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Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Influence of chemical modifications of urolithin A molecule on its metabolism and biological activities in vitro.

2019/35/O/NZ7/00619

Keywords:

gut microbiota urolithins metabolism anti-inflammatory activity

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Warszawski Uniwersytet Medyczny, Wydział Farmaceutyczny

woj.

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Jakub Patryk Piwowarski 

Number of co-investigators in the project: 2

Call: PRELUDIUM BIS 1 - announced on 2019-09-16

Amount awarded: 532 800 PLN

Project start date (Y-m-d): 2020-10-01

Project end date (Y-m-d): 2024-09-30

Project duration:: 48 months (the same as in the proposal)

Project status: Project completed

Project description

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Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (5)
  1. Urolithin A conjugation with NSAIDs inhibits its glucuronidation and maintains improvement of Caco-2 monolayers' barrier function
    Authors:
    Korczak M, Roszkowski P, Skowrońska W, Żołdak KM, Popowski D, Granica S, Piwowarski JP.
    Academic press:
    Biomedicine & Pharmacotherapy (rok: 2023, tom: 169, strony: 115932), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.biopha.2023.115932 - link to the publication
  2. Conjugates of urolithin A with NSAIDs, their stability, cytotoxicity, and anti-inflammatory potential
    Authors:
    Maciej Korczak, Piotr Roszkowski, Sebastian Granica & Jakub P. Piwowarski
    Academic press:
    Scientific Reports (rok: 2022, tom: 12, strony: 11676), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1038/s41598-022-15870-8 - link to the publication
  3. Phytotherapy of mood disorders in the light of microbiota-gut-brain axis.
    Authors:
    Maciej Korczak, Maciej Pilecki, Sebastian Granica, Aleksandra Gorczynska, Karolina A. Pawłowska, Jakub P. Piwowarski
    Academic press:
    Phytomedicine (rok: 2023, tom: 111, strony: 154642), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.phymed.2023.154642 - link to the publication
  4. Phytotherapy of mood disorders in the light of microbiota-gut-brain axis.
    Authors:
    Maciej Korczak, Maciej Pilecki, Sebastian Granica, Aleksandra Gorczynska, Karolina A. Pawłowska, Jakub P. Piwowarski
    Academic press:
    Phytomedicine (rok: 2023, tom: 111, strony: 154642), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.phymed.2023.154642 - link to the publication
  5. Conjugates of urolithin A with NSAIDs, their stability, cytotoxicity, and anti-inflammatory potential
    Authors:
    Maciej Korczak, Piotr Roszkowski, Sebastian Granica & Jakub P. Piwowarski
    Academic press:
    Scientific Reports (rok: 2022, tom: 12, strony: 11676), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1038/s41598-022-15870-8 - link to the publication

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