Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Hsp70 and its cochaperones in protein recovery from aggregates

2019/35/B/NZ1/01475

Keywords:

protein aggregation protein folding J-domain proteins nucleotide exchange factors protein disaggregation protein conformational diseases

Descriptors:

  • NZ1_2: Biochemistry
  • NZ1_1: Molecular biology

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Uniwersytet Gdański, Międzyuczelniany Wydział Biotechnologii Uniwersytetu Gdańskiego i Gdańskiego Uniwersytetu Medycznego

woj.

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Krzysztof Piotr Liberek 

Number of co-investigators in the project: 5

Call: OPUS 18 - announced on 2019-09-16

Amount awarded: 2 450 400 PLN

Project start date (Y-m-d): 2020-06-18

Project end date (Y-m-d): 2025-06-17

Project duration:: 60 months (the same as in the proposal)

Project status: Pending project

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (8)
  1. Class-specific interactions between Sis1 J-domain protein and Hsp70 chaperone potentiate disaggregation of misfolded proteins
    Authors:
    Hubert Wyszkowski , Anna Janta , Wiktoria Sztangierska , Igor Obuchowski , Tomasz Chamera, Agnieszka Kłosowska, and Krzysztof Liberek,
    Academic press:
    Proceedings of the National Academy of Sciences of the United States of America (rok: 2021, tom: Vol. 118 No. 49 e2108163118, strony: nd.), Wydawca: PNAS
    Status:
    Published
    DOI:
    10.1073/pnas.2108163118 - link to the publication
  2. Differential contributions of the proteasome, autophagy, and chaperones to the clearance of arsenite-induced protein aggregates in yeast
    Authors:
    Sansan Hua, Agnieszka Kłosowska , Joana I. Rodrigues , Gabriel Petelski, Lidia A. Esquembre, Emma Lorentzon , Lars F. Olsen, Krzysztof Liberek, and Markus J. Tamás
    Academic press:
    Journal of Biological Chemistry (rok: 2022, tom: 298, strony: 102680), Wydawca: American Society for Biochemistry and Molecular Biology
    Status:
    Published
    DOI:
    10.1016/j.jbc.2022.102680 - link to the publication
  3. Differential contributions of the proteasome, autophagy, and chaperones to the clearance of arsenite-induced protein aggregates in yeast
    Authors:
    Sansan Hua, Agnieszka Kłosowska , Joana I. Rodrigues , Gabriel Petelski, Lidia A. Esquembre, Emma Lorentzon , Lars F. Olsen, Krzysztof Liberek, and Markus J. Tamás
    Academic press:
    Journal of Biological Chemistry (rok: 2022, tom: 298, strony: 102680), Wydawca: American Society for Biochemistry and Molecular Biology
    Status:
    Published
    DOI:
    10.1016/j.jbc.2022.102680 - link to the publication
  4. Differential contributions of the proteasome, autophagy, and chaperones to the clearance of arsenite-induced protein aggregates in yeast
    Authors:
    Sansan Hua, Agnieszka Kłosowska , Joana I. Rodrigues , Gabriel Petelski, Lidia A. Esquembre, Emma Lorentzon , Lars F. Olsen, Krzysztof Liberek, and Markus J. Tamás
    Academic press:
    Journal of Biological Chemistry (rok: 2022, tom: 298, strony: 102680), Wydawca: American Society for Biochemistry and Molecular Biology
    Status:
    Published
    DOI:
    10.1016/j.jbc.2022.102680 - link to the publication
  5. Class-specific interactions between Sis1 J-domain protein and Hsp70 chaperone potentiate disaggregation of misfolded proteins
    Authors:
    Hubert Wyszkowski , Anna Janta , Wiktoria Sztangierska , Igor Obuchowski , Tomasz Chamera, Agnieszka Kłosowska, and Krzysztof Liberek,
    Academic press:
    Proceedings of the National Academy of Sciences of the United States of America (rok: 2021, tom: Vol. 118 No. 49 e2108163118, strony: nd.), Wydawca: PNAS
    Status:
    Published
    DOI:
    10.1073/pnas.2108163118 - link to the publication
  6. Early steps of protein disaggregation by Hsp70 chaperone and class B J-domain proteins are shaped by Hsp110
    Authors:
    Wiktoria Sztangierska, Hubert Wyszkowski, Maria Pokornowska, Klaudia Kochanowicz, Michal Rychłowski, Krzysztof Liberek*, Agnieszka Kłosowska*
    Academic press:
    eLife (rok: 2024, tom: 13:RP94795, strony: 45678), Wydawca: eLife Sciences Publications, Ltd
    Status:
    Published
    DOI:
    10.7554/eLife.94795 - link to the publication
  7. Class-specific interactions between Sis1 J-domain protein and Hsp70 chaperone potentiate disaggregation of misfolded proteins
    Authors:
    Hubert Wyszkowski , Anna Janta , Wiktoria Sztangierska , Igor Obuchowski , Tomasz Chamera, Agnieszka Kłosowska, and Krzysztof Liberek,
    Academic press:
    Proceedings of the National Academy of Sciences of the United States of America (rok: 2021, tom: Vol. 118 No. 49 e2108163118, strony: nd.), Wydawca: PNAS
    Status:
    Published
    DOI:
    10.1073/pnas.2108163118 - link to the publication
  8. Class-specific interactions between Sis1 J-domain protein and Hsp70 chaperone potentiate disaggregation of misfolded proteins
    Authors:
    Hubert Wyszkowski , Anna Janta , Wiktoria Sztangierska , Igor Obuchowski , Tomasz Chamera, Agnieszka Kłosowska, and Krzysztof Liberek,
    Academic press:
    Proceedings of the National Academy of Sciences of the United States of America (rok: 2021, tom: Vol. 118 No. 49 e2108163118, strony: nd.), Wydawca: PNAS
    Status:
    Published
    DOI:
    10.1073/pnas.2108163118 - link to the publication

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