Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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The effect of cytosolic adaptive responses associated with long-term mitochondrial stress on the Tau protein aggregation.

2019/33/B/NZ3/00533

Keywords:

mitochondria proteostasis neurodegeneration mTOR pathway integrated stress response (ISR) Tau protein

Descriptors:

  • NZ3_001:
  • NZ1_002:
  • NZ3_005:

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Łukasz Samluk 

Number of co-investigators in the project: 3

Call: OPUS 17 - announced on 2019-03-15

Amount awarded: 1 491 100 PLN

Project start date (Y-m-d): 2020-04-23

Project end date (Y-m-d): 2023-10-22

Project duration:: 42 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (2)
  1. Long-term mitochondrial stress induces early steps of Tau aggregation by increasing reactive oxygen species levels and affecting cellular proteostasis.
    Authors:
    Lukasz Samluk*, Piotr Ostapczuk, and Magdalena Dziembowska
    Academic press:
    Molecular Biology of the Cell (MBoC) (rok: 2022, tom: 33, strony: ar67), Wydawca: American Society of Cell Biology
    Status:
    Published
    DOI:
    10.1091/mbc.E21-11-0553 - link to the publication
  2. Immunoproteasome-specific subunit PSMB9 induction is required to regulate cellular proteostasis upon mitochondrial dysfunction.
    Authors:
    Minji Kim, Remigiusz A. Serwa, Lukasz Samluk, Ida Suppanz, Agata Kodroń, Tomasz M. Stępkowski, Praveenraj Elancheliyan, Biniyam Tsegaye, SilkeOeljeklaus, Michal Wasilewski, Bettina Warscheid, and Agnieszka Chacinska
    Academic press:
    Nature communications (rok: 2023, tom: 14, strony: Article number: 4092), Wydawca: Nature Portfolio
    Status:
    Published
    DOI:
    10.1038/s41467-023-39642-8 - link to the publication

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