Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Molecular and structural insights into human pseudouridine synthase 3

2019/35/D/NZ1/02397

Keywords:

protein structure cryo-EM pseudouridine pseudouridine synthase

Descriptors:

  • NZ1_4: Structural biology
  • NZ1_2: Biochemistry

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Uniwersytet Jagielloński, Małopolskie Centrum Biotechnologii Uniwersytetu Jagiellońskiego

woj.

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Ting-Yu Lin 

Number of co-investigators in the project: 3

Call: SONATA 15 - announced on 2019-09-16

Amount awarded: 957 966 PLN

Project start date (Y-m-d): 2020-11-13

Project end date (Y-m-d): 2023-01-12

Project duration:: 26 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (3)
  • Book publications / chapters in book publications (2)
  1. Pseudouridines in RNAs: switching atoms means shifting paradigms
    Authors:
    Ting-Yu Lin,Rahul Mehta,Sebastian Glatt
    Academic press:
    FEBS letters (rok: 2021, tom: 18, strony: 2310-2322), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/1873-3468.14188 - link to the publication
  2. Destabilization of mutated human PUS3 protein causes intellectual disability
    Authors:
    Ting-Yu Lin, Robert Smigiel, Bozena Kuzniewska, Joanna J. Chmielewska, Joanna Kosińska, Mateusz Biela, Anna Biela, Anna Kościelniak, Dominika Dobosz, Izabela Laczmanska, Andrzej Chramiec-Głąbik, Jakub Jeżowski, Jakub Nowak, Monika Gos, Sylwia Rzonca-Niewczas, Magdalena Dziembowska, Rafał Ploski, Sebastian Glatt
    Academic press:
    Human mutation (rok: 2022, tom: 43, strony: 2063-2078), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/humu.24471 - link to the publication
  3. Pseudouridines in RNAs: switching atoms means shifting paradigms
    Authors:
    Ting-Yu Lin,Rahul Mehta,Sebastian Glatt
    Academic press:
    FEBS letters (rok: 2021, tom: 18, strony: 2310-2322), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/1873-3468.14188 - link to the publication
  1. Electrophoretic mobility shift assay (EMSA) and microscale thermophoresis (MST) methods to measure interactions between tRNAs and their modifying enzymes
    Authors:
    Andrzej Chramiec-Głąbik, Michał Rawski, Sebastian Glatt & Ting-Yu Lin
    Book:
    RNA-Protein Complex and Interaction (rok: 2021, ), Wydawca: Springer
    Status:
    Accepted for publication
  2. Electrophoretic mobility shift assay (EMSA) and microscale thermophoresis (MST) methods to measure interactions between tRNAs and their modifying enzymes
    Authors:
    Andrzej Chramiec-Głąbik, Michał Rawski, Sebastian Glatt & Ting-Yu Lin
    Book:
    RNA-Protein Complex and Interaction (rok: 2021, ), Wydawca: Springer
    Status:
    Accepted for publication

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