Projects funded by the NCN
Hijacking the ubiquitin-proteasome system by the UL49.5 protein of bovine herpesvirus 1 as an immune evasion strategy – elucidating the mechanism of TAP transporter degradation
2019/35/N/NZ6/00829
Keywords:
TAP ERAD MHC I antigens presentation
Descriptors:
- NZ6_5: Virology
- NZ1_10: Microbiology
- NZ3_1: Cell biology
Panel:
NZ6 - Human and animal immunology and infection: immunity, immune disorders, immunotherapy, infectious and invasive diseases, microbiology, transplantology, allergology
Host institution :
Uniwersytet Gdański, Międzyuczelniany Wydział Biotechnologii Uniwersytetu Gdańskiego i Gdańskiego Uniwersytetu Medycznego
woj.
Principal investigator (from the host institution):
Number of co-investigators in the project: 2
Call: PRELUDIUM 18 - announced on 2019-09-16
Amount awarded: 139 200 PLN
Project start date (Y-m-d): 2020-06-19
Project end date (Y-m-d): 2023-06-18
Project duration:: 36 months (the same as in the proposal)
Project status: Project settled
Project description
Download the project description in a pdf file
Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Information in the final report
- Publication in academic press/journals (1)
- The herpesvirus UL49.5 protein hijacks a cellular C-degron pathway to drive TAP transporter degradationAuthors:Magda Wąchalska, Celeste Riepe, Magdalena J. Ślusarz, Małgorzata Graul, Lukasz S. Borowski, Wenjie Qiao , Michalina Foltyńska, Jan E. Carette, Krystyna Bieńkowska-Szewczyk, Roman J. Szczesny, Ron R. Kopito, Andrea D. LipińskaAcademic press:Proceedings of the National Academy of Sciences (PNAS) (rok: 2024, tom: 121, strony: -), Wydawca: -Status:PublishedDOI:10.1073/pnas.2309841121 - link to the publication