Projects funded by the NCN

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Information of the project and the call

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The use of Galleria mellonella larvae as an alternative to mammalian research models - a determination of selected cytokine-like proteins in hemocytes after infection with the fungus Conidiobolus coronatus and after exposure to its metabolites

2019/35/D/NZ6/01685

Keywords:

Galleria mellonella Conidiobolus coronatus cytokines hemocytes fungal infection alkaloids research model

Descriptors:

  • NZ6_1: Adaptive and innate immunity
  • NZ6_7: Mycology
  • NZ4_2: Physiology

Panel:

NZ6 - Human and animal immunology and infection: immunity, immune disorders, immunotherapy, infectious and invasive diseases, microbiology, transplantology, allergology

Host institution :

Muzeum i Instytut Zoologii Polskiej Akademii Nauk

woj.

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Anna Katarzyna Wrońska 

Number of co-investigators in the project: 3

Call: SONATA 15 - announced on 2019-09-16

Amount awarded: 1 876 716 PLN

Project start date (Y-m-d): 2020-07-22

Project end date (Y-m-d): 2025-07-21

Project duration:: 60 months (the same as in the proposal)

Project status: Pending project

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (22)
  1. Intracellular cytokine detection based on flow cytometry in hemocytes from Galleria mellonella larvae: A new protocol
    Authors:
    Wrońska A.K., Kaczmarek A., Sobich J., Grzelak S., Boguś M. I.
    Academic press:
    Plos One (rok: 2022, tom: 17 (9), strony: 45666), Wydawca: Public Library of Science
    Status:
    Published
    DOI:
    10.1371/journal.pone.0274120 - link to the publication
  2. The multifunctional role of IFN-γ in Galleria mellonella (Lepidoptera) immunocompetent cells
    Authors:
    Agata Kaczmarek, Anna Katarzyna Wrońska, Justyna Sobich, Mieczysława Irena Boguś
    Academic press:
    Cytokine (rok: 2025, tom: 185, strony: 45670), Wydawca: Elsevier Ltd.
    Status:
    Published
    DOI:
    10.1016/j.cyto.2024.156804 - link to the publication
  3. The effect of infection with the entomopathogenic fungus Conidiobolus coronatus (Entomopthorales) on eighteen cytokine-like proteins in Galleria mellonella (Lepidoptera) larvae
    Authors:
    Anna Katarzyna Wrońska, Agata Kaczmarek, Justyna Sobich, Mieczysława Irena Boguś
    Academic press:
    Frontiers in Immunology (rok: 2024, tom: 15, strony: 45671), Wydawca: Frontiers Media SA
    Status:
    Published
    DOI:
    10.3389/fimmu.2024.1385863 - link to the publication
  4. Insect cuticular compounds affect Conidiobolus coronatus (Entomopthorales) sporulation and the activity of enzymes involved in fungal infection
    Authors:
    Włóka, E., Boguś, M.I., Wrońska, A.K., Drozdowski M., Kaczmarek A., Sobich J., Gołębiowski M.
    Academic press:
    Scientific Reports (rok: 2022, tom: 12, strony: 45676), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1038/s41598-022-17960-z - link to the publication
  5. Insect cuticular compounds affect Conidiobolus coronatus (Entomopthorales) sporulation and the activity of enzymes involved in fungal infection
    Authors:
    Włóka, E., Boguś, M.I., Wrońska, A.K., Drozdowski M., Kaczmarek A., Sobich J., Gołębiowski M.
    Academic press:
    Scientific Reports (rok: 2022, tom: 12, strony: 45676), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1038/s41598-022-17960-z - link to the publication
  6. Insect cuticular compounds affect Conidiobolus coronatus (Entomopthorales) sporulation and the activity of enzymes involved in fungal infection
    Authors:
    Włóka, E., Boguś, M.I., Wrońska, A.K., Drozdowski M., Kaczmarek A., Sobich J., Gołębiowski M.
    Academic press:
    Scientific Reports (rok: 2022, tom: 12, strony: 45676), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1038/s41598-022-17960-z - link to the publication
  7. Intracellular cytokine detection based on flow cytometry in hemocytes from Galleria mellonella larvae : a new protocol
    Authors:
    Anna Katarzyna Wrońska, Agata Kaczmarek, Mieczysława Irena Boguś
    Academic press:
    PLOS One
    Status:
    Submitted
  8. The Changes in Mitochondrial Morphology and Physiology Accompanying Apoptosis in Galleria mellonella (Lepidoptera) Immunocompetent Cells during Conidiobolus coronatus (Entomophthorales) Infection
    Authors:
    Agata Kaczmarek, Anna Katarzyna Wrońska, Mieczysława Irena Boguś
    Academic press:
    International Journal of Molecular Sciences (rok: 2023, tom: 24 (12), strony: 10169), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms241210169 - link to the publication
  9. Infection of Galleria mellonella (Lepidoptera) Larvae With the Entomopathogenic Fungus Conidiobolus coronatus (Entomophthorales) Induces Apoptosis of Hemocytes and Affects the Concentration of Eicosanoids in the Hemolymph
    Authors:
    Anna Katarzyna Wrońska, Agata Kaczmarek, Michalina Kazek, Mieczysława Irena Boguś
    Academic press:
    Frontiers in Physiology (rok: 2022, tom: 12, strony: 45672), Wydawca: Frontiers Media SA
    Status:
    Published
    DOI:
    10.3389/fphys.2021.774086 - link to the publication
