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Impact of indole-3-propionic acid, a gut microbiota-derived metabolite of tryptophan, on cardiovascular system in rats.

2019/35/N/NZ4/01111

Keywords:

microbiota indole-3-propionic acid blood pressure hypertension,

Descriptors:

  • NZ4_2: Physiology

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Warszawski Uniwersytet Medyczny

woj.

Other projects carried out by the institution 

Principal investigator (from the host institution):

Piotr Michał Konopelski 

Number of co-investigators in the project: 2

Call: PRELUDIUM 18 - announced on 2019-09-16

Amount awarded: 139 992 PLN

Project start date (Y-m-d): 2020-06-25

Project end date (Y-m-d): 2022-12-24

Project duration:: 30 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (4)
  • Articles in post-conference publications (1)
  1. Biological Effects of Indole-3-Propionic Acid, a Gut Microbiota-Derived Metabolite, and Its Precursor Tryptophan in Mammals' Health and Disease
    Authors:
    Piotr Konopelski, Izabella Mogilnicka
    Academic press:
    International Journal of Molecular Sciences (rok: 2022, tom: 23, strony: 45676), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms23031222 - link to the publication
  2. Indole-3-propionic acid, a tryptophan-derived bacterial metabolite, increases blood pressure via cardiac and vascular mechanisms in rats
    Authors:
    Piotr Konopelski, Dawid Chabowski, Marta Aleksandrowicz, Ewa Kozniewska, Piotr Podsadni, Agnieszka Szczepanska, Marcin Ufnal
    Academic press:
    American Journal of Physiology-Regulatory Integrative and Comparative Physiology (rok: 2021, tom: 321, strony: R969-R981), Wydawca: The American Physiological Society
    Status:
    Published
    DOI:
    10.1152/ajpregu.00142.2021 - link to the publication
  3. Biological Effects of Indole-3-Propionic Acid, a Gut Microbiota-Derived Metabolite, and Its Precursor Tryptophan in Mammals' Health and Disease
    Authors:
    Piotr Konopelski, Izabella Mogilnicka
    Academic press:
    International Journal of Molecular Sciences (rok: 2022, tom: 23, strony: 45676), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms23031222 - link to the publication
  4. Indole-3-propionic acid, a tryptophan-derived bacterial metabolite, increases blood pressure via cardiac and vascular mechanisms in rats
    Authors:
    Piotr Konopelski, Dawid Chabowski, Marta Aleksandrowicz, Ewa Kozniewska, Piotr Podsadni, Agnieszka Szczepanska, Marcin Ufnal
    Academic press:
    American Journal of Physiology-Regulatory Integrative and Comparative Physiology (rok: 2021, tom: 321, strony: R969-R981), Wydawca: The American Physiological Society
    Status:
    Published
    DOI:
    10.1152/ajpregu.00142.2021 - link to the publication
  1. Indole-3-propionic Acid, Bacterial Metabolite of Tryptophan, Increases Blood Pressure in Normotensive and Hypertensive Rats
    Authors:
    Piotr Konopelski, Dawid Chabowski, Marta Aleksandrowicz, Ewa Kozniewska, Piotr Podsadni, Agnieszka Szczepanska, Marcin Ufnal
    Conference:
    The FASEB Journal Volume 36, Issue S1 (rok: 2022, tom: Experimental Biology 2022, strony: 1), Wydawca: FASEB
    Data:
    konferencja 2-5 kwietnia 2022
    Status:
    Published
    DOI:
    10.1096/fasebj.2022.36.S1.R3359 - link to the publication

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