Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Określenie roli szlaku TGFbeta1/Smad w procesie fenotypowego przejścia fibroblastów oskrzelowych w miofibroblasty w astmie

2019/32/T/NZ3/00405

Keywords:

Descriptors:

  • NZ3_1: Cell biology
  • NZ1_1: Molecular biology
  • NZ5_7: Human disease treatment

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Dawid Wnuk 

Number of co-investigators in the project: 2

Call: ETIUDA 7 - announced on 2018-12-14

Amount awarded: 95 844 PLN

Project start date (Y-m-d): 2019-10-01

Project end date (Y-m-d): 2020-09-30

Project duration:: 12 months (the same as in the proposal)

Project status: Project settled

Project description

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Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (6)
  • Articles in post-conference publications (1)
  1. Responsiveness of human bronchial fibroblasts and epithelial cells from asthmatic and non-asthmatic donors to the transforming growth factor-β1 in epithelial-mesenchymal trophic unit model
    Authors:
    Milena Paw, Dawid Wnuk, Bogdan Jakieła, Grażyna Bochenek, Krzysztof Sładek, Zbigniew Madeja, Marta Michalik
    Academic press:
    BMC Molecular and Cell Biology (rok: 2021, tom: 22; 1, strony: 45305), Wydawca: BMCCAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
    Status:
    Published
    DOI:
    10.1186/s12860-021-00356-8 - link to the publication
  2. When healing turns into killing - the pathophysiology of pancreatic and hepatic fibrosis
    Authors:
    Pawel E Ferdek, Daria Krzysztofik, Kinga B Stopa, Agnieszka A Kusiak, Milena Paw, Dawid Wnuk, Monika A Jakubowska
    Academic press:
    The Journal of Physiology (rok: 2022, tom: 600; 11, strony: 2579–2612), Wydawca: WILEY, 111 RIVER ST, HOBOKEN 07030-5774, NJ
    Status:
    Published
    DOI:
    10.1113/JP281135 - link to the publication
  3. Fibroblast to myofibroblast transition is enhanced in asthma-derived fibroblasts in comparison to fibroblasts derived from non-asthmatic patients in 3D in vitro cultures due to Smad2/3 signalling
    Authors:
    Dawid Wnuk, Sławomir Lasota, Milena Paw, Zbigniew Madeja, Marta Michalik
    Academic press:
    Acta Biochimica Polonica (rok: 2020, tom: 67; 4, strony: 441-448), Wydawca: ACTA BIOCHIMICA POLONICA PASTEURA 3, 02-093 WARSAW, POLAND
    Status:
    Published
    DOI:
    10.18388/abp.2020_5412 - link to the publication
  4. SB203580-A Potent p38 MAPK Inhibitor Reduces the Profibrotic Bronchial Fibroblasts Transition Associated with Asthma
    Authors:
    Milena Paw, Dawid Wnuk, Kinga Nit, Sylwia Bobis-Wozowicz, Rafał Szychowski, Alicja Ślusarczyk, Zbigniew Madeja, Marta Michalik
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22; 23, strony: 45307), Wydawca: MDPIST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
    Status:
    Published
    DOI:
    10.3390/ijms222312790 - link to the publication
  5. Enhanced asthma‑related fibroblast to myofibroblast transition is the result of profibrotic TGF-β/Smad2/3 pathway intensification and antifibrotic TGF‑β/Smad1/5/(8)9 pathway impairment
    Authors:
    Dawid Wnuk, Milena Paw, Karolina Ryczek, Grażyna Bochenek, Krzysztof Sładek, Zbigniew Madeja, Marta Michalik
    Academic press:
    Scientific Reports (rok: 2020, tom: 10; 1, strony: 45307), Wydawca: NATURE RESEARCHHEIDELBERGER PLATZ 3, BERLIN 14197, GERMANY
    Status:
    Published
    DOI:
    10.1038/s41598-020-73473-7 - link to the publication
  6. Discrimination between NSIP- and IPF-Derived Fibroblasts Based on Multi-Parameter Characterization of Their Growth, Morphology and Physic-Chemical Properties
    Authors:
    Barbara Orzechowska, Kamil Awsiuk, Dawid Wnuk, Joanna Pabijan, Tomasz Stachura, Jerzy Soja, Krzysztof Sładek, Joanna Raczkowska
    Academic press:
    International Journal of Molecular Sciences (rok: 2022, tom: 23; 4, strony: 45314), Wydawca: MDPIST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
    Status:
    Published
    DOI:
    10.3390/ijms23042162 - link to the publication
  1. Chalcones: isoliquiritigenin and flavokawain A reduce asthma-related fibroblast to myofibroblast transition, intensified by TGF-ß1
    Authors:
    Dawid Wnuk, Alicja Ślusarczyk, Milena Paw, Justyna Drukała, Marta Michalik
    Conference:
    ERS International Congress 2021 (rok: 2021, ), Wydawca: EUROPEAN RESPIRATORY SOC JOURNALS LTD442 GLOSSOP RD, SHEFFIELD S10 2PX, ENGLAND
    Data:
    konferencja 5-8.09.2021
    Status:
    Published

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