  10. Intracellular cytokine detection based on flow cytometry in hemocytes from Galleria mellonella larvae: A new protocol
    Authors:
    Wrońska A.K., Kaczmarek A., Sobich J., Grzelak S., Boguś M. I.
    Academic press:
    Plos One (rok: 2022, tom: 17 (9), strony: 45666), Wydawca: Public Library of Science
    Status:
    Published
    DOI:
    10.1371/journal.pone.0274120 - link to the publication
  11. Intracellular cytokine detection based on flow cytometry in hemocytes from Galleria mellonella larvae : a new protocol
    Authors:
    Anna Katarzyna Wrońska, Agata Kaczmarek, Mieczysława Irena Boguś
    Academic press:
    PLOS One
    Status:
    Submitted
  12. Changes in histamine, HSF1, Cysteinyl leukotriene, TLR1 and TLR2 in Galleria mellonella hemolymph after Conidiobolus coronatus infection
    Authors:
    Justyna Sobich, Anna Katarzyna Wrońska, Agata Kaczmarek, Mieczysława Irena Boguś
    Academic press:
    The European Zoological Journal (rok: 2023, tom: 90 (2), strony: 762-774), Wydawca: Taylor & Francis Group
    Status:
    Published
    DOI:
    10.1080/24750263.2023.2276353 - link to the publication
  13. Lipids as a key element of insect defense systems
    Authors:
    Anna Katarzyna Wrońska, Agata Kaczmarek, Mieczysława Irena Boguś, Anna Kuna
    Academic press:
    Frontiers in Genetics (rok: 2023, tom: 14, strony: 45674), Wydawca: Frontiers Media
    Status:
    Published
    DOI:
    10.3389/fgene.2023.1183659 - link to the publication
  14. Intracellular cytokine detection based on flow cytometry in hemocytes from Galleria mellonella larvae : a new protocol
    Authors:
    Anna Katarzyna Wrońska, Agata Kaczmarek, Mieczysława Irena Boguś
    Academic press:
    PLOS One
    Status:
    Submitted
  15. The Changes in Mitochondrial Morphology and Physiology Accompanying Apoptosis in Galleria mellonella (Lepidoptera) Immunocompetent Cells during Conidiobolus coronatus (Entomophthorales) Infection
    Authors:
    Agata Kaczmarek, Anna Katarzyna Wrońska, Mieczysława Irena Boguś
    Academic press:
    International Journal of Molecular Sciences (rok: 2023, tom: 24 (12), strony: 10169), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms241210169 - link to the publication
  16. Infection of Galleria mellonella (Lepidoptera) Larvae With the Entomopathogenic Fungus Conidiobolus coronatus (Entomophthorales) Induces Apoptosis of Hemocytes and Affects the Concentration of Eicosanoids in the Hemolymph
    Authors:
    Anna Katarzyna Wrońska, Agata Kaczmarek, Michalina Kazek, Mieczysława Irena Boguś
    Academic press:
    Frontiers in Physiology (rok: 2022, tom: 12, strony: 45672), Wydawca: Frontiers Media SA
    Status:
    Published
    DOI:
    10.3389/fphys.2021.774086 - link to the publication
  17. Intracellular cytokine detection based on flow cytometry in hemocytes from Galleria mellonella larvae: A new protocol
    Authors:
    Wrońska A.K., Kaczmarek A., Sobich J., Grzelak S., Boguś M. I.
    Academic press:
    Plos One (rok: 2022, tom: 17 (9), strony: 45666), Wydawca: Public Library of Science
    Status:
    Published
    DOI:
    10.1371/journal.pone.0274120 - link to the publication
  18. Lipids as a key element of insect defense systems
    Authors:
    Anna Katarzyna Wrońska, Agata Kaczmarek, Mieczysława Irena Boguś, Anna Kuna
    Academic press:
    Frontiers in Genetics (rok: 2023, tom: 14, strony: 45674), Wydawca: Frontiers Media
    Status:
    Published
    DOI:
    10.3389/fgene.2023.1183659 - link to the publication
  19. Changes in histamine, HSF1, Cysteinyl leukotriene, TLR1 and TLR2 in Galleria mellonella hemolymph after Conidiobolus coronatus infection
    Authors:
    Justyna Sobich, Anna Katarzyna Wrońska, Agata Kaczmarek, Mieczysława Irena Boguś
    Academic press:
    The European Zoological Journal (rok: 2023, tom: 90 (2), strony: 762-774), Wydawca: Taylor & Francis Group
    Status:
    Published
    DOI:
    10.1080/24750263.2023.2276353 - link to the publication
  20. Intracellular cytokine detection based on flow cytometry in hemocytes from Galleria mellonella larvae : a new protocol
    Authors:
    Anna Katarzyna Wrońska, Agata Kaczmarek, Mieczysława Irena Boguś
    Academic press:
    PLOS One
    Status:
    Submitted
  21. Infection of Galleria mellonella (Lepidoptera) Larvae With the Entomopathogenic Fungus Conidiobolus coronatus (Entomophthorales) Induces Apoptosis of Hemocytes and Affects the Concentration of Eicosanoids in the Hemolymph
    Authors:
    Anna Katarzyna Wrońska, Agata Kaczmarek, Michalina Kazek, Mieczysława Irena Boguś
    Academic press:
    Frontiers in Physiology (rok: 2022, tom: 12, strony: 45672), Wydawca: Frontiers Media SA
    Status:
    Published
    DOI:
    10.3389/fphys.2021.774086 - link to the publication
  22. Infection of Galleria mellonella (Lepidoptera) Larvae With the Entomopathogenic Fungus Conidiobolus coronatus (Entomophthorales) Induces Apoptosis of Hemocytes and Affects the Concentration of Eicosanoids in the Hemolymph
    Authors:
    Anna Katarzyna Wrońska, Agata Kaczmarek, Michalina Kazek, Mieczysława Irena Boguś
    Academic press:
    Frontiers in Physiology (rok: 2022, )
    Status:
    Published
    DOI:
    10.3389/fphys.2021.774086 - link to the publication

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