Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Linking abnormal Ca2+ signaling and the unfolded protein response with Huntington's disease pathology in both YAC128 mouse model and iPSC-derived neurons from HD patients

2019/33/B/NZ3/02889

Keywords:

Huntington's disease neurons iPSC HAP1A transgenic mice calcium signaling UPR neurodegenertion

Descriptors:

  • NZ3_5: Molecular neurobiology
  • NZ3_6: Cell neurobiology
  • NZ3_7: Signal transduction

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Międzynarodowy Instytut Biologii Molekularnej i Komórkowej w Warszawie

woj.

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Magdalena Czeredys 

Number of co-investigators in the project: 4

Call: OPUS 17 - announced on 2019-03-15

Amount awarded: 1 857 550 PLN

Project start date (Y-m-d): 2020-04-01

Project end date (Y-m-d): 2024-09-30

Project duration:: 54 months (the same as in the proposal)

Project status: Project completed

Project description

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Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (11)
  1. Generation of three human iPSC lines from patients with Huntington's disease with different CAG lengths and human control iPSC line from a healthy donor
    Authors:
    Latoszek E, Piechota M, Liszewska E, Hansíková H, Klempíř J, Mühlbäck A, Landwehrmeyer GB, Kuznicki J, Czeredys M.
    Academic press:
    Stem Cell Research (rok: 2022, tom: 64, strony: 45662), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.scr.2022.102931 - link to the publication
  2. Dysregulation of Neuronal Calcium Signaling via Store-Operated Channels in Huntington's Disease
    Authors:
    Magdalena Czeredys
    Academic press:
    Front. Cell Dev. Biol. (rok: 2020, tom: 8:611735, strony: ), Wydawca: Frontiers Media S.A.
    Status:
    Published
    DOI:
    10.3389/fcell.2020.611735 - link to the publication
  3. Siah-1-interacting protein regulates mutated huntingtin protein aggregation in Huntington's disease models
    Authors:
    Latoszek E, Wiweger M, Ludwiczak J, Dunin-Horkawicz S, Kuznicki J, Czeredys M.
    Academic press:
    Cell & Bioscience (rok: 2022, tom: 0,523611111111111, strony: 45678), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1186/s13578-022-00755-0 - link to the publication
  4. Molecular Components of Store-Operated Calcium Channels in the Regulation of Neural Stem Cell Physiology, Neurogenesis, and the Pathology of Huntington's Disease
    Authors:
    Ewelina Latoszek, Magdalena Czeredys
    Academic press:
    Front. Cell Dev. Biol. (rok: 2021, tom: 9:657337, strony: ), Wydawca: Frontiers Media S.A.
    Status:
    Published
    DOI:
    10.3389/fcell.2021.657337 - link to the publication
  5. Dysregulation of Neuronal Calcium Signaling via Store-Operated Channels in Huntington's Disease
    Authors:
    Magdalena Czeredys
    Academic press:
    Front. Cell Dev. Biol. (rok: 2020, tom: 8:611735, strony: ), Wydawca: Frontiers Media S.A.
    Status:
    Published
    DOI:
    10.3389/fcell.2020.611735 - link to the publication
  6. Siah-1-interacting protein regulates mutated huntingtin protein aggregation in Huntington's disease models
    Authors:
    Latoszek E, Wiweger M, Ludwiczak J, Dunin-Horkawicz S, Kuznicki J, Czeredys M.
    Academic press:
    Cell & Bioscience (rok: 2022, tom: 0,523611111111111, strony: 45678), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1186/s13578-022-00755-0 - link to the publication
  7. Generation of three human iPSC lines from patients with Huntington's disease with different CAG lengths and human control iPSC line from a healthy donor
    Authors:
    Latoszek E, Piechota M, Liszewska E, Hansíková H, Klempíř J, Mühlbäck A, Landwehrmeyer GB, Kuznicki J, Czeredys M.
    Academic press:
    Stem Cell Research (rok: 2022, tom: 64, strony: 45662), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.scr.2022.102931 - link to the publication
  8. Generation of two human iPSC lines from dermal fibroblasts of adult- and juvenile-onset Huntington's disease patients and two healthy donors.
    Authors:
    Piechota M, Latoszek E, Liszewska E, Hansíková H, Klempíř J, Mühlbäck A, Landwehrmeyer GB, Kuźnicki J, Czeredys M.
    Academic press:
    Stem Cell Research (rok: 2023, tom: 71, strony: 45662), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.scr.2023.103194 - link to the publication
  9. Molecular Components of Store-Operated Calcium Channels in the Regulation of Neural Stem Cell Physiology, Neurogenesis, and the Pathology of Huntington's Disease
    Authors:
    Ewelina Latoszek, Magdalena Czeredys
    Academic press:
    Front. Cell Dev. Biol. (rok: 2021, tom: 9:657337, strony: ), Wydawca: Frontiers Media S.A.
    Status:
    Published
    DOI:
    10.3389/fcell.2021.657337 - link to the publication
  10. Molecular Components of Store-Operated Calcium Channels in the Regulation of Neural Stem Cell Physiology, Neurogenesis, and the Pathology of Huntington's Disease
    Authors:
    Ewelina Latoszek, Magdalena Czeredys
    Academic press:
    Front. Cell Dev. Biol. (rok: 2021, tom: 9:657337, strony: ), Wydawca: Frontiers Media S.A.
    Status:
    Published
    DOI:
    10.3389/fcell.2021.657337 - link to the publication
  11. Dysregulation of Neuronal Calcium Signaling via Store-Operated Channels in Huntington's Disease
    Authors:
    Magdalena Czeredys
    Academic press:
    Front. Cell Dev. Biol. (rok: 2020, tom: 8:611735, strony: ), Wydawca: Frontiers Media S.A.
    Status:
    Published
    DOI:
    10.3389/fcell.2020.611735 - link to the publication

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