Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Deciphering the molecular causes and consequences of circular RNAs elevated expression levels in myotonic dystrophy type 1(DM1)

2019/33/B/NZ5/02473

Keywords:

circular RNAs myotonic dystrophy type 1 (DM1) human neuromuscular disorders pre-mRNA splicing MBNL proteins

Descriptors:

  • NZ5_3: Pathogenesis of human diseases

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Instytut Chemii Bioorganicznej Polskiej Akademii Nauk

woj.

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Marzena Wojciechowska 

Number of co-investigators in the project: 3

Call: OPUS 17 - announced on 2019-03-15

Amount awarded: 1 089 500 PLN

Project start date (Y-m-d): 2020-11-27

Project end date (Y-m-d): 2025-11-26

Project duration:: 60 months (the same as in the proposal)

Project status: Pending project

Project description

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Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (6)
  1. Differential fates of introns in gene expression due to global alternative splicing
    Authors:
    Anjani Kumari, Saam Sedehizadeh, John David Brook, Piotr Kozlowski & Marzena Wojciechowska
    Academic press:
    Human Genetics (rok: 2021, tom: 141, strony: 31-47), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00439-021-02409-6 - link to the publication
  2. Splicing in two skeletal muscle transcripts correlates with clinical phenotype in myotonic dystrophy type 1 patients
    Authors:
    Saam Sedehizadeh, Marzena Wojciechowska, Ami Ketley, J David Brook, Paul Maddison
    Academic press:
    Journal of Neurology (rok: 2022, tom: 269 (2022), strony: 2784–2787), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00415-021-10917-8 - link to the publication
  3. Differential fates of introns in gene expression due to global alternative splicing
    Authors:
    Anjani Kumari, Saam Sedehizadeh, John David Brook, Piotr Kozlowski & Marzena Wojciechowska
    Academic press:
    Human Genetics (rok: 2021, tom: 141, strony: 31-47), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00439-021-02409-6 - link to the publication
  4. Splicing in two skeletal muscle transcripts correlates with clinical phenotype in myotonic dystrophy type 1 patients
    Authors:
    Saam Sedehizadeh, Marzena Wojciechowska, Ami Ketley, J David Brook, Paul Maddison
    Academic press:
    Journal of Neurology (rok: 2022, tom: 269 (2022), strony: 2784–2787), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00415-021-10917-8 - link to the publication
  5. Differential fates of introns in gene expression due to global alternative splicing
    Authors:
    Anjani Kumari, Saam Sedehizadeh, John David Brook, Piotr Kozlowski & Marzena Wojciechowska
    Academic press:
    Human Genetics (rok: 2021, tom: 141, strony: 31-47), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00439-021-02409-6 - link to the publication
  6. Splicing in two skeletal muscle transcripts correlates with clinical phenotype in myotonic dystrophy type 1 patients
    Authors:
    Saam Sedehizadeh, Marzena Wojciechowska, Ami Ketley, J David Brook, Paul Maddison
    Academic press:
    Journal of Neurology (rok: 2022, tom: 269 (2022), strony: 2784–2787), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00415-021-10917-8 - link to the publication

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