Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Molecular mechanisms of biological activity of an antifungal antibiotic amphotericin B

2019/33/B/NZ7/00902

Keywords:

antifungal antibiotics polyene antibiotics molecular imaging hybrid nanoparticles

Descriptors:

  • NZ7_014:
  • NZ1_003:

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Marii Curie-Skłodowskiej w Lublinie, Wydział Matematyki, Fizyki i Informatyki

woj. lubelskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Wiesław Ignacy Gruszecki 

Number of co-investigators in the project: 6

Call: OPUS 17 - announced on 2019-03-15

Amount awarded: 1 843 400 PLN

Project start date (Y-m-d): 2020-02-05

Project end date (Y-m-d): 2024-02-04

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

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Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (4)
  1. How Does the Antibiotic Amphotericin B Enter Membranes and What Does It Do There?
    Authors:
    Sebastian Janik, Rafal Luchowski, Ewa Grela, Wojciech Grudzinski, Wieslaw I. Gruszecki
    Academic press:
    Journal of Physical Chemistry Letters (rok: 2024, tom: 15, strony: 4823–4827), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acs.jpclett.4c00496 - link to the publication
  2. Enhanced Antifungal Activity of Amphotericin B Bound to Albumin: A Trojan Horse" Effect of the Protein
    Authors:
    Ewa Grela Ewa Grela Department of Biophysics, Institute of Physics, Faculty of Mathematics, Physics and Informatics, Maria Curie-Sklodowska University, 20-031 Lublin, Poland More by Ewa Grela Orcidhttps://orcid.org/0000-0002-1667-6780 , Sylwia Stączek, Monika Nowak, Bozena Pawlikowska-Pawlega, Agnieszka Zdybicka-Barabas, Sebastian Janik, Małgorzata Cytryńska, Wojciech Grudzinski, Wieslaw I. Gruszecki, Rafal Luchowski
    Academic press:
    Journal of Physical Chemistry B (rok: 2023, tom: 127, strony: 3632–3640), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acs.jpcb.3c01168 - link to the publication
  3. Enhanced Antifungal Activity of Amphotericin B Bound to Albumin: A Trojan Horse" Effect of the Protein
    Authors:
    Ewa Grela Ewa Grela Department of Biophysics, Institute of Physics, Faculty of Mathematics, Physics and Informatics, Maria Curie-Sklodowska University, 20-031 Lublin, Poland More by Ewa Grela Orcidhttps://orcid.org/0000-0002-1667-6780 , Sylwia Stączek, Monika Nowak, Bozena Pawlikowska-Pawlega, Agnieszka Zdybicka-Barabas, Sebastian Janik, Małgorzata Cytryńska, Wojciech Grudzinski, Wieslaw I. Gruszecki, Rafal Luchowski
    Academic press:
    Journal of Physical Chemistry B (rok: 2023, tom: 127, strony: 3632–3640), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acs.jpcb.3c01168 - link to the publication
  4. Amphotericin B-Silver Hybrid Nanoparticles Help to Unveil the Mechanism of Biological Activity of the Antibiotic: Disintegration of Cell Membranes
    Authors:
    Sebastian Janik, Ewa Grela, SYlwia Stączek, Agnieszka Zdybicka-Barabas, Rafal Luchowski, Wieslaw I. Gruszecki, Wojciech Grudzinski
    Academic press:
    Molecules (rok: 2023, tom: 28, strony: 4687), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules28124687 - link to the publication

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