Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Intracelluar trafficking in murine and human pancreatic development and physiology

2019/33/B/NZ3/01226

Keywords:

pancreas intracellular trafficking insulin secretion hpsc-pancreatic differentiation diabetes gene editing

Descriptors:

  • NZ3_8: Stem cell biology
  • NZ3_2: Cell physiology
  • NZ3_12: Developmental genetics in animals

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Biologii

woj.

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Małgorzata Borowiak 

Number of co-investigators in the project: 6

Call: OPUS 17 - announced on 2019-03-15

Amount awarded: 2 076 890 PLN

Project start date (Y-m-d): 2020-03-16

Project end date (Y-m-d): 2024-09-15

Project duration:: 54 months (the same as in the proposal)

Project status: Project completed

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (11)
  1. Diabetes and SARS-CoV-2-Is There a Mutual Connection?
    Authors:
    Jedrzejak AP, Urbaniak EK, Wasko JA, Ziojla N, Borowiak M
    Academic press:
    Frontiers in Cell and Developmental Biology (rok: 2022, tom: 10, strony: 913305), Wydawca: Frontiers Media S.A.
    Status:
    Published
    DOI:
    10.3389/fcell.2022.913305 - link to the publication
  2. Diabetes and SARS-CoV-2-Is There a Mutual Connection?
    Authors:
    Jedrzejak AP, Urbaniak EK, Wasko JA, Ziojla N, Borowiak M
    Academic press:
    Frontiers in Cell and Developmental Biology (rok: 2022, tom: 10, strony: 913305), Wydawca: Frontiers Media S.A.
    Status:
    Published
    DOI:
    10.3389/fcell.2022.913305 - link to the publication
  3. Human pancreatic microenvironment promotes β-cell differentiation via non-canonical WNT5A/JNK and BMP signaling
    Authors:
    Chmielowiec J, Szlachcic WJ, Yang D, Scavuzzo MA, Wamble K, Sarrion-Perdigones A, Sabek OM, Venken KJT, Borowiak M
    Academic press:
    Nature Communications (rok: 2022, tom: 13(1), strony: 1952), Wydawca: Springer Nature Limited
    Status:
    Published
    DOI:
    10.1038/s41467-022-29646-1 - link to the publication
  4. Endocrine Pancreas Development and Dysfunction Through the Lens of Single-Cell RNA-Sequencing
    Authors:
    Szlachcic WJ, Ziojła N, Kiżewska DK, Kempa M, Borowiak M
    Academic press:
    Frontiers in Cell and Developmental Biology (rok: 2021, tom: 9, strony: 629212), Wydawca: Frontiers Media S.A.
    Status:
    Published
    DOI:
    10.3389/fcell.2021.629212 - link to the publication
  5. Human pancreatic microenvironment promotes β-cell differentiation via non-canonical WNT5A/JNK and BMP signaling
    Authors:
    Chmielowiec J, Szlachcic WJ, Yang D, Scavuzzo MA, Wamble K, Sarrion-Perdigones A, Sabek OM, Venken KJT, Borowiak M
    Academic press:
    Nature Communications (rok: 2022, tom: 13(1), strony: 1952), Wydawca: Springer Nature Limited
    Status:
    Published
    DOI:
    10.1038/s41467-022-29646-1 - link to the publication
  6. Deep into the niche: Deciphering local endoderm-microenvironment interactions in development, homeostasis, and disease of pancreas and intestine
    Authors:
    Szlachcic WJ, Letai KC, Scavuzzo MA, Borowiak M
    Academic press:
    BioEssays (rok: 2023, tom: 45(4), strony: e2200186), Wydawca: Wiley Periodicals LLC
    Status:
    Published
    DOI:
    10.1002/bies.202200186 - link to the publication
  7. Mitogen Synergy: An Emerging Route to Boosting Human Beta Cell Proliferation
    Authors:
    Shcheglova E, Blaszczyk K, Borowiak M.
    Academic press:
    Frontiers in Cell and Developmental Biology (rok: 2021, tom: 9, strony: 45682), Wydawca: Frontiers in Cell and Developmental Biology
    Status:
    Published
    DOI:
    10.3389/fcell.2021.734597 - link to the publication
  8. Mitogen Synergy: An Emerging Route to Boosting Human Beta Cell Proliferation
    Authors:
    Shcheglova E, Blaszczyk K, Borowiak M.
    Academic press:
    Frontiers in Cell and Developmental Biology (rok: 2021, tom: 9, strony: 45682), Wydawca: Frontiers in Cell and Developmental Biology
    Status:
    Published
    DOI:
    10.3389/fcell.2021.734597 - link to the publication
  9. Deep into the niche: Deciphering local endoderm-microenvironment interactions in development, homeostasis, and disease of pancreas and intestine
    Authors:
    Szlachcic WJ, Letai KC, Scavuzzo MA, Borowiak M
    Academic press:
    BioEssays (rok: 2023, tom: 45(4), strony: e2200186), Wydawca: Wiley Periodicals LLC
    Status:
    Published
    DOI:
    10.1002/bies.202200186 - link to the publication
  10. Endocrine Pancreas Development and Dysfunction Through the Lens of Single-Cell RNA-Sequencing
    Authors:
    Szlachcic WJ, Ziojła N, Kiżewska DK, Kempa M, Borowiak M
    Academic press:
    Frontiers in Cell and Developmental Biology (rok: 2021, tom: 9, strony: 629212), Wydawca: Frontiers Media S.A.
    Status:
    Published
    DOI:
    10.3389/fcell.2021.629212 - link to the publication
  11. Mitogen Synergy: An Emerging Route to Boosting Human Beta Cell Proliferation
    Authors:
    Shcheglova E, Blaszczyk K, Borowiak M.
    Academic press:
    Frontiers in Cell and Developmental Biology (rok: 2021, tom: 9, strony: 45682), Wydawca: Frontiers in Cell and Developmental Biology
    Status:
    Published
    DOI:
    10.3389/fcell.2021.734597 - link to the publication

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