Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Molecular basis of transcriptional interference by cross-talk between transcriptional factors and its effect on bacterial fitness

2019/35/B/NZ2/00701

Keywords:

bacterial transcription transcription factors gene expression regulation Escherichia coli gene regulatory networks,

Descriptors:

  • NZ2_1: Molecular genetics
  • NZ2_2: Genomics, transcriptomics, epigenomics
  • NZ1_1: Molecular biology

Panel:

NZ2 - Genetics, genomics: molecular genetics, genomics, proteomics, bioinformatics, systems biology, genetic epidemiology

Host institution :

Uniwersytet Gdański, Wydział Biologii

woj.

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Iwona - Mruk 

Number of co-investigators in the project: 3

Call: OPUS 18 - announced on 2019-09-16

Amount awarded: 1 359 600 PLN

Project start date (Y-m-d): 2020-07-22

Project end date (Y-m-d): 2025-07-21

Project duration:: 60 months (the same as in the proposal)

Project status: Pending project

Project description

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Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (3)
  1. MOLECULAR BASIS FOR LETHAL CROSS-TALK BETWEEN TWO UNRELATED BACTERIAL TRANSCRIPTION FACTORS – THE REGULATORY PROTEIN OF A RESTRICTION-MODIFICATION SYSTEM AND THE REPRESSOR OF A DEFECTIVE PROPHAGE.
    Authors:
    WISNIEWSKA A, WONS E, POTRYKUS K, HINRICHS R., GUCWA K, GRAUMANN P, MRUK I
    Academic press:
    Nucleic Acids Research (rok: 2022, tom: 50(19), strony: 10964-10980), Wydawca: Oxford University Press
    Status:
    Published
    DOI:
    10.1093/nar/gkac914 - link to the publication
  2. MOLECULAR BASIS FOR LETHAL CROSS-TALK BETWEEN TWO UNRELATED BACTERIAL TRANSCRIPTION FACTORS – THE REGULATORY PROTEIN OF A RESTRICTION-MODIFICATION SYSTEM AND THE REPRESSOR OF A DEFECTIVE PROPHAGE.
    Authors:
    WISNIEWSKA A, WONS E, POTRYKUS K, HINRICHS R., GUCWA K, GRAUMANN P, MRUK I
    Academic press:
    Nucleic Acids Research (rok: 2022, tom: 50(19), strony: 10964-10980), Wydawca: Oxford University Press
    Status:
    Published
    DOI:
    10.1093/nar/gkac914 - link to the publication
  3. LETHAL PERTURBATION OF AN ESCHERICHIA COLI REGULATORY NETWORK IS TRIGGERED BY A RESTRICTION-MODIFICATION SYSTEM'S REGULATOR AND CAN BE MITIGATED BY EXCISION OF THE CRYPTIC PROPHAGE RAC
    Authors:
    GUCWA K, WONS E, WISNIEWSKA A, JAKALSKI M, DUBIAK Z, KOZŁOWSKI LP, MRUK I
    Academic press:
    Nucleic Acids Research (rok: 2023, tom: Online ahead of print, strony: Online ahead of print), Wydawca: Oxford University Press
    Status:
    Published
    DOI:
    10.1093/nar/gkad1234 - link to the publication

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