension is reduced in monocrotaline-induced pulmonary hypertension in the rat and restored by myo-inositol trispyrophosphate
    Authors:
    Marta Oknińska, Zuzanna Zambrowska, Karolina Zajda, Aleksandra Paterek, Klaudia Brodaczewska, Urszula Mackiewicz, Cezary Szczylik, Adam Torbicki, Claudine Kieda & Michał Mączewski
    Academic press:
    Scientific Reports (rok: 2021, tom: 11, strony: 18002), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1038/s41598-021-97470-6 - link to the publication
  6. Role of oxygen starvation in right ventricular decompensation/failure in pulmonary arterial hypertension
    Authors:
    Marta Oknińska, Karolina Zajda, Zuzanna Zambrowska, Małgorzata Grzanka, Aleksandra Paterek, Urszula Mackiewicz, Cezary Szczylik, Marcin Kurzyna, Agnieszka Piekiełko-Witkowska, Adam Torbicki, Claudine Kieda, Michał Mączewski
    Academic press:
    Journal of American College of Cardiology - Heart Failure (rok: 2023, tom: in press, strony: in press), Wydawca: Elsevier
    Status:
    Accepted for publication
  7. New potential treatment for cardiovascular disease through modulation of hemoglobin oxygen binding curve: Myo-inositol trispyrophosphate (ITPP), from cancer to cardiovascular disease
    Authors:
    Marta Oknińska, Urszula Mackiewicz, Karolina Zajda, Claudine Kieda, Michał Mączewski
    Academic press:
    Biomedicine & Pharmacotherapy (rok: 2022, tom: 154, strony: 113544), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.biopha.2022.113544 - link to the publication

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