Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Identification of unknown p53-terget genes with the help from actinomycin D and nutlin-3a - new facets of the major tumor suppressor

2019/35/O/NZ5/02600

Keywords:

p53 actinomycin D nutlin-3a innate immunity cancer

Descriptors:

  • NZ3_007:
  • NZ5_009:

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Centrum Onkologii - Instytut im. Marii Skłodowskiej-Curie, Oddział w Gliwicach

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Marek Rusin 

Number of co-investigators in the project: 2

Call: PRELUDIUM BIS 1 - announced on 2019-09-16

Amount awarded: 532 800 PLN

Project start date (Y-m-d): 2020-10-01

Project end date (Y-m-d): 2024-09-30

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

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Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (6)
  • Articles in post-conference publications (2)
  1. The p53 tumor suppressor modulates the expression of proteins that control natural killer cell activity.
    Authors:
    Będzińska A, Gdowicz-Kłosok A, Krześniak M, Łasut-Szyszka B, Zeman M, Chwieduk A, Smagur A, Jablonska J, Rusin M.
    Academic press:
    Cell Communication and Signaling (rok: 2026, tom: pending, strony: pending), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1186/s12964-026-02772-9 - link to the publication
  2. The Strong Activation of p53 Tumor Suppressor Drives the Synthesis of the Enigmatic Isoform of DUSP13 Protein.
    Authors:
    Krześniak M, Łasut-Szyszka B, Będzińska A, Gdowicz-Kłosok A, Rusin M.
    Academic press:
    Biomedicines. (rok: 2024, tom: 12, strony: 1449), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/biomedicines12071449 - link to the publication
  3. The Wheel of p53 Helps to Drive the Immune System.
    Authors:
    Barbara Łasut-Szyszka, Marek Rusin
    Academic press:
    Int J Mol Sci. (rok: 2023, tom: 24, strony: 7645), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms24087645 - link to the publication
  4. Transcriptomic and proteomic study of cancer cell lines exposed to actinomycin D and nutlin-3a reveals numerous, novel candidates for p53-regulated genes.
    Authors:
    Łasut-Szyszka B, Gdowicz-Kłosok A, Małachowska B, Krześniak M, Będzińska A, Gawin M, Pietrowska M, Rusin M.
    Academic press:
    Chem Biol Interact. (rok: 2024, tom: 392, strony: 110946), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.cbi.2024.110946 - link to the publication
  5. Strong activation of p53 by actinomycin D and nutlin-3a overcomes the resistance of cancer cells to the pro-apoptotic activity of the FAS ligand.
    Authors:
    Łasut-Szyszka B, Gdowicz-Kłosok A, Krześniak M, Głowala-Kosińska M, Będzińska A, Rusin M.
    Academic press:
    Apoptosis (rok: 2024, tom: 29, strony: 1515-1528), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s10495-024-02000-0 - link to the publication
  6. The puzzling regulation of the interferon signaling system by the p53 tumor suppressor protein.
    Authors:
    Będzińska A, Łasut-Szyszka B, Krześniak M, Gdowicz-Kłosok A, Rusin M.
    Academic press:
    Cell Mol Life Sci. (rok: 2025, tom: 82, strony: 233), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00018-025-05763-0 - link to the publication
  1. Sensitizing cancer cells to the FAS ligand through strong activation of the p53 protein may prove to be a spectacular solution in anticancer therapy
    Authors:
    Lasut-Szyszka, B, Gdowicz-Klosok, A, Krzesniak, M, Bedzinska, A, Glowala-Kosinska, M, Rusin, M
    Conference:
    FEBS OPEN BIO (rok: 2024, tom: 48th FEBS Congress, strony: 425-426), Wydawca: Wiley
    Data:
    konferencja 29.06.2024-03.07.2024
    Status:
    Published
    DOI:
    10.1002/2211-5463.13837 - link to the publication
  2. The regulation of interferon signaling system by p53 tumor suppressor protein
    Authors:
    Agnieszka Będzińska, Barbara Łasut-Szyszka, Marek Rusin
    Conference:
    FEBS OPEN BIO (rok: 2022, tom: The Biochemistry Global Summit, 25th IUBMB Congress, 46th FEBS Congress, 15th PABMB Congress, July 9–14, 2022, Lisbon, Portugal, strony: 213), Wydawca: Wiley
    Data:
    konferencja 9-14 07 2022
    Status:
    Published
    DOI:
    10.1002/2211-5463.13440 - link to the publication

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