Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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The impact of cytoplasmic polyadenylation on local translation in neurons

2019/34/H/NZ3/00733

Keywords:

neurons polyadenylation local translation LTP TENT5 TENT2(GLD2) direct RNA sequencing

Descriptors:

  • NZ3_5: Molecular neurobiology
  • NZ2_2: Genomics, transcriptomics, epigenomics

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Międzynarodowy Instytut Biologii Molekularnej i Komórkowej w Warszawie

woj.

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Andrzej Stanisław Dziembowski 

Number of co-investigators in the project: 10

Call: GRIEG 1 - announced on 2019-06-17

Amount awarded: 7 018 052 PLN

Project start date (Y-m-d): 2020-09-01

Project end date (Y-m-d): 2024-04-30

Project duration:: 44 months (the same as in the proposal)

Project status: Project settled

Project description

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Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (4)
  1. The polyadenylation landscape after in vivo long-term potentiation in the rat brain
    Authors:
    Natalia Gumińska, Francois P Pauzin, Bożena Kuźniewska, Jacek Miłek, Patrycja Wardaszka, Paweł S. Krawczyk, Seweryn Mroczek, Sebastian Jeleń, Patrick U. Pagenhart, Clive R. Bramham, Andrzej Dziembowski, Magdalena Dziembowska
    Academic press:
    Genome Research (rok: 2024, tom: x, strony: 45686), Wydawca: CSHLP
    Status:
    Submitted
  2. Terminal nucleotidyltransferase Tent2 microRNA tailing regulates excitatory/inhibitory balance in the hippocampus
    Authors:
    Patrycja Wardaszka , Bożena Kuźniewska , Natalia Guminska , Anna Hojka-Osinska , Monika Puchalska , Jacek Milek , Aleksandra Stawikowska , Dr. Paweł Krawczyk , Dr. Francois Pauzin , Tomasz Wojtowicz , Prof. Kasia Radwańska , Clive Bramham , Prof. Andrzej Dziembowski, Magdalena Dziembowska
    Academic press:
    EMBO Reports (rok: 2025, tom: x, strony: x), Wydawca: EMBO
    Status:
    Submitted
  3. TENT5-mediated polyadenylation of mRNAs encoding secreted proteins is essential for gametogenesis in mice
    Authors:
    Michał Brouze, Agnieszka Czarnocka-Cieciura, Olga Gewartowska1,3,4, Monika Kusio-Kobiałka1 , Kamil Jachacy, Marcin Szpila, Bartosz Tarkowski, Jakub Gruchota, Paweł Krawczyk, Seweryn Mroczek, Ewa Borsuk & Andrzej Dziembowski
    Academic press:
    Nature Communications (rok: 2024, tom: XX, strony: 45677), Wydawca: Nature
    Status:
    Published
    DOI:
    10.1038/s41467-024-49479-4 - link to the publication
  4. Comprehensive analysis of Poly (A) tails in Mouse Testis and Ovaries using Nanopore direct RNA Sequencing
    Authors:
    Agnieszka Czarnocka-Cieciura , Mr Michał Brouze , Dr Seweryn Mroczek , Dr Olga Gewartowka , Dr Pawel Krawczyk , Dr Natalia Gumińska
    Academic press:
    Scinetific Data (rok: 2024, )
    Status:
    Submitted

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