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New aspects of negative regulation of RNA polymerase III in yeast Saccharomyces cerevisiae

2019/33/B/NZ1/01012

Keywords

Descriptors

  • NZ1_001: Biologia molekularna
  • NZ3_001: Biologia komórki

Panel

NZ1 – Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution

Instytut Biochemii i Biofizyki PAN

Voivodeship: mazowieckie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr Małgorzata Maria Cieśla

Number of co-investigators in the project: 5

Call

OPUS 17 – announced on 2019-03-15

Amount awarded
1 252 200 PLN
Project start date
2020-09-01
Project end date
2024-08-31
Project duration
48 months (the same as in the proposal)
Project status
Project settled

Project description

Download the project description in a pdf file

Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

Publication in academic press/journals (2)

  1. Functional suppression of a yeast maf1 deletion mutant by overdose of the N-terminal fragment of the largest RNA polymerase III subunit, C160

    Authors:
    Aleksandra Łopusińska, Malak Farhat, Małgorzata Cieśla
    Academic press:
    Gene (year: 2024, volume: 930(2024)148839, pages: 46029), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.gene.2024.148839 – link to the publication

  2. RNA polymerase III transcription machinery and tRNA processing are regulated by the ubiquitin ligase Rsp5

    Authors:
    Aleksandra Łopusińska, Michał Tys, Magdalena Boguta and Małgorzata Cieśla
    Academic press:
    BBA - Molecular Cell Research (year: 2025, volume: Volume 1872, Issue 6, pages: 46033), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bbamcr.2025.119993 – link to the publication

Articles in post-conference publications (12)

  1. Inactivation of Maf1, global negative regulator of tRNA transcription, leads to defects in translation elongation in yeast

    Authors:
    Alicja Armatowska, Małgorzata Cieśla, Michał Świrski, Jan Mikołajczyk, Tomasz W. Turowski, Eliza Molestak, Marek Tchórzewski, Stefan Bresson and Magdalena Boguta
    Conference:
    2nd Polish RNA Biology Meeting (year: 2025, volume: 2nd Polish RNA Biology Meeting, pages: 115), Publisher: Uniwersytet Adama Mickiewicza
    Date:
    conference 24-27 czerwca 2025
    Status:
    Published

  2. Molecular insights into the regulation of RNA polymerase III transcription machinery by the ubiquitin ligase Rsp5

    Authors:
    Aleksandra Łopusińska, Michal Tys, Magdalena Boguta and Małgorzata Cieśla
    Conference:
    OddPols Abstract Book (year: 2023, volume: OddPols 2023, pages: 74), Publisher: OddPols 2023
    Date:
    conference 30 maja-2 czerwca 2023
    Status:
    Published

  3. INACTIVATION OF MAF1, THE GENE ENCODING THE NEGATIVE REGULATOR OF RNA POLYMERASE III, HAS MULTIPLE EFFECTS ON TRANSLATION

    Authors:
    Alicja Armatowska, Jan Słupski, Magdalena Boguta and Małgorzata Cieśla
    Conference:
    Abstract book - 1st Polish Yeast Conference (year: 2022, volume: 1st Polish Yeast Conference, pages: 62), Publisher: Uniwersytet Rzeszowski
    Date:
    conference 22-24 czerwca 2022
    Status:
    Published

  4. TRANSCRIPTION EFFICIENCY OF tRNA GENES DEPENDS ON THE RSP5 LIGASE

    Authors:
    Aleksandra Łopusińska, Magdalena Boguta and Małgorzata Cieśla
    Conference:
    Abstract book - 1st Polish Conference (year: 2022, volume: 1st Polish Yeast Conference, pages: 65), Publisher: Uniwersytet Rzeszowski
    Date:
    conference 22-24 czerwca 2022
    Status:
    Published

  5. Assembly of RNA polymerase III complex in yeast: novel layer of regulation.

    Authors:
    Małgorzata Cieśla, Tomasz Turowski, Marcin Nowotny, David Tollervey and Magdalena Boguta
    Conference:
    ICY15 PROGRAMME & ABSTRACTS (year: 2021, volume: ICY15 meets ICYGMB30, pages: 380), Publisher: International Commission on Yeasts
    Date:
    conference 23-27 sierpnia 2021
    Status:
    Published

  6. RNA POLYMERASE III TRANSCRIPTION, NOVEL LAYERS OF REGULATION

    Authors:
    Małgorzata Cieśla
    Conference:
    Abstract book - 1st Polish Yeast Conference (year: 2022, volume: 1st Polish Yeast Conference, pages: 57), Publisher: Uniwersytet Rzeszowski
    Date:
    conference 22-24 czerwca 2022
    Status:
    Published

  7. The connection between Maf1, a negative regulator of RNA polymerase III, and translation in yeast

    Authors:
    Alicja Armatowska, Jan Słupski, Magdalena Boguta and Małgorzata Cieśla
    Conference:
    OddPols-2021-Conference-Book (year: 2021, volume: OddPols 2021, pages: 101), Publisher: OddPols 2021
    Date:
    conference 14-18 czerwca 2021
    Status:
    Published

  8. The linkage between Maf1-mediated control of tRNA transcription and mRNA translation in yeast Saccharomyces cerevisiae

    Authors:
    Alicja Armatowska, Jan Słupski, Eliza Molestak, Marek Tchórzewski, Stefan Bresson, Małgorzata Cieśla & Magdalena Boguta
    Conference:
    OddPols Abstract Book (year: 2023, volume: OddPols, pages: 79), Publisher: OddPols
    Date:
    conference 30 maja-2 czerwca 2023
    Status:
    Published

  9. Rsp5 ubiquitin ligase is implicated in the control of tRNA processing and RNA polymerase III transcription machinery

    Authors:
    Aleksandra Łopusińska, Michał Tys, Magdalena Boguta, Małgorzata Cieśla
    Conference:
    OddPols-2025 (year: 2025, volume: Odd Pols 2025, pages: 64), Publisher: Stowers Institute
    Date:
    conference 29 maja-1 czerwca 2025
    Status:
    Published

  10. Rsp5 ubiquitin ligase is implicated in the control of tRNA processing and RNA polymerase III transcription machinery

    Authors:
    Aleksandra Łopusińska, Michał Tys, Magdalena Boguta and Małgorzata Cieśla
    Conference:
    2nd Polish RNA Biology Meeting (year: 2025, volume: 2nd Polish RNA Biology Meeting, pages: 181), Publisher: Uniwersytet Adama Mickiewicza
    Date:
    conference 24-27 czerwca 2025
    Status:
    Published

  11. Functional suppression of maf1 deletion mutant of Saccharomyces cerevisiae by overdose of N-terminal domains of the largest Pol III subunit, C160

    Authors:
    Malak Farhat, Aleksandra Łopusińska, Ewa Leśniewska, Małgorzata Cieśla and Magdalena Boguta
    Conference:
    OddPols Abstract Book (year: 2023, volume: OddPols, pages: 73), Publisher: OddPols
    Date:
    conference 30 maja-2 czerwca 2023
    Status:
    Published

  12. Regulation of the RNA polymerase III transcription machinery is dependent on the ubiquitin ligase Rsp5

    Authors:
    Aleksandra Łopusińska, Michał Tys, Magdalena Boguta, Małgorzata Cieśla
    Conference:
    PLRNA2023_Abstract_Book (year: 2023, volume: POLISH RNA BIOLOGY MEETING, pages: 78), Publisher: International Institute of Molecular and Cell Biology
    Date:
    conference 28-30 września 2023
    Status:
    Published

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