Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Influence of oncogenic mutations on information transmission in the MAPK signaling pathway

2019/35/B/NZ2/03898

Keywords:

optogenetics live confocal imaging KRAS and PI3K mutations systems biology information theory

Descriptors:

  • NZ2_9: Systems biology
  • NZ2_10: Biological systems analysis, modelling and simulation

Panel:

NZ2 - Genetics, genomics: molecular genetics, genomics, proteomics, bioinformatics, systems biology, genetic epidemiology

Host institution :

Instytut Podstawowych Problemów Techniki Polskiej Akademii Nauk

woj.

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Tomasz Lipniacki 

Number of co-investigators in the project: 5

Call: OPUS 18 - announced on 2019-09-16

Amount awarded: 994 800 PLN

Project start date (Y-m-d): 2020-07-27

Project end date (Y-m-d): 2025-05-26

Project duration:: 58 months (the same as in the proposal)

Project status: Pending project

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (5)
  1. Predictive power of non-identifiable models
    Authors:
    Frederic Grabowski, Paweł Nałęcz-Jawecki, Tomasz Lipniacki
    Academic press:
    Scientific Reports (rok: 2023, tom: 13, strony: 11143), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1038/s41598-023-37939-8 - link to the publication
  2. The MAPK/ERK channel capacity exceeds 6 bit/hour
    Authors:
    Paweł Nałęcz-Jawecki, Paolo Armando Gagliardi, Marek Kochańczyk, Coralie Dessauges, Olivier Pertz,Tomasz Lipniacki
    Academic press:
    PLOS Computational Biology (rok: 2023, tom: 19, strony: e1011155), Wydawca: PLOS
    Status:
    Published
    DOI:
    10.1371/journal.pcbi.1011155 - link to the publication
  3. The rate of information transmission through the MAPK/ERK signaling pathway stimulated in a pulsatile manner
    Authors:
    Paweł Nałęcz-Jawecki, Paolo Armando Gagliardi,Marek Kochańczyk, Coralie Dessauges, Olivier Pertz, Tomasz Lipniacki
    Academic press:
    eLife (rok: 2022, ), Wydawca: eLife Sciences Publications Ltd.
    Status:
    Submitted
  4. Single-Cell Measurements and Modeling and Computation of Decision-Making Errors in a Molecular Signaling System with Two Output Molecules
    Authors:
    Ali Emadi, Tomasz Lipniacki, Andre Levchenko, and Ali Abdi.
    Academic press:
    Biology (rok: 2023, tom: 12, strony: 1461), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/biology12121461 - link to the publication
  5. The MAPK/ERK channel capacity exceeds 6 bit/hour
    Authors:
    Paweł Nałęcz-Jawecki, Paolo Armando Gagliardi, Marek Kochańczyk, Coralie Dessauges, Olivier Pertz,Tomasz Lipniacki
    Academic press:
    PLOS Computational Biology (rok: 2023, tom: 19, strony: e1011155), Wydawca: PLOS
    Status:
    Published
    DOI:
    10.1371/journal.pcbi.1011155 - link to the publication

